SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hx6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 122
ILE A 152
ILE A 252
ALA A 223
ASN A 224
 None
 1.20A 1jtxA-5hx6A:
undetectable		 1jtxA-5hx6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		3 / 3 HIS A  36
MET A  42
MET A  12
 None
 1.13A 2vj1A-5hx6A:
undetectable		 2vj1A-5hx6A:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		5 / 12 VAL A  76
HIS A 136
LEU A 145
ALA A 155
ASP A 156
 65U  A 301 (-4.7A)
65U  A 301 (-3.3A)
None
65U  A 301 ( 3.9A)
65U  A 301 (-4.7A)
 0.68A 3ik3A-5hx6A:
26.1		 3ik3A-5hx6A:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		5 / 12 VAL A  76
HIS A 136
LEU A 145
ALA A 155
ASP A 156
 65U  A 301 (-4.7A)
65U  A 301 (-3.3A)
None
65U  A 301 ( 3.9A)
65U  A 301 (-4.7A)
 0.70A 3ik3B-5hx6A:
21.6		 3ik3B-5hx6A:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 216
TYR A 228
ILE A 144
TYR A 192
GLU A 226
 None
 1.43A 3q5pA-5hx6A:
undetectable		 3q5pA-5hx6A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		5 / 10 ALA A 160
ASP A 156
SER A 209
SER A 213
ILE A 135
 None
65U  A 301 (-4.7A)
None
None
None
 1.12A 3qgtA-5hx6A:
undetectable		 3qgtA-5hx6A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		4 / 5 LEU A 293
GLY A 116
PHE A 285
PHE A 288
 None
 1.21A 3smtA-5hx6A:
undetectable		 3smtA-5hx6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		5 / 8 VAL A  75
VAL A  76
LEU A 145
ILE A 154
ASP A 156
 65U  A 301 ( 4.3A)
65U  A 301 (-4.7A)
None
65U  A 301 (-4.1A)
65U  A 301 (-4.7A)
 0.62A 3wzeA-5hx6A:
22.5		 3wzeA-5hx6A:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		5 / 12 SER A  73
PHE A 278
ARG A  74
ILE A 123
HIS A 136
 None
None
None
None
65U  A 301 (-3.3A)
 1.46A 4c49C-5hx6A:
undetectable		 4c49C-5hx6A:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		4 / 5 ILE A 154
TYR A  94
MET A  95
ILE A 144
 65U  A 301 (-4.1A)
None
None
None
 0.88A 4c8bA-5hx6A:
26.7		 4c8bA-5hx6A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		3 / 3 TYR A  94
MET A  95
ILE A 144
 None
 0.80A 4c8bB-5hx6A:
23.2		 4c8bB-5hx6A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		3 / 3 TYR A  94
MET A  95
ILE A 154
 None
None
65U  A 301 (-4.1A)
 0.32A 4c8bB-5hx6A:
23.2		 4c8bB-5hx6A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 129
HIS A 136
LEU A 145
ALA A 155
ASP A 156
 65U  A 301 ( 4.6A)
65U  A 301 (-3.3A)
None
65U  A 301 ( 3.9A)
65U  A 301 (-4.7A)
 0.54A 4uxqA-5hx6A:
25.7		 4uxqA-5hx6A:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		6 / 11 LYS A  45
MET A  95
GLY A  98
ASN A 143
LEU A 145
ALA A 155
 65U  A 301 (-3.4A)
None
None
None
None
65U  A 301 ( 3.9A)
 0.72A 4wa9A-5hx6A:
24.7		 4wa9A-5hx6A:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens) 		5 / 12 VAL A  76
HIS A 136
LEU A 145
ALA A 155
ASP A 156
 65U  A 301 (-4.7A)
65U  A 301 (-3.3A)
None
65U  A 301 ( 3.9A)
65U  A 301 (-4.7A)
 0.59A 5mo4A-5hx6A:
22.4		 5mo4A-5hx6A:
23.20