SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 6 ILE A 114
TRP A  84
PHE A 128
GLU A  45
 None
 1.36A 1nsiA-5hwtA:
undetectable
1nsiB-5hwtA:
undetectable		 1nsiA-5hwtA:
15.97
1nsiB-5hwtA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 6 PHE A 128
GLU A  45
ILE A 114
TRP A  84
 None
 1.39A 1nsiA-5hwtA:
undetectable
1nsiB-5hwtA:
undetectable		 1nsiA-5hwtA:
15.97
1nsiB-5hwtA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 6 ILE A 114
TRP A  84
PHE A 128
GLU A  45
 None
 1.35A 1nsiC-5hwtA:
undetectable
1nsiD-5hwtA:
undetectable		 1nsiC-5hwtA:
15.97
1nsiD-5hwtA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 6 PHE A 128
GLU A  45
ILE A 114
TRP A  84
 None
 1.32A 1nsiC-5hwtA:
undetectable
1nsiD-5hwtA:
undetectable		 1nsiC-5hwtA:
15.97
1nsiD-5hwtA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 7 ILE A 114
TRP A  84
PHE A 128
GLU A  45
 None
 1.31A 2nsiA-5hwtA:
undetectable
2nsiB-5hwtA:
undetectable		 2nsiA-5hwtA:
15.97
2nsiB-5hwtA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 7 PHE A 128
GLU A  45
ILE A 114
TRP A  84
 None
 1.34A 2nsiA-5hwtA:
undetectable
2nsiB-5hwtA:
undetectable		 2nsiA-5hwtA:
15.97
2nsiB-5hwtA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 7 ILE A 114
TRP A  84
PHE A 128
GLU A  45
 None
 1.32A 2nsiC-5hwtA:
undetectable
2nsiD-5hwtA:
undetectable		 2nsiC-5hwtA:
15.97
2nsiD-5hwtA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 7 PHE A 128
GLU A  45
ILE A 114
TRP A  84
 None
 1.31A 2nsiC-5hwtA:
undetectable
2nsiD-5hwtA:
undetectable		 2nsiC-5hwtA:
15.97
2nsiD-5hwtA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 7 ILE A 114
TRP A  84
PHE A 128
GLU A  45
 None
 1.36A 3e7gA-5hwtA:
undetectable
3e7gB-5hwtA:
undetectable		 3e7gA-5hwtA:
16.35
3e7gB-5hwtA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 7 PHE A 128
GLU A  45
ILE A 114
TRP A  84
 None
 1.37A 3e7gA-5hwtA:
undetectable
3e7gB-5hwtA:
undetectable		 3e7gA-5hwtA:
16.35
3e7gB-5hwtA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 7 ILE A 114
TRP A  84
PHE A 128
GLU A  45
 None
 1.34A 3e7gC-5hwtA:
undetectable
3e7gD-5hwtA:
undetectable		 3e7gC-5hwtA:
16.35
3e7gD-5hwtA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 8 PHE A 128
GLU A  45
ILE A 114
TRP A  84
 None
 1.34A 4cx7A-5hwtA:
undetectable
4cx7B-5hwtA:
undetectable		 4cx7A-5hwtA:
15.97
4cx7B-5hwtA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 7 PHE A 128
GLU A  45
ILE A 114
TRP A  84
 None
 1.38A 4cx7C-5hwtA:
undetectable
4cx7D-5hwtA:
undetectable		 4cx7C-5hwtA:
15.97
4cx7D-5hwtA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		3 / 3 ARG A  83
TRP A  84
GLY A  67
 None
 0.95A 4e7cA-5hwtA:
undetectable		 4e7cA-5hwtA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		5 / 11 TRP A  85
LEU A  98
ASP A 127
GLY A 147
PHE A  46
 None
 1.46A 4foxC-5hwtA:
undetectable		 4foxC-5hwtA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 7 PHE A 128
GLU A  45
ILE A 114
TRP A  84
 None
 1.39A 4nosA-5hwtA:
undetectable
4nosB-5hwtA:
undetectable		 4nosA-5hwtA:
16.55
4nosB-5hwtA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 7 ILE A 114
TRP A  84
PHE A 128
GLU A  45
 None
 1.41A 4nosC-5hwtA:
undetectable
4nosD-5hwtA:
undetectable		 4nosC-5hwtA:
16.55
4nosD-5hwtA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 6 PHE A 128
GLU A  45
ILE A 114
TRP A  84
 None
 1.37A 4nosC-5hwtA:
undetectable
4nosD-5hwtA:
undetectable		 4nosC-5hwtA:
16.55
4nosD-5hwtA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		4 / 7 LEU A  64
ILE A 124
ILE A 114
VAL A 126
 None
 0.83A 4ojbA-5hwtA:
undetectable		 4ojbA-5hwtA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5hwt SENSOR HISTIDINE
KINASE TODS
(Pseudomonas
putida) 		3 / 3 LYS A  77
PRO A  78
LYS A  81
 None
 1.21A 5y9yA-5hwtA:
undetectable		 5y9yA-5hwtA:
18.59