SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hvc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 5hvc TYPE I MODULAR
POLYKETIDE SYNTHASE
(Mycobacterium
ulcerans) 		5 / 12 LEU A2132
LEU A2128
PHE A2089
THR A2071
ALA A2099
 None
 1.21A 1n5xA-5hvcA:
undetectable		 1n5xA-5hvcA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 5hvc TYPE I MODULAR
POLYKETIDE SYNTHASE
(Mycobacterium
ulcerans) 		5 / 12 LEU A2132
LEU A2128
PHE A2089
THR A2071
ALA A2099
 None
 1.21A 1n5xB-5hvcA:
undetectable		 1n5xB-5hvcA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 5hvc TYPE I MODULAR
POLYKETIDE SYNTHASE
(Mycobacterium
ulcerans) 		4 / 6 ALA A2064
ALA A2068
THR A2071
PHE A2089
 None
 1.01A 2xfhA-5hvcA:
undetectable		 2xfhA-5hvcA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 5hvc TYPE I MODULAR
POLYKETIDE SYNTHASE
(Mycobacterium
ulcerans) 		5 / 9 ILE A2083
VAL A2067
ALA A2070
THR A2105
ALA A2099
 None
 1.31A 4oqrA-5hvcA:
undetectable		 4oqrA-5hvcA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5hvc TYPE I MODULAR
POLYKETIDE SYNTHASE
(Mycobacterium
ulcerans) 		4 / 6 ILE A2094
ALA A2070
THR A2071
VAL A2074
 None
 0.72A 5eclD-5hvcA:
undetectable		 5eclD-5hvcA:
10.45