SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hvn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		5 / 9 THR A  86
LEU A  38
VAL A  39
ILE A 107
ILE A  67
 None
 1.18A 1gebA-5hvnA:
undetectable		 1gebA-5hvnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		4 / 8 SER A 299
ILE A 338
PHE A 190
SER A 279
 None
 1.07A 1kb9A-5hvnA:
undetectable
1kb9C-5hvnA:
undetectable
1kb9D-5hvnA:
undetectable
1kb9E-5hvnA:
undetectable		 1kb9A-5hvnA:
23.44
1kb9C-5hvnA:
22.09
1kb9D-5hvnA:
19.11
1kb9E-5hvnA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		5 / 12 ILE A 107
LEU A  99
GLY A 104
GLY A 103
THR A 111
 None
None
NAD  A 401 (-3.4A)
None
None
 1.10A 1likA-5hvnA:
undetectable		 1likA-5hvnA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		5 / 12 GLY A 246
GLY A 269
GLY A 271
ALA A 275
PHE A 300
 CL  A 402 (-3.7A)
None
None
CL  A 402 ( 4.4A)
None
 1.11A 2dpmA-5hvnA:
undetectable		 2dpmA-5hvnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		5 / 12 GLY A 104
GLU A 254
VAL A 268
ASP A 136
ASP A 109
 NAD  A 401 (-3.4A)
None
None
NAD  A 401 (-3.6A)
NAD  A 401 (-3.3A)
 1.22A 2vqyA-5hvnA:
undetectable		 2vqyA-5hvnA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		3 / 3 ASN A 202
TRP A 198
ASP A 210
 None
 1.30A 4a7tA-5hvnA:
undetectable
4a7tF-5hvnA:
undetectable		 4a7tA-5hvnA:
16.39
4a7tF-5hvnA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		3 / 3 HIS A 264
GLU A  72
ASN A 152
 NAD  A 401 ( 4.6A)
NAD  A 401 (-2.6A)
NAD  A 401 (-3.5A)
 0.68A 4bupB-5hvnA:
undetectable		 4bupB-5hvnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		5 / 11 ILE A 127
LEU A  50
PHE A  53
LEU A  57
THR A 129
 None
None
None
None
NAD  A 401 (-3.6A)
 1.34A 4i1nA-5hvnA:
undetectable		 4i1nA-5hvnA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		5 / 9 THR A 143
ILE A 107
VAL A  98
LEU A  99
ILE A 122
 None
 1.31A 4r38C-5hvnA:
undetectable		 4r38C-5hvnA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		4 / 7 ARG A 176
ILE A 179
GLN A 175
PRO A 174
 None
 1.04A 4w5oA-5hvnA:
3.9		 4w5oA-5hvnA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		3 / 3 ASP A 309
LEU A 262
GLY A 261
 None
 0.52A 4xmfA-5hvnA:
undetectable		 4xmfA-5hvnA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		4 / 7 ARG A 176
ILE A 179
GLN A 175
PRO A 174
 None
 1.03A 4z4eA-5hvnA:
undetectable		 4z4eA-5hvnA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		4 / 7 ARG A 176
ILE A 179
GLN A 175
PRO A 174
 None
 1.03A 4z4gA-5hvnA:
undetectable		 4z4gA-5hvnA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		5 / 12 GLY A 112
ILE A 145
LEU A  80
GLY A 155
GLY A 140
 None
 0.97A 5d4uA-5hvnA:
undetectable		 5d4uA-5hvnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		5 / 12 GLY A 112
ILE A 145
LEU A  80
GLY A 155
GLY A 140
 None
 0.99A 5d4uB-5hvnA:
undetectable		 5d4uB-5hvnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		5 / 12 GLY A 112
ILE A 145
LEU A  80
GLY A 155
GLY A 140
 None
 1.00A 5d4uC-5hvnA:
undetectable		 5d4uC-5hvnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		5 / 12 GLY A 112
ILE A 145
LEU A  80
GLY A 155
GLY A 140
 None
 0.99A 5d4uD-5hvnA:
undetectable		 5d4uD-5hvnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		5 / 12 LEU A 334
PHE A 332
LEU A 320
LEU A 316
PHE A 278
 None
 1.38A 5ieoA-5hvnA:
undetectable		 5ieoA-5hvnA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		4 / 5 ALA A 189
VAL A 185
PHE A 296
ILE A 206
 None
 0.95A 5of1A-5hvnA:
undetectable		 5of1A-5hvnA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		4 / 5 ALA A 189
VAL A 185
PHE A 296
ILE A 206
 None
 1.06A 5of1B-5hvnA:
undetectable		 5of1B-5hvnA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		3 / 3 HIS A 264
GLU A  72
ASN A 152
 NAD  A 401 ( 4.6A)
NAD  A 401 (-2.6A)
NAD  A 401 (-3.5A)
 0.69A 5wbvA-5hvnA:
undetectable		 5wbvA-5hvnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		3 / 3 HIS A 264
GLU A  72
ASN A 152
 NAD  A 401 ( 4.6A)
NAD  A 401 (-2.6A)
NAD  A 401 (-3.5A)
 0.68A 5wbvB-5hvnA:
undetectable		 5wbvB-5hvnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		4 / 8 PHE A  53
LEU A  29
VAL A  32
VAL A  63
 None
 1.08A 6cp4A-5hvnA:
undetectable		 6cp4A-5hvnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		5 / 10 PHE A 190
ASP A 277
GLY A 246
PHE A 245
ILE A 304
 None
None
CL  A 402 (-3.7A)
None
None
 1.18A 6ebpB-5hvnA:
undetectable		 6ebpB-5hvnA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5hvn 3-DEHYDROQUINATE
SYNTHASE
(Francisella
tularensis) 		5 / 10 PHE A 190
ASP A 277
GLY A 246
PHE A 245
ILE A 304
 None
None
CL  A 402 (-3.7A)
None
None
 1.22A 6ebpC-5hvnA:
undetectable		 6ebpC-5hvnA:
13.13