SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hvf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5hvf CARBOXYPEPTIDASE B2
VHH-I83
(Homo
sapiens;
Vicugna
pacos) 		3 / 3 ARG B  70
ASP B 100
ASN A 328
 None
 0.91A 1nbhA-5hvfB:
undetectable		 1nbhA-5hvfB:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5hvf CARBOXYPEPTIDASE B2
VHH-I83
(Homo
sapiens;
Vicugna
pacos) 		3 / 3 ARG B  70
ASP B 100
ASN A 328
 None
 0.88A 1nbhD-5hvfB:
undetectable		 1nbhD-5hvfB:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		3 / 3 ASP A 348
HIS A 288
ASP A 155
 FLC  A 509 ( 4.8A)
ZN  A 508 (-3.1A)
None
 0.67A 1nw5A-5hvfA:
undetectable		 1nw5A-5hvfA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 7 SER A 291
SER A 289
PHE A 372
GLU A 363
 None
None
None
FLC  A 509 (-3.3A)
 1.22A 2c8aA-5hvfA:
undetectable		 2c8aA-5hvfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		5 / 7 GLY A 371
SER A 291
SER A 289
PHE A 372
GLU A 363
 None
None
None
None
FLC  A 509 (-3.3A)
 1.27A 2c8aB-5hvfA:
undetectable		 2c8aB-5hvfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 6 SER A 291
SER A 289
PHE A 372
GLU A 363
 None
None
None
FLC  A 509 (-3.3A)
 1.28A 2c8aC-5hvfA:
undetectable		 2c8aC-5hvfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 5 SER A 289
LEU A 373
GLY A 371
ARG A 214
 None
 0.91A 2j2pA-5hvfA:
undetectable
2j2pB-5hvfA:
undetectable		 2j2pA-5hvfA:
19.80
2j2pB-5hvfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 6 ARG A 214
SER A 289
LEU A 373
GLY A 371
 None
 1.01A 2j2pA-5hvfA:
undetectable
2j2pC-5hvfA:
undetectable		 2j2pA-5hvfA:
19.80
2j2pC-5hvfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 6 ARG A 214
SER A 289
LEU A 373
GLY A 371
 None
 0.99A 2j2pD-5hvfA:
undetectable
2j2pF-5hvfA:
undetectable		 2j2pD-5hvfA:
19.80
2j2pF-5hvfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		5 / 12 LEU A 373
ILE A  80
LEU A  79
ASP A  75
MET A 215
 None
 1.15A 2qo6A-5hvfA:
undetectable		 2qo6A-5hvfA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 6 GLU A 385
MET A 287
PHE A 168
ILE A 164
 None
 1.20A 2w98B-5hvfA:
undetectable		 2w98B-5hvfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		5 / 12 PHE A 195
PHE A 168
ALA A 151
ALA A 386
ALA A 388
 None
 1.24A 2x2nA-5hvfA:
undetectable		 2x2nA-5hvfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		5 / 10 GLY A 346
PHE A 237
HIS A 159
THR A 361
ILE A 158
 None
None
ZN  A 508 ( 3.2A)
FLC  A 509 ( 4.6A)
None
 1.12A 2y7wB-5hvfA:
undetectable		 2y7wB-5hvfA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 8 HIS A 118
ILE A 173
TRP A 110
PHE A 113
 None
 1.30A 3ccfB-5hvfA:
undetectable		 3ccfB-5hvfA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 5 ARG A 235
ARG A 302
GLY A 336
GLU A 338
 FLC  A 509 (-2.8A)
None
None
None
 1.17A 3k9fA-5hvfA:
3.5
3k9fB-5hvfA:
3.5
3k9fC-5hvfA:
3.1		 3k9fA-5hvfA:
21.43
3k9fB-5hvfA:
21.43
3k9fC-5hvfA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5hvf VHH-I83
(Vicugna
pacos) 		5 / 12 VAL B   2
ALA B  24
ARG B  70
VAL B  77
