SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hw3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		5 / 12 LEU A 206
ILE A  80
ALA A  77
THR A 161
TYR A 261
 None
 1.06A 1cbsA-5hw3A:
undetectable		 1cbsA-5hw3A:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 SER A  70
LYS A  73
SER A 131
ASN A 133
GLU A 167
GLY A 235
 SO4  A 301 (-2.7A)
None
SO4  A 301 (-2.6A)
None
None
SO4  A 301 (-3.4A)
 0.75A 1i2wA-5hw3A:
38.7		 1i2wA-5hw3A:
33.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		7 / 12 SER A  70
LYS A  73
SER A 131
ASN A 133
GLU A 167
GLY A 235
ARG A 219
 SO4  A 301 (-2.7A)
None
SO4  A 301 (-2.6A)
None
None
SO4  A 301 (-3.4A)
SO4  A 301 ( 4.2A)
 1.09A 1i2wB-5hw3A:
38.8		 1i2wB-5hw3A:
33.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		5 / 12 GLY A  55
LEU A 193
ARG A 249
ALA A 186
LEU A 194
 None
 1.27A 1jipA-5hw3A:
undetectable		 1jipA-5hw3A:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		7 / 12 SER A  70
LYS A  73
SER A 131
ASN A 133
GLU A 167
ASN A 171
GLY A 235
 SO4  A 301 (-2.7A)
None
SO4  A 301 (-2.6A)
None
None
ACT  A 310 (-4.0A)
SO4  A 301 (-3.4A)
 0.96A 1ymxB-5hw3A:
40.0		 1ymxB-5hw3A:
38.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		5 / 12 LEU A 206
ILE A  80
ALA A  77
THR A 161
TYR A 261
 None
 1.09A 2fr3A-5hw3A:
undetectable		 2fr3A-5hw3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		3 / 3 ASN A 243
TYR A 173
SER A 237
 None
None
ACT  A 310 (-4.8A)
 0.90A 2gvcB-5hw3A:
undetectable		 2gvcB-5hw3A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		3 / 3 ASN A 243
TYR A 173
SER A 237
 None
None
ACT  A 310 (-4.8A)
 0.89A 2gvcE-5hw3A:
undetectable		 2gvcE-5hw3A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		4 / 7 GLY A 145
GLY A 144
ALA A 147
ALA A 148
 None
 0.65A 2ha4B-5hw3A:
undetectable		 2ha4B-5hw3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		4 / 7 PHE A  48
TYR A 245
PRO A 182
THR A 180
 None
 1.08A 2q6kA-5hw3A:
undetectable		 2q6kA-5hw3A:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		5 / 12 CYH A  69
LYS A  73
ASN A 133
ASN A 171
GLY A 235
 None
None
None
ACT  A 310 (-4.0A)
SO4  A 301 (-3.4A)
 0.56A 3huoA-5hw3A:
39.9		 3huoA-5hw3A:
37.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		5 / 6 THR A  52
LEU A 194
GLY A 195
ALA A 254
PRO A 255
 None
 0.31A 3huoA-5hw3A:
39.9		 3huoA-5hw3A:
37.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		5 / 12 CYH A  69
LYS A  73
ASN A 133
ASN A 171
GLY A 235
 None
None
None
ACT  A 310 (-4.0A)
SO4  A 301 (-3.4A)
 0.52A 3huoB-5hw3A:
39.7		 3huoB-5hw3A:
37.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		4 / 6 VAL A 197
ARG A 203
LEU A 198
LEU A 206
 None
 0.92A 3kp6A-5hw3A:
undetectable
3kp6B-5hw3A:
1.8		 3kp6A-5hw3A:
19.05
3kp6B-5hw3A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		5 / 11 PRO A  33
VAL A 260
ALA A 259
ILE A 220
ARG A  56
 None
 1.27A 3n23A-5hw3A:
undetectable		 3n23A-5hw3A:
15.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 SER A  70
SER A 131
ASN A 171
ARG A 219
GLY A 235
THR A 236
 SO4  A 301 (-2.7A)
SO4  A 301 (-2.6A)
ACT  A 310 (-4.0A)
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
 0.39A 3ny4A-5hw3A:
38.2		 3ny4A-5hw3A:
42.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		5 / 12 LEU A  75
ALA A  77
MET A 210
LEU A 128
ILE A 185
 None
 1.23A 3olsB-5hw3A:
undetectable		 3olsB-5hw3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		3 / 3 LEU A 217
ARG A 219
MET A  68
 None
SO4  A 301 ( 4.2A)
None
 0.80A 4m11C-5hw3A:
