SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hwi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  17
ASN A 131
LEU A 204
ILE A  93
LEU A  11
 None
 1.21A 3a50A-5hwiA:
undetectable		 3a50A-5hwiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  17
ASN A 131
LEU A 204
ILE A  93
LEU A  11
 None
 1.21A 3a50C-5hwiA:
undetectable		 3a50C-5hwiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  17
ASN A 131
LEU A 204
ILE A  93
LEU A  11
 None
 1.26A 3a50E-5hwiA:
undetectable		 3a50E-5hwiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  17
ASN A 131
LEU A 204
ILE A  93
LEU A  11
 None
 1.26A 3a51A-5hwiA:
undetectable		 3a51A-5hwiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A  81
ARG A  38
ILE A  84
GLU A  80
 None
 1.13A 4cx7A-5hwiA:
undetectable
4cx7B-5hwiA:
undetectable		 4cx7A-5hwiA:
20.19
4cx7B-5hwiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A  81
ARG A  38
ILE A  84
GLU A  80
 None
 1.16A 4cx7C-5hwiA:
undetectable
4cx7D-5hwiA:
undetectable		 4cx7C-5hwiA:
20.19
4cx7D-5hwiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A  78
ILE A  65
ILE A  60
ALA A  36
 None
 0.78A 4lv9B-5hwiA:
undetectable		 4lv9B-5hwiA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 MET A 141
LEU A 142
ILE A  28
VAL A  96
LEU A  11
 None
 1.18A 4m11A-5hwiA:
undetectable		 4m11A-5hwiA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 MET A 141
ILE A  28
VAL A  96
LEU A  11
VAL A 124
 None
 1.40A 4m11D-5hwiA:
undetectable		 4m11D-5hwiA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  32
LEU A 156
GLY A  14
THR A 158
LEU A 204
 None
None
SIN  A 301 (-3.1A)
None
None
 1.05A 5byjA-5hwiA:
undetectable		 5byjA-5hwiA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A  12
LEU A  16
ARG A 114
TYR A 119
TYR A 161
 SIN  A 301 (-3.2A)
SIN  A 301 (-3.8A)
None
SIN  A 301 ( 4.7A)
None
 0.78A 5hwkA-5hwiA:
30.3		 5hwkA-5hwiA:
98.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		7 / 10 GLY A  12
TYR A  13
GLY A  14
SER A  15
LEU A  16
TYR A 119
TYR A 161
 SIN  A 301 (-3.2A)
SIN  A 301 (-3.5A)
SIN  A 301 (-3.1A)
SIN  A 301 (-2.8A)
SIN  A 301 (-3.8A)
SIN  A 301 ( 4.7A)
None
 0.36A 5hwkA-5hwiA:
30.3		 5hwkA-5hwiA:
98.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A  12
LEU A  16
ARG A 114
TYR A 119
TYR A 161
 SIN  A 301 (-3.2A)
SIN  A 301 (-3.8A)
None
SIN  A 301 ( 4.7A)
None
 0.78A 5hwkB-5hwiA:
30.1		 5hwkB-5hwiA:
98.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		7 / 10 GLY A  12
TYR A  13
GLY A  14
SER A  15
LEU A  16
TYR A 119
TYR A 161
 SIN  A 301 (-3.2A)
SIN  A 301 (-3.5A)
SIN  A 301 (-3.1A)
SIN  A 301 (-2.8A)
SIN  A 301 (-3.8A)
SIN  A 301 ( 4.7A)
None
 0.36A 5hwkB-5hwiA:
30.1		 5hwkB-5hwiA:
98.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  99
LEU A  11
LEU A 157
SER A 159
GLU A 123
 None
 1.37A 5tixB-5hwiA:
undetectable		 5tixB-5hwiA:
19.71