ALA B  96
 None
 0.88A 3qxtA-5hvfB:
18.7		 3qxtA-5hvfB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5hvf VHH-I83
(Vicugna
pacos) 		5 / 12 VAL B   2
ALA B  24
MET B  34
VAL B  77
ALA B  96
 None
 1.03A 3qxtA-5hvfB:
18.7		 3qxtA-5hvfB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5hvf VHH-I83
(Vicugna
pacos) 		7 / 12 VAL B   2
LEU B   4
ALA B  24
ARG B  70
VAL B  77
ALA B  96
TYR B 108
 None
 0.79A 3qxtB-5hvfB:
18.7		 3qxtB-5hvfB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5hvf VHH-I83
(Vicugna
pacos) 		7 / 12 VAL B   2
LEU B   4
ALA B  24
MET B  34
VAL B  77
ALA B  96
TYR B 108
 None
 0.94A 3qxtB-5hvfB:
18.7		 3qxtB-5hvfB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5hvf VHH-I83
(Vicugna
pacos) 		7 / 12 VAL B   2
ALA B  24
ARG B  70
ASN B  72
VAL B  77
ALA B  96
TYR B 108
 None
 0.91A 3qxvA-5hvfB:
18.7		 3qxvA-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5hvf VHH-I83
(Vicugna
pacos) 		7 / 12 VAL B   2
ALA B  24
MET B  34
ASN B  72
VAL B  77
ALA B  96
TYR B 108
 None
 1.10A 3qxvA-5hvfB:
18.7		 3qxvA-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5hvf VHH-I83
(Vicugna
pacos) 		5 / 12 VAL B   2
ALA B  24
ARG B  70
VAL B  77
TYR B 108
 None
 0.88A 3qxvB-5hvfB:
18.7		 3qxvB-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5hvf VHH-I83
(Vicugna
pacos) 		6 / 12 VAL B   2
ALA B  24
MET B  34
VAL B  77
ALA B  96
TYR B 108
 None
 1.01A 3qxvB-5hvfB:
18.7		 3qxvB-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5hvf VHH-I83
(Vicugna
pacos) 		6 / 11 VAL B   2
ALA B  24
MET B  34
ASN B  72
VAL B  77
ALA B  96
 None
 1.15A 3qxvC-5hvfB:
18.9		 3qxvC-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5hvf VHH-I83
(Vicugna
pacos) 		6 / 12 VAL B   2
ALA B  24
ARG B  70
VAL B  77
ALA B  96
TYR B 108
 None
 0.86A 3qxvD-5hvfB:
18.5		 3qxvD-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5hvf VHH-I83
(Vicugna
pacos) 		6 / 12 VAL B   2
ALA B  24
MET B  34
VAL B  77
ALA B  96
TYR B 108
 None
 0.95A 3qxvD-5hvfB:
18.5		 3qxvD-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5hvf VHH-I83
(Vicugna
pacos) 		5 / 12 ALA B  24
MET B  34
VAL B  77
ALA B  96
TYR B 108
 None
 1.00A 3qxvE-5hvfB:
15.1		 3qxvE-5hvfB:
69.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		3 / 3 ASP A  38
GLU A 245
GLY A 246
 None
 0.52A 3w9tA-5hvfA:
undetectable		 3w9tA-5hvfA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		3 / 3 TRP A 163
VAL A 203
TRP A 210
 None
 1.15A 3zq8A-5hvfA:
undetectable
3zq8B-5hvfA:
undetectable		 3zq8A-5hvfA:
3.07
3zq8B-5hvfA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 5hvf CARBOXYPEPTIDASE B2
VHH-I83
(Homo
sapiens;
Vicugna
pacos) 		4 / 5 GLY A 368
THR A 367
HIS A  47
GLY B  98
 None
 0.96A 4v20A-5hvfA:
undetectable		 4v20A-5hvfA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		3 / 3 GLU A 266
ILE A 229
ALA A 160
 None
 0.59A 4wnwB-5hvfA:
undetectable		 4wnwB-5hvfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 5 ARG A 235
ARG A 302
GLY A 336
GLU A 338
 FLC  A 509 (-2.8A)
