SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hx0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		4 / 7 PHE A 382
SER A 394
SER A 379
ALA A 392
 None
 0.97A 1fxhA-5hx0A:
undetectable
1fxhB-5hx0A:
undetectable		 1fxhA-5hx0A:
19.90
1fxhB-5hx0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		5 / 12 GLY A 294
GLY A 295
VAL A 252
LEU A 218
LEU A 236
 ACT  A 403 (-3.9A)
None
None
ACT  A 403 ( 4.9A)
None
 0.67A 1mx1F-5hx0A:
undetectable		 1mx1F-5hx0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		4 / 6 TYR A 365
TYR A 381
HIS A  54
GLU A 262
 ACT  A 402 (-4.5A)
None
None
ACT  A 402 ( 4.6A)
 1.31A 1q13A-5hx0A:
undetectable		 1q13A-5hx0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_C_SPMC501_1
(SPERMINE SYNTHASE)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		5 / 10 VAL A 221
ASN A 205
TYR A 139
ASP A 123
GLU A 191
 None
None
None
ACT  A 402 (-2.9A)
None
 1.31A 3c6mC-5hx0A:
undetectable		 3c6mC-5hx0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		3 / 3 TYR A 381
ASP A 123
HIS A 309
 None
ACT  A 402 (-2.9A)
None
 0.91A 3e23A-5hx0A:
undetectable		 3e23A-5hx0A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		3 / 3 HIS A  88
PHE A 164
PHE A 157
 ACT  A 402 (-4.2A)
PG4  A 401 ( 4.1A)
PG4  A 401 (-3.6A)
 0.79A 3lk0D-5hx0A:
undetectable		 3lk0D-5hx0A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		5 / 12 ALA A 286
GLU A 302
ILE A 288
ASP A 345
LEU A 339
 None
 1.23A 3nrrA-5hx0A:
undetectable		 3nrrA-5hx0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		4 / 8 SER A  93
ASN A  92
GLY A 140
GLN A 122
 None
None
None
ACT  A 402 (-4.1A)
 0.99A 4af0A-5hx0A:
undetectable		 4af0A-5hx0A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		4 / 7 GLY A 281
ASP A 284
GLY A 283
HIS A 329
 None
 0.75A 4c5nA-5hx0A:
undetectable		 4c5nA-5hx0A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		5 / 12 GLU A 302
ILE A 288
ASP A 345
LEU A 339
ALA A 341
 None
 1.22A 4foxD-5hx0A:
undetectable		 4foxD-5hx0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		4 / 8 ASP A 293
SER A 291
ALA A 250
SER A 249
 None
 1.14A 4lv9A-5hx0A:
undetectable
4lv9B-5hx0A:
undetectable		 4lv9A-5hx0A:
23.30
4lv9B-5hx0A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		4 / 7 ASP A 293
SER A 291
ALA A 250
SER A 249
 None
 1.16A 4lv9A-5hx0A:
undetectable
4lv9B-5hx0A:
undetectable		 4lv9A-5hx0A:
23.30
4lv9B-5hx0A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		5 / 11 ASP A 123
VAL A  89
ASP A  90
GLY A 166
GLY A 120
 ACT  A 402 (-2.9A)
None
None
None
None
 1.20A 4xp4A-5hx0A:
undetectable		 4xp4A-5hx0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		5 / 12 ASN A 261
GLY A 308
ALA A 286
TYR A 365
GLU A 262
 PG4  A 401 ( 4.3A)
None
None
ACT  A 402 (-4.5A)
ACT  A 402 ( 4.6A)
 1.23A 4xt8A-5hx0A:
undetectable		 4xt8A-5hx0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		5 / 11 VAL A 376
VAL A 378
ILE A  36
ILE A 352
LEU A 322
 None
 0.99A 5e4dB-5hx0A:
undetectable		 5e4dB-5hx0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		4 / 5 SER A 259
VAL A 258
GLY A 281
ALA A 280
 None
 1.07A 5k50A-5hx0A:
undetectable		 5k50A-5hx0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		4 / 5 VAL A 353
PRO A 331
GLY A 333
TYR A 327
 None
 1.34A 5x80A-5hx0A:
undetectable
5x80B-5hx0A:
undetectable		 5x80A-5hx0A:
18.42
5x80B-5hx0A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5hx0 UNCHARACTERIZED
PROTEIN DFER_1899
(Dyadobacter
fermentans) 		5 / 10 ILE A  36
VAL A 378
ALA A 368
LEU A 396
LEU A 354
 None
 0.87A 6f6nA-5hx0A:
undetectable
6f6nB-5hx0A:
undetectable		 6f6nA-5hx0A:
12.41
6f6nB-5hx0A:
13.07