SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5huq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 7 THR A 283
GLY A 286
ASP A   9
TYR A   8
 None
 1.02A 1bu5A-5huqA:
3.0		 1bu5A-5huqA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 8 ARG A 350
GLU A 203
GLN A 357
SER A 219
 SO4  A 509 (-4.5A)
SO4  A 509 (-4.7A)
None
None
 1.32A 1nx9A-5huqA:
undetectable		 1nx9A-5huqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 8 ARG A 350
GLU A 203
GLN A 357
SER A 219
 SO4  A 509 (-4.5A)
SO4  A 509 (-4.7A)
None
None
 1.30A 1nx9B-5huqA:
undetectable		 1nx9B-5huqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 8 ARG A 350
GLU A 203
GLN A 357
SER A 219
 SO4  A 509 (-4.5A)
SO4  A 509 (-4.7A)
None
None
 1.33A 1nx9C-5huqA:
undetectable		 1nx9C-5huqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 8 ARG A 350
GLU A 203
GLN A 357
SER A 219
 SO4  A 509 (-4.5A)
SO4  A 509 (-4.7A)
None
None
 1.32A 1nx9D-5huqA:
undetectable		 1nx9D-5huqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 10 ILE A 205
ALA A 345
ILE A 366
ARG A 211
ILE A 362
 None
 1.12A 1rb3A-5huqA:
undetectable		 1rb3A-5huqA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 8 ASP A 290
PHE A 374
ARG A 320
ALA A 296
 None
None
SO4  A 506 ( 3.4A)
None
 1.05A 1rqpC-5huqA:
undetectable		 1rqpC-5huqA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 8 ASP A 290
PHE A 374
ARG A 320
ALA A 296
 None
None
SO4  A 506 ( 3.4A)
None
 1.02A 1rqpA-5huqA:
undetectable		 1rqpA-5huqA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 7 ALA A 360
ASP A 356
GLY A 202
ILE A 346
 None
 0.81A 1t7jB-5huqA:
undetectable		 1t7jB-5huqA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 12 LEU A 147
ALA A 231
ILE A 144
ILE A 155
ALA A 191
 None
 0.96A 2bxcA-5huqA:
undetectable		 2bxcA-5huqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 11 GLY A 181
SER A  71
ILE A 190
ALA A 159
ILE A 166
 4EY  A 501 (-3.7A)
4EY  A 501 (-3.6A)
None
None
None
 1.10A 2nnhA-5huqA:
undetectable		 2nnhA-5huqA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 11 ALA A 231
ALA A 159
HIS A 133
GLY A 189
ILE A 144
 None
None
None
4EY  A 501 (-3.5A)
None
 1.04A 2x1lA-5huqA:
2.2		 2x1lA-5huqA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 12 ALA A 231
ALA A 159
HIS A 133
GLY A 189
ILE A 144
 None
None
None
4EY  A 501 (-3.5A)
None
 1.07A 2x1lB-5huqA:
3.1		 2x1lB-5huqA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 11 ALA A 231
ALA A 159
HIS A 133
GLY A 189
ILE A 144
 None
None
None
4EY  A 501 (-3.5A)
None
 1.08A 2x1lC-5huqA:
3.1		 2x1lC-5huqA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 7 MET A 399
VAL A 412
ILE A 281
TYR A 403
 None
 1.15A 2yfbA-5huqA:
undetectable		 2yfbA-5huqA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 7 ILE A 293
PHE A 374
MET A 300
THR A 301
 None
 1.09A 2zxwN-5huqA:
undetectable
2zxwW-5huqA:
undetectable		 2zxwN-5huqA:
20.72
2zxwW-5huqA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 7 ILE A 293
PHE A 374
MET A 300
THR A 301
 None
 1.05A 3ag4N-5huqA:
undetectable
3ag4W-5huqA:
undetectable		 3ag4N-5huqA:
20.72
3ag4W-5huqA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 12 ALA A 274
GLY A  24
VAL A 316
ILE A 314