None
None
None
 1.16A 4z3oA-5hvfA:
3.8
4z3oB-5hvfA:
4.3		 4z3oA-5hvfA:
20.11
4z3oB-5hvfA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 7 ARG A 235
ARG A 302
GLY A 336
GLU A 338
 FLC  A 509 (-2.8A)
None
None
None
 0.93A 5btaA-5hvfA:
3.4
5btaC-5hvfA:
2.9
5btaD-5hvfA:
2.9		 5btaA-5hvfA:
20.35
5btaC-5hvfA:
20.35
5btaD-5hvfA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 6 ARG A 302
GLY A 336
GLU A 338
ARG A 235
 None
None
None
FLC  A 509 (-2.8A)
 0.91A 5btaA-5hvfA:
3.4
5btaB-5hvfA:
3.1
5btaC-5hvfA:
undetectable		 5btaA-5hvfA:
20.35
5btaB-5hvfA:
19.55
5btaC-5hvfA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 6 ARG A 235
ARG A 302
GLY A 336
GLU A 338
 FLC  A 509 (-2.8A)
None
None
None
 0.94A 5btcA-5hvfA:
3.1
5btcC-5hvfA:
3.4
5btcD-5hvfA:
2.8		 5btcA-5hvfA:
20.35
5btcC-5hvfA:
20.35
5btcD-5hvfA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 6 ARG A 302
GLY A 336
GLU A 338
ARG A 235
 None
None
None
FLC  A 509 (-2.8A)
 0.91A 5btcA-5hvfA:
3.1
5btcB-5hvfA:
2.0
5btcC-5hvfA:
3.4		 5btcA-5hvfA:
20.35
5btcB-5hvfA:
19.55
5btcC-5hvfA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 7 ARG A 302
GLY A 336
GLU A 338
ARG A 235
 None
None
None
FLC  A 509 (-2.8A)
 0.92A 5btfA-5hvfA:
3.4
5btfB-5hvfA:
3.9
5btfC-5hvfA:
3.3		 5btfA-5hvfA:
20.35
5btfB-5hvfA:
19.55
5btfC-5hvfA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 6 ARG A 302
GLY A 336
GLU A 338
ARG A 235
 None
None
None
FLC  A 509 (-2.8A)
 0.85A 5btgA-5hvfA:
3.5
5btgB-5hvfA:
2.8
5btgC-5hvfA:
3.4		 5btgA-5hvfA:
19.77
5btgB-5hvfA:
19.55
5btgC-5hvfA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 5 ARG A 302
GLY A 336
GLU A 338
ARG A 235
 None
None
None
FLC  A 509 (-2.8A)
 1.12A 5cdqA-5hvfA:
undetectable
5cdqB-5hvfA:
3.7
5cdqC-5hvfA:
undetectable		 5cdqA-5hvfA:
22.50
5cdqB-5hvfA:
18.50
5cdqC-5hvfA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 5 ARG A 302
GLY A 336
GLU A 338
ARG A 235
 None
None
None
FLC  A 509 (-2.8A)
 1.16A 5cdqR-5hvfA:
undetectable
5cdqS-5hvfA:
undetectable
5cdqT-5hvfA:
undetectable		 5cdqR-5hvfA:
22.50
5cdqS-5hvfA:
18.50
5cdqT-5hvfA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JDC_D_6JPD302_1
(PTERIDINE REDUCTASE)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		5 / 11 HIS A 159
ARG A 275
ASP A 155
TYR A 284
VAL A 267
 ZN  A 508 ( 3.2A)
None
None
None
None
 1.46A 5jdcA-5hvfA:
undetectable
5jdcD-5hvfA:
undetectable		 5jdcA-5hvfA:
20.96
5jdcD-5hvfA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 8 THR A 367
THR A 369
PRO A 381
ILE A 329
 None
 1.12A 5jhdE-5hvfA:
undetectable
5jhdG-5hvfA:
undetectable		 5jhdE-5hvfA:
21.10
5jhdG-5hvfA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		5 / 12 LEU A  31
ASP A  54
VAL A  50
ILE A  67
ILE A  29
 None
 1.06A 5kqyA-5hvfA:
undetectable		 5kqyA-5hvfA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens) 		5 / 10 GLY A 347
SER A 286
ALA A 343
ARG A 235
HIS A 288
 None
None
FLC  A 509 (-3.2A)
FLC  A 509 (-2.8A)
ZN  A 508 (-3.1A)
 1.47A 6qgbD-5hvfA:
3.0		 6qgbD-5hvfA:
19.97