SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		4 / 7 GLY A 387
ALA A 415
THR A 211
SER A 417
 VDM  A 502 (-3.7A)
None
None
None
 0.90A 1c9sT-5hvoA:
undetectable
1c9sU-5hvoA:
undetectable		 1c9sT-5hvoA:
11.30
1c9sU-5hvoA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		3 / 3 TRP A 427
ARG A 385
PHE A 411
 None
 1.47A 1zeaH-5hvoA:
undetectable
1zeaL-5hvoA:
undetectable		 1zeaH-5hvoA:
18.83
1zeaL-5hvoA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		5 / 12 SER A 365
LEU A 281
ALA A 270
ILE A 269
ALA A 371
 None
 0.98A 2bxcA-5hvoA:
undetectable		 2bxcA-5hvoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		5 / 10 SER A 392
ALA A 414
ASN A 389
ALA A 412
ALA A 415
 None
None
UDP  A 501 ( 3.7A)
None
None
 1.18A 2r2vC-5hvoA:
undetectable
2r2vF-5hvoA:
undetectable
2r2vG-5hvoA:
undetectable		 2r2vC-5hvoA:
5.65
2r2vF-5hvoA:
5.65
2r2vG-5hvoA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		3 / 3 ALA A 371
ARG A 268
LYS A 275
 None
 0.81A 3kp3B-5hvoA:
undetectable		 3kp3B-5hvoA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		4 / 5 ARG A 126
PRO A 192
VAL A 193
ASP A 123
 None
 0.98A 3ufnA-5hvoA:
undetectable
3ufnB-5hvoA:
undetectable		 3ufnA-5hvoA:
14.41
3ufnB-5hvoA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		4 / 8 ASP A 205
SER A 478
ARG A 240
GLY A 143
 None
 0.83A 4af0A-5hvoA:
undetectable		 4af0A-5hvoA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		3 / 3 TYR A  96
HIS A 152
ARG A  19
 None
VDM  A 502 (-4.7A)
None
 1.22A 4e7bC-5hvoA:
1.1		 4e7bC-5hvoA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		3 / 3 SER A 100
TYR A 125
PRO A 106
 None
 0.73A 4k8cA-5hvoA:
4.7		 4k8cA-5hvoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		3 / 3 SER A 100
TYR A 125
PRO A 106
 None
 0.72A 4kahA-5hvoA:
4.1		 4kahA-5hvoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		3 / 3 SER A 100
TYR A 125
PRO A 106
 None
 0.71A 4kahB-5hvoA:
4.1		 4kahB-5hvoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		3 / 3 SER A 100
TYR A 125
PRO A 106
 None
 0.74A 4kanA-5hvoA:
5.1		 4kanA-5hvoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		3 / 3 SER A 100
TYR A 125
PRO A 106
 None
 0.72A 4kanB-5hvoA:
4.0		 4kanB-5hvoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		3 / 3 SER A 100
TYR A 125
PRO A 106
 None
 0.71A 4kbeA-5hvoA:
4.4		 4kbeA-5hvoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		3 / 3 SER A 100
TYR A 125
PRO A 106
 None
 0.72A 4kbeB-5hvoA:
4.5		 4kbeB-5hvoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		3 / 3 TYR A 331
ARG A 287
SER A 324
 None
VDM  A 502 (-3.6A)
VDM  A 502 ( 4.1A)
 1.03A 4khpI-5hvoA:
undetectable
4khpJ-5hvoA:
undetectable		 4khpI-5hvoA:
14.97
4khpJ-5hvoA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		3 / 3 SER A 100
TYR A 125
PRO A 106
 None
 0.72A 4lbgA-5hvoA:
4.2		 4lbgA-5hvoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		3 / 3 SER A 100
TYR A 125
PRO A 106
 None
 0.72A 4lbgB-5hvoA:
4.8		 4lbgB-5hvoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		4 / 5 ILE A  22
PRO A  21
HIS A 179
TYR A  96
 None
None
VDM  A 502 (-3.6A)
None
 1.26A 4s0vA-5hvoA:
6.4		 4s0vA-5hvoA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		4 / 4 SER A  46
SER A 463
GLU A 394
ASP A 252
 None
None
UDP  A 501 (-1.8A)
None
 1.31A 4ymgA-5hvoA:
3.7		 4ymgA-5hvoA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		4 / 5 PHE A 182
HIS A 224
LEU A 225
PRO A 183
 None
 1.40A 5csyB-5hvoA:
undetectable		 5csyB-5hvoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		5 / 12 GLY A 413
GLN A 416
PHE A 470
ILE A 146
GLY A 175
 None
 1.16A 5fsaB-5hvoA:
undetectable		 5fsaB-5hvoA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Aspergillus
fumigatus) 		5 / 12 PHE A 218
LEU A 191
ILE A 187
LEU A 202
LEU A 226
 None
 1.23A 5ycpA-5hvoA:
undetectable		 5ycpA-5hvoA:
10.42