SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hw4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXC_A_ROCA401_3 (PROTEASE)	5hw4	RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I (Escherichia coli)	5 / 12	ARG A 190 GLY A 133 ALA A 132 ILE A 126 ILE A 231	None	1.04A	3oxcB-5hw4A: undetectable	3oxcB-5hw4A: 16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SU9_A_ACTA426_0 (UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE)	5hw4	RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I (Escherichia coli)	3 / 3	GLN A 71 GLU A 70 LYS A 70	None	1.05A	3su9A-5hw4A: undetectable	3su9A-5hw4A: 23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UVV_A_T3A501_1 (THYROID HORMONE RECEPTOR ALPHA)	5hw4	RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I (Escherichia coli)	5 / 12	ILE A 41 ALA A 88 ALA A 31 LEU A 52 ILE A 27	None	1.05A	3uvvA-5hw4A: undetectable	3uvvA-5hw4A: 22.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HW4_A_SAMA801_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I)	5hw4	RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I (Escherichia coli)	12 / 12	ILE A 21 GLY A 94 THR A 95 ASP A 100 CYH A 123 ALA A 124 PHE A 144 TYR A 169 LEU A 198 LYS A 200 GLU A 227 VAL A 229	SAM A 801 (-4.0A) SAM A 801 (-3.7A) SAM A 801 (-4.4A) SAM A 801 (-3.7A) SAM A 801 ( 3.7A) SAM A 801 (-3.3A) SAM A 801 (-4.7A) SAM A 801 (-3.5A) SAM A 801 (-3.8A) SAM A 801 ( 4.4A) SAM A 801 (-3.6A) SAM A 801 (-4.5A)	0.01A	5hw4A-5hw4A: 38.3	5hw4A-5hw4A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HW4_B_SAMB801_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I)	5hw4	RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I (Escherichia coli)	11 / 11	ILE A 21 GLY A 94 ASP A 100 CYH A 123 ALA A 124 PHE A 144 TYR A 169 LEU A 198 LYS A 200 GLU A 227 VAL A 229	SAM A 801 (-4.0A) SAM A 801 (-3.7A) SAM A 801 (-3.7A) SAM A 801 ( 3.7A) SAM A 801 (-3.3A) SAM A 801 (-4.7A) SAM A 801 (-3.5A) SAM A 801 (-3.8A) SAM A 801 ( 4.4A) SAM A 801 (-3.6A) SAM A 801 (-4.5A)	0.21A	5hw4B-5hw4A: 34.6	5hw4B-5hw4A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HW4_C_SAMC801_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I)	5hw4	RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I (Escherichia coli)	12 / 12	ILE A 21 GLY A 94 THR A 95 ASP A 100 CYH A 123 ALA A 124 PHE A 144 TYR A 169 LEU A 198 LYS A 200 GLU A 227 VAL A 229	SAM A 801 (-4.0A) SAM A 801 (-3.7A) SAM A 801 (-4.4A) SAM A 801 (-3.7A) SAM A 801 ( 3.7A) SAM A 801 (-3.3A) SAM A 801 (-4.7A) SAM A 801 (-3.5A) SAM A 801 (-3.8A) SAM A 801 ( 4.4A) SAM A 801 (-3.6A) SAM A 801 (-4.5A)	0.14A	5hw4C-5hw4A: 35.3	5hw4C-5hw4A: 100.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3OXC_A_ROCA401_3","PROTEASE;PROTEASE","5hw4","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I","Escherichia coli",5,"ARG A 190;GLY A 133;ALA A 132;ILE A 126;ILE A 231","None","1.04A","3oxcB-5hw4A:undetectable","3oxcB-5hw4A:16.53"],["3SU9_A_ACTA426_0","UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE","5hw4","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I","Escherichia coli",3,"GLN A  71;GLU A  70;LYS A  70","None","1.05A","3su9A-5hw4A:undetectable","3su9A-5hw4A:23.46"],["3UVV_A_T3A501_1","THYROID HORMONE RECEPTOR ALPHA","5hw4","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I","Escherichia coli",5,"ILE A  41;ALA A  88;ALA A  31;LEU A  52;ILE A  27","None","1.05A","3uvvA-5hw4A:undetectable","3uvvA-5hw4A:22.84"],["5HW4_A_SAMA801_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I","5hw4","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I","Escherichia coli",12,"ILE A  21;GLY A  94;THR A  95;ASP A 100;CYH A 123;ALA A 124;PHE A 144;TYR A 169;LEU A 198;LYS A 200;GLU A 227;VAL A 229","SAM A 801 (-4.0A);SAM A 801 (-3.7A);SAM A 801 (-4.4A);SAM A 801 (-3.7A);SAM A 801 ( 3.7A);SAM A 801 (-3.3A);SAM A 801 (-4.7A);SAM A 801 (-3.5A);SAM A 801 (-3.8A);SAM A 801 ( 4.4A);SAM A 801 (-3.6A);SAM A 801 (-4.5A)","0.01A","5hw4A-5hw4A:38.3","5hw4A-5hw4A:100.00"],["5HW4_B_SAMB801_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I","5hw4","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I","Escherichia coli",11,"ILE A  21;GLY A  94;ASP A 100;CYH A 123;ALA A 124;PHE A 144;TYR A 169;LEU A 198;LYS A 200;GLU A 227;VAL A 229","SAM A 801 (-4.0A);SAM A 801 (-3.7A);SAM A 801 (-3.7A);SAM A 801 ( 3.7A);SAM A 801 (-3.3A);SAM A 801 (-4.7A);SAM A 801 (-3.5A);SAM A 801 (-3.8A);SAM A 801 ( 4.4A);SAM A 801 (-3.6A);SAM A 801 (-4.5A)","0.21A","5hw4B-5hw4A:34.6","5hw4B-5hw4A:100.00"],["5HW4_C_SAMC801_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I","5hw4","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I","Escherichia coli",12,"ILE A  21;GLY A  94;THR A  95;ASP A 100;CYH A 123;ALA A 124;PHE A 144;TYR A 169;LEU A 198;LYS A 200;GLU A 227;VAL A 229","SAM A 801 (-4.0A);SAM A 801 (-3.7A);SAM A 801 (-4.4A);SAM A 801 (-3.7A);SAM A 801 ( 3.7A);SAM A 801 (-3.3A);SAM A 801 (-4.7A);SAM A 801 (-3.5A);SAM A 801 (-3.8A);SAM A 801 ( 4.4A);SAM A 801 (-3.6A);SAM A 801 (-4.5A)","0.14A","5hw4C-5hw4A:35.3","5hw4C-5hw4A:100.00"]]