undetectable		 4m11C-5hw3A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		4 / 7 TYR A 245
THR A 134
THR A 109
THR A 236
 None
None
None
SO4  A 301 (-3.5A)
 1.10A 4mbsA-5hw3A:
undetectable		 4mbsA-5hw3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		3 / 3 LYS A 183
ASN A 243
ASP A  63
 None
 0.87A 4o1eA-5hw3A:
undetectable		 4o1eA-5hw3A:
23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM7_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		5 / 12 LYS A  73
SER A 131
ASN A 133
ASN A 171
GLY A 235
 None
SO4  A 301 (-2.6A)
None
ACT  A 310 (-4.0A)
SO4  A 301 (-3.4A)
 0.71A 4pm7A-5hw3A:
39.8		 4pm7A-5hw3A:
37.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		5 / 12 ILE A 220
TYR A 245
THR A 161
ALA A 184
ALA A 187
 None
 1.49A 4u14A-5hw3A:
undetectable		 4u14A-5hw3A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		4 / 7 SER A  70
ARG A 165
SER A 170
GLU A 167
 SO4  A 301 (-2.7A)
None
None
None
 1.32A 4xzkA-5hw3A:
undetectable		 4xzkA-5hw3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		4 / 5 VAL A 176
ILE A 120
PRO A 146
THR A 134
 None
 1.27A 4ze1A-5hw3A:
undetectable		 4ze1A-5hw3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		3 / 3 ASP A 232
ASN A 243
PHE A  72
 None
 0.69A 5dsgB-5hw3A:
undetectable		 5dsgB-5hw3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		4 / 8 SER A 106
THR A 109
PRO A 168
ILE A 137
 None
 1.05A 5jhdE-5hw3A:
undetectable
5jhdG-5hw3A:
undetectable		 5jhdE-5hw3A:
22.49
5jhdG-5hw3A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 LEU A  76
ALA A  77
MET A 210
LEU A 128
ILE A 185
LEU A 192
 None
 1.50A 5toaA-5hw3A:
undetectable		 5toaA-5hw3A:
22.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 CYH A  69
SER A  70
ASN A 171
ARG A 219
GLY A 235
THR A 236
 None
SO4  A 301 (-2.7A)
ACT  A 310 (-4.0A)
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
 0.44A 6b5yB-5hw3A:
38.5		 6b5yB-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 CYH A  69
SER A  70
SER A 131
ARG A 219
GLY A 235
THR A 236
 None
SO4  A 301 (-2.7A)
SO4  A 301 (-2.6A)
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
 0.52A 6b5yB-5hw3A:
38.5		 6b5yB-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 CYH A  69
SER A  70
ASN A 171
GLY A 235
THR A 236
GLU A 273
 None
SO4  A 301 (-2.7A)
ACT  A 310 (-4.0A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
None
 0.31A 6b5yD-5hw3A:
38.6		 6b5yD-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 CYH A  69
SER A  70
SER A 131
GLY A 235
THR A 236
GLU A 273
 None
SO4  A 301 (-2.7A)
SO4  A 301 (-2.6A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
None
 0.45A 6b5yD-5hw3A:
38.6		 6b5yD-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 CYH A  69
SER A  70
ASN A 171
ARG A 172
GLY A 235
THR A 236
 None
SO4  A 301 (-2.7A)
ACT  A 310 (-4.0A)
None
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
 0.62A 6b68B-5hw3A:
38.6		 6b68B-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 CYH A  69
SER A  70
SER A 131
ASN A 171
GLY A 235
THR A 236
 None
SO4  A 301 (-2.7A)
SO4  A 301 (-2.6A)
ACT  A 310 (-4.0A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
 0.56A 6b68B-5hw3A:
38.6		 6b68B-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 SER A  70
ASN A 171
ARG A 219
GLY A 235
THR A 236
GLU A 273
 SO4  A 301 (-2.7A)
ACT  A 310 (-4.0A)
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
None
 0.27A 6b68D-5hw3A:
38.4		 6b68D-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 SER A  70
SER A 131
ARG A 219
