SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hus'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.17A 1ddrB-5husA:
undetectable		 1ddrB-5husA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.15A 1ddsA-5husA:
2.3		 1ddsA-5husA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.08A 1ddsB-5husA:
undetectable		 1ddsB-5husA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.05A 1dhfA-5husA:
3.1		 1dhfA-5husA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.07A 1dhfB-5husA:
2.8		 1dhfB-5husA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.18A 1jolA-5husA:
2.6		 1jolA-5husA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		3 / 3 ALA A 244
VAL A 246
TRP A  14
 None
 0.83A 1nt5A-5husA:
undetectable		 1nt5A-5husA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		3 / 3 ALA A 244
VAL A 246
TRP A  14
 None
 0.83A 1nt5B-5husA:
undetectable		 1nt5B-5husA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ALA A 107
TYR A  72
VAL A 208
GLY A 106
ILE A 105
 None
 1.34A 2dcfA-5husA:
undetectable		 2dcfA-5husA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 10 GLY A  55
LEU A  59
LEU A  56
LEU A 300
ILE A 297
 None
 1.09A 2f8dA-5husA:
undetectable		 2f8dA-5husA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 10 GLY A  55
LEU A  59
LEU A  56
LEU A 300
ILE A 297
 None
 1.11A 2f8dB-5husA:
undetectable		 2f8dB-5husA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.03A 2w3bA-5husA:
2.7		 2w3bA-5husA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.06A 2w3bB-5husA:
3.0		 2w3bB-5husA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.12A 2w3mA-5husA:
undetectable		 2w3mA-5husA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		6 / 11 SER A  66
LEU A 247
LEU A  25
SER A  61
LEU A  60
LEU A 300
 None
 1.44A 2xn5A-5husA:
undetectable		 2xn5A-5husA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		4 / 6 LEU A  94
ILE A  92
MET A  85
VAL A 189
 None
 1.19A 2ygoA-5husA:
undetectable		 2ygoA-5husA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 11 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.34A 2zzaB-5husA:
2.4		 2zzaB-5husA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		4 / 8 GLU A 180
ASN A 182
HIS A 181
ILE A 175
 None
 1.16A 3kp6A-5husA:
3.7
3kp6B-5husA:
3.5		 3kp6A-5husA:
21.05
3kp6B-5husA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		4 / 7 SER A  54
LEU A  77
ILE A  92
PHE A  86
 None
 1.05A 3ln1C-5husA:
undetectable		 3ln1C-5husA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 11 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.07A 3n0hA-5husA:
2.9		 3n0hA-5husA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.18A 3ql0A-5husA:
2.6		 3ql0A-5husA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.07A 3s3vA-5husA:
2.9		 3s3vA-5husA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		4 / 8 ALA A 204
SER A 201
LEU A  74
TYR A 248
 None
 1.14A 4ijiF-5husA:
undetectable		 4ijiF-5husA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.10A 4kebB-5husA:
2.8		 4kebB-5husA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.08A 4kfjB-5husA:
undetectable		 4kfjB-5husA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.05A 4m6kA-5husA:
3.1		 4m6kA-5husA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 11 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.18A 4qi9C-5husA:
undetectable		 4qi9C-5husA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 11 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.17A 4qleB-5husA:
undetectable		 4qleB-5husA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 11 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.16A 4qlfA-5husA:
undetectable		 4qlfA-5husA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.17A 4qlgA-5husA:
undetectable		 4qlgA-5husA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.18A 4rgcA-5husA:
2.6		 4rgcA-5husA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.15A 5e8qB-5husA:
2.4		 5e8qB-5husA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		4 / 6 ALA A 186
THR A 187
VAL A 193
HIS A 185
 None
 0.92A 5eckA-5husA:
undetectable		 5eckA-5husA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		4 / 6 ALA A 186
THR A 187
VAL A 193
HIS A 185
 None
 0.91A 5eckD-5husA:
2.2		 5eckD-5husA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		4 / 6 ALA A 186
THR A 187
VAL A 193
HIS A 185
 None
 0.94A 5ecoA-5husA:
undetectable		 5ecoA-5husA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.14A 5hi6A-5husA:
2.3		 5hi6A-5husA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		5 / 12 ILE A 200
ALA A 147
ILE A 111
LEU A 207
THR A 148
 None
 1.17A 5hi6B-5husA:
undetectable		 5hi6B-5husA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN
(Candida
albicans) 		4 / 8 ASP A  83
ARG A  79
GLU A  97
ASP A 146
 None
 1.25A 6mn4B-5husA:
undetectable		 6mn4B-5husA:
20.42