SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 11 ALA A 120
SER A 118
ALA A 131
LEU A 157
SER A 156
 None
 1.22A 1tz8A-5hv6A:
undetectable
1tz8B-5hv6A:
undetectable		 1tz8A-5hv6A:
18.55
1tz8B-5hv6A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 11 ALA A 131
LEU A 157
SER A 156
ALA A 120
SER A 118
 None
 1.21A 1tz8A-5hv6A:
undetectable
1tz8B-5hv6A:
undetectable		 1tz8A-5hv6A:
18.55
1tz8B-5hv6A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 ILE A  92
ALA A  47
MET A 100
LEU A 146
ILE A 182
 None
 1.17A 1xzxX-5hv6A:
undetectable		 1xzxX-5hv6A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 PHE A   8
ILE A  92
LEU A 146
THR A 103
 None
 0.96A 3nxuA-5hv6A:
undetectable		 3nxuA-5hv6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 LEU A 215
GLY A 255
GLY A 254
ILE A 141
 None
 0.57A 4yjiA-5hv6A:
undetectable		 4yjiA-5hv6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 LEU A 138
ILE A 141
GLY A 142
ASP A 144
ALA A 115
 None
 1.08A 5h5fA-5hv6A:
undetectable		 5h5fA-5hv6A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 SER A 250
GLY A 216
GLY A 214
SER A 212
VAL A 220
 None
 1.17A 5kpcB-5hv6A:
undetectable		 5kpcB-5hv6A:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 ILE A 296
LEU A 279
LEU A  26
ALA A 301
GLY A 303
 None
 1.09A 5uxdB-5hv6A:
1.2		 5uxdB-5hv6A:
18.91