SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		4 / 7 THR A 240
GLU A 242
THR A 244
VAL A 196
 None
 1.11A 1tv8A-5hwsA:
undetectable		 1tv8A-5hwsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 11 LEU A 290
ALA A 293
LYS A 294
LEU A 194
VAL A 193
 None
 1.01A 2bxeB-5hwsA:
undetectable		 2bxeB-5hwsA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 10 LEU A 290
ALA A 293
LYS A 294
LEU A 194
VAL A 193
 None
 0.98A 2bxgB-5hwsA:
undetectable		 2bxgB-5hwsA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 10 LEU A  18
GLY A  16
LEU A  14
ILE A  11
ILE A 165
 None
None
None
NAP  A 401 (-3.9A)
None
 0.96A 2f8dA-5hwsA:
undetectable		 2f8dA-5hwsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 10 LEU A  18
GLY A  16
LEU A  14
ILE A  11
ILE A 165
 None
None
None
NAP  A 401 (-3.9A)
None
 0.99A 2f8dB-5hwsA:
undetectable		 2f8dB-5hwsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		4 / 8 THR A 240
GLU A 242
THR A 244
VAL A 196
 None
 1.11A 2fb2A-5hwsA:
undetectable		 2fb2A-5hwsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		4 / 7 THR A 240
GLU A 242
THR A 244
VAL A 196
 None
 1.13A 2fb2B-5hwsA:
undetectable		 2fb2B-5hwsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 6 PHE A  15
ILE A  70
PHE A 160
GLY A 118
GLY A 117
 None
 1.33A 2qx6A-5hwsA:
4.3
2qx6B-5hwsA:
4.4		 2qx6A-5hwsA:
20.62
2qx6B-5hwsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		4 / 6 PHE A  15
GLY A  12
ALA A  72
LEU A  28
 None
 1.00A 3bgdA-5hwsA:
4.5		 3bgdA-5hwsA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		4 / 7 VAL A   5
ILE A  38
THR A  52
GLY A  16
 None
 1.01A 3gssA-5hwsA:
undetectable		 3gssA-5hwsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A  18
LEU A  43
ILE A  11
GLY A 123
ALA A 124
 None
None
NAP  A 401 (-3.9A)
NAP  A 401 (-3.7A)
NAP  A 401 (-3.7A)
 1.07A 3n8xB-5hwsA:
undetectable		 3n8xB-5hwsA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 237
ILE A 210
ILE A 187
ILE A 214
ASP A 204
 None
 1.26A 3uj7A-5hwsA:
4.6		 3uj7A-5hwsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		4 / 5 GLY A 101
TYR A  76
TYR A 265
GLU A 260
 None
 1.29A 4ae1B-5hwsA:
undetectable		 4ae1B-5hwsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 11 VAL A 159
ALA A 163
PHE A  15
LEU A  96
VAL A 156
 None
 1.40A 4eilE-5hwsA:
undetectable		 4eilE-5hwsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 9 GLY A 118
GLY A 117
PHE A  15
ILE A  70
PHE A 160
 None
 1.34A 4fgjA-5hwsA:
4.3
4fgjB-5hwsA:
4.4		 4fgjA-5hwsA:
20.62
4fgjB-5hwsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 11 PHE A  15
ILE A  70
PHE A 160
GLY A 118
GLY A 117
 None
 1.35A 4fglA-5hwsA:
4.4
4fglB-5hwsA:
undetectable		 4fglA-5hwsA:
20.62
4fglB-5hwsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A 102
TYR A 265
GLU A 272
TYR A 273
 None
 1.21A 4z4gA-5hwsA:
2.1		 4z4gA-5hwsA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 118
GLY A 117
PHE A  15
ILE A  70
PHE A 160
 None
 1.27A 4zvmA-5hwsA:
4.3
4zvmB-5hwsA:
4.7		 4zvmA-5hwsA:
20.62
4zvmB-5hwsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 11 VAL A 159
LEU A  96
PHE A 152
MET A   1
GLY A 143
 None
 1.40A 5g6sA-5hwsA:
15.0
5g6sG-5hwsA:
15.0		 5g6sA-5hwsA:
26.14
5g6sG-5hwsA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 12 MET A   1
GLY A 143
VAL A 159
LEU A  96
PHE A 152
 None
 1.39A 5g6sB-5hwsA:
15.1
5g6sC-5hwsA:
15.0		 5g6sB-5hwsA:
26.14
5g6sC-5hwsA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 10 GLY A 118
GLY A 117
PHE A  15
ILE A  70
PHE A 160
 None
 1.31A 5lbtA-5hwsA:
4.4
5lbtB-5hwsA:
4.3		 5lbtA-5hwsA:
20.86
5lbtB-5hwsA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		5 / 12 ALA A 293
LEU A 290
VAL A 263
ASP A 264
GLY A 268
 None
 1.02A 5x24A-5hwsA:
undetectable		 5x24A-5hwsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5hws 2-DEHYDROPANTOATE
2-REDUCTASE
(Thermococcus
kodakarensis) 		4 / 6 TYR A 111
ILE A  89
ALA A  85
ARG A  86
 None
 1.15A 6hu9m-5hwsA:
undetectable
6hu9q-5hwsA:
undetectable		 6hu9m-5hwsA:
21.11
6hu9q-5hwsA:
18.90