SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5huo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5huo NICOTINATE-NUCLEOTID
E DIPHOSPHORYLASE
(CARBOXYLATING)
(Streptococcus
pyogenes) 		4 / 4 THR A  85
LEU A  84
LEU A  57
GLN A  61
 None
 1.21A 1fbmA-5huoA:
undetectable		 1fbmA-5huoA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5huo NICOTINATE-NUCLEOTID
E DIPHOSPHORYLASE
(CARBOXYLATING)
(Streptococcus
pyogenes) 		4 / 6 ARG A 256
ILE A 262
PHE A 257
GLU A 244
 None
 1.45A 1nsiC-5huoA:
undetectable
1nsiD-5huoA:
undetectable		 1nsiC-5huoA:
21.38
1nsiD-5huoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 5huo NICOTINATE-NUCLEOTID
E DIPHOSPHORYLASE
(CARBOXYLATING)
(Streptococcus
pyogenes) 		6 / 11 ILE A 176
ALA A 208
GLU A 210
ILE A 220
VAL A 201
VAL A 217
 None
 1.12A 3kw4A-5huoA:
undetectable		 3kw4A-5huoA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 5huo NICOTINATE-NUCLEOTID
E DIPHOSPHORYLASE
(CARBOXYLATING)
(Streptococcus
pyogenes) 		3 / 3 ALA A 178
VAL A 179
GLN A 188
 None
 0.73A 3of4B-5huoA:
undetectable		 3of4B-5huoA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 5huo NICOTINATE-NUCLEOTID
E DIPHOSPHORYLASE
(CARBOXYLATING)
(Streptococcus
pyogenes) 		5 / 11 LEU A 227
LEU A 260
THR A 253
LEU A 128
ILE A 249
 None
 1.11A 3tqbA-5huoA:
undetectable		 3tqbA-5huoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5huo NICOTINATE-NUCLEOTID
E DIPHOSPHORYLASE
(CARBOXYLATING)
(Streptococcus
pyogenes) 		5 / 9 ALA A 233
ILE A 243
ALA A 212
ALA A 213
ILE A 220
 None
 1.08A 4lbgB-5huoA:
undetectable		 4lbgB-5huoA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 5huo NICOTINATE-NUCLEOTID
E DIPHOSPHORYLASE
(CARBOXYLATING)
(Streptococcus
pyogenes) 		5 / 12 ASP A  82
ALA A 152
TYR A 151
ASP A   7
THR A  58
 None
 1.25A 4mm4A-5huoA:
undetectable		 4mm4A-5huoA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 5huo NICOTINATE-NUCLEOTID
E DIPHOSPHORYLASE
(CARBOXYLATING)
(Streptococcus
pyogenes) 		5 / 12 ASP A  82
ALA A 152
TYR A 151
ASP A   7
THR A  58
 None
 1.18A 4mm8A-5huoA:
undetectable		 4mm8A-5huoA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5huo NICOTINATE-NUCLEOTID
E DIPHOSPHORYLASE
(CARBOXYLATING)
(Streptococcus
pyogenes) 		4 / 7 PHE A 257
GLU A 244
ARG A 256
ILE A 262
 None
 1.42A 4nosA-5huoA:
undetectable
4nosB-5huoA:
undetectable		 4nosA-5huoA:
21.73
4nosB-5huoA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5huo NICOTINATE-NUCLEOTID
E DIPHOSPHORYLASE
(CARBOXYLATING)
(Streptococcus
pyogenes) 		4 / 6 PHE A 257
GLU A 244
ARG A 256
ILE A 262
 None
 1.42A 4nosC-5huoA:
undetectable
4nosD-5huoA:
undetectable		 4nosC-5huoA:
21.73
4nosD-5huoA:
21.73