THR A 283
 None
 1.03A 3c6gA-5huqA:
undetectable		 3c6gA-5huqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 9 LEU A  86
SER A  70
ILE A 166
ILE A  51
GLY A 262
 None
 1.02A 3cv9A-5huqA:
undetectable		 3cv9A-5huqA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 11 ALA A 360
ASP A 356
ILE A 354
GLY A 202
ILE A 346
 None
 1.05A 3ebzA-5huqA:
undetectable		 3ebzA-5huqA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 12 GLY A 189
ALA A 104
ASP A  72
GLY A 169
VAL A  67
 4EY  A 501 (-3.5A)
4EY  A 501 (-4.1A)
4EY  A 501 (-3.3A)
None
None
 1.15A 3n3iA-5huqA:
undetectable		 3n3iA-5huqA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 9 ALA A 360
ASP A 356
ILE A 354
GLY A 202
ILE A 346
 None
 1.09A 3nu4A-5huqA:
undetectable		 3nu4A-5huqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		3 / 3 HIS A 221
ARG A 183
GLU A 256
 None
 0.70A 3qf1A-5huqA:
undetectable		 3qf1A-5huqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 12 ILE A 205
ALA A 345
ILE A 366
ARG A 211
ILE A 362
 None
 1.11A 3ql3A-5huqA:
undetectable		 3ql3A-5huqA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 11 ALA A 360
ASP A 356
ILE A 354
GLY A 202
ILE A 346
 None
 1.06A 3s53B-5huqA:
undetectable		 3s53B-5huqA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 4 LEU A 419
GLY A 420
GLY A 418
THR A 283
 None
 0.94A 3si7A-5huqA:
undetectable		 3si7A-5huqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 4 SER A 282
ASP A 290
ASP A 321
ALA A 296
 None
None
SO4  A 505 ( 4.7A)
None
 1.43A 3uj6A-5huqA:
2.1		 3uj6A-5huqA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 12 HIS A 174
SER A 180
ASP A 417
LEU A 419
GLY A 420
 4EY  A 501 ( 4.5A)
4EY  A 501 (-4.7A)
None
None
None
 1.18A 4foxB-5huqA:
undetectable		 4foxB-5huqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 6 LEU A 147
ILE A 155
THR A 230
GLY A 145
 None
 0.99A 4l39A-5huqA:
undetectable		 4l39A-5huqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 7 LEU A 147
ILE A 155
THR A 230
GLY A 145
 None
 0.96A 4l39B-5huqA:
undetectable		 4l39B-5huqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 12 ILE A 205
ALA A 345
ILE A 366
ARG A 211
ILE A 362
 None
 1.10A 4ptjA-5huqA:
undetectable		 4ptjA-5huqA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		3 / 3 VAL A 240
LEU A 233
MET A 255
 None
 0.65A 5ikrA-5huqA:
undetectable		 5ikrA-5huqA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 5 HIS A 133
ILE A 190
SER A 140
ALA A 159
 None
None
SO4  A 512 ( 4.5A)
None
 1.11A 5msdA-5huqA:
undetectable		 5msdA-5huqA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 4 ASN A 307
SER A 282
ALA A 280
VAL A 412
 None
 1.27A 5nm5A-5huqA:
undetectable		 5nm5A-5huqA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		4 / 7 GLY A 418
GLY A 420
ASN A 307
THR A 306
 None
 0.74A 5ybbB-5huqA:
undetectable		 5ybbB-5huqA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 11 SER A 250
GLY A 249
ILE A 247
ILE A  82
ILE A 237
 None
 0.93A 6gp2A-5huqA:
undetectable		 6gp2A-5huqA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA
(Lactobacillus
plantarum) 		5 / 11 SER A 250
GLY A 249
ILE A 247
ILE A  82
ILE A 237
 None
 0.93A 6gp2B-5huqA:
undetectable		 6gp2B-5huqA:
10.24