GLY A 235
THR A 236
GLU A 273
 SO4  A 301 (-2.7A)
SO4  A 301 (-2.6A)
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
None
 0.49A 6b68D-5hw3A:
38.4		 6b68D-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		7 / 12 CYH A  69
SER A  70
ASN A 171
ARG A 219
GLY A 235
THR A 236
GLU A 273
 None
SO4  A 301 (-2.7A)
ACT  A 310 (-4.0A)
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
None
 0.31A 6b69D-5hw3A:
38.4		 6b69D-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		7 / 12 CYH A  69
SER A  70
SER A 131
ARG A 219
GLY A 235
THR A 236
GLU A 273
 None
SO4  A 301 (-2.7A)
SO4  A 301 (-2.6A)
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
None
 0.46A 6b69D-5hw3A:
38.4		 6b69D-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 CYH A  69
SER A  70
ASN A 171
ARG A 219
GLY A 235
THR A 236
 None
SO4  A 301 (-2.7A)
ACT  A 310 (-4.0A)
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
 0.31A 6b6aB-5hw3A:
38.5		 6b6aB-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 CYH A  69
SER A  70
SER A 131
ARG A 219
GLY A 235
THR A 236
 None
SO4  A 301 (-2.7A)
SO4  A 301 (-2.6A)
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
 0.47A 6b6aB-5hw3A:
38.5		 6b6aB-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 SER A  70
ASN A 171
ARG A 219
GLY A 235
THR A 236
GLU A 273
 SO4  A 301 (-2.7A)
ACT  A 310 (-4.0A)
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
None
 0.33A 6b6aD-5hw3A:
38.3		 6b6aD-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 SER A  70
SER A 131
ARG A 219
GLY A 235
THR A 236
GLU A 273
 SO4  A 301 (-2.7A)
SO4  A 301 (-2.6A)
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
None
 0.45A 6b6aD-5hw3A:
38.3		 6b6aD-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		7 / 12 SER A  70
PRO A 168
ASN A 171
ARG A 172
ARG A 219
GLY A 235
THR A 236
 SO4  A 301 (-2.7A)
None
ACT  A 310 (-4.0A)
None
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
 0.65A 6b6cA-5hw3A:
38.4		 6b6cA-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		7 / 12 CYH A  69
SER A  70
SER A 131
ASN A 171
ARG A 172
GLY A 235
THR A 236
 None
SO4  A 301 (-2.7A)
SO4  A 301 (-2.6A)
ACT  A 310 (-4.0A)
None
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
 0.74A 6b6dA-5hw3A:
38.3		 6b6dA-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 SER A  70
ASN A 171
ARG A 172
ARG A 219
GLY A 235
THR A 236
 SO4  A 301 (-2.7A)
ACT  A 310 (-4.0A)
None
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
 0.55A 6b6eA-5hw3A:
38.5		 6b6eA-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 SER A  70
SER A 131
ASN A 171
ARG A 219
GLY A 235
THR A 236
 SO4  A 301 (-2.7A)
SO4  A 301 (-2.6A)
ACT  A 310 (-4.0A)
SO4  A 301 ( 4.2A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
 0.55A 6b6eA-5hw3A:
38.5		 6b6eA-5hw3A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		6 / 12 CYH A  69
SER A  70
PRO A 168
ASN A 171
GLY A 235
THR A 236
 None
SO4  A 301 (-2.7A)
None
ACT  A 310 (-4.0A)
SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
 0.36A 6b6fA-5hw3A:
38.0		 6b6fA-5hw3A:
40.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		4 / 7 SER A 163
GLY A 144
ALA A 143
VAL A  95
 None
None
None
SO4  A 306 ( 3.7A)
 0.84A 6dwnB-5hw3A:
undetectable		 6dwnB-5hw3A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5hw3 BETA-LACTAMASE
(Burkholderia
vietnamiensis) 		4 / 6 ASP A 239
ARG A 240
GLU A 241
ASP A 263
 SO4  A 303 (-2.7A)
SO4  A 303 (-4.0A)
None
None
 1.48A 6mn5D-5hw3A:
undetectable		 6mn5D-5hw3A:
16.10