SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hxa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		4 / 7 VAL A  19
LEU A  40
VAL A  36
LEU A 125
 None
 0.83A 1cqpA-5hxaA:
4.2
1cqpB-5hxaA:
2.3		 1cqpA-5hxaA:
17.43
1cqpB-5hxaA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		4 / 5 ARG A 150
ALA A 146
ASP A 189
GLY A 159
 None
 1.19A 1e7bA-5hxaA:
undetectable		 1e7bA-5hxaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 9 LEU A 302
VAL A 363
GLY A 364
ALA A 425
LEU A 426
 None
 0.99A 1e7bA-5hxaA:
undetectable		 1e7bA-5hxaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 11 PHE A  88
TYR A 111
TYR A 114
LEU A 172
HIS A 178
 None
 1.49A 1e7wB-5hxaA:
6.1		 1e7wB-5hxaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		4 / 6 HIS A 437
LEU A 392
LEU A 404
PRO A 405
 None
 1.19A 1hz4A-5hxaA:
undetectable		 1hz4A-5hxaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 278
GLU A 281
LEU A 273
ILE A 319
HIS A  98
 None
 1.21A 1kyvA-5hxaA:
4.3
1kyvE-5hxaA:
4.3		 1kyvA-5hxaA:
15.51
1kyvE-5hxaA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 12 HIS A  98
GLY A 278
GLU A 281
LEU A 273
ILE A 319
 None
 1.22A 1kyvB-5hxaA:
4.3
1kyvC-5hxaA:
2.3		 1kyvB-5hxaA:
15.51
1kyvC-5hxaA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 12 HIS A  98
GLY A 278
GLU A 281
LEU A 273
ILE A 319
 None
 1.26A 1kyvC-5hxaA:
2.3
1kyvD-5hxaA:
4.4		 1kyvC-5hxaA:
15.51
1kyvD-5hxaA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 12 HIS A  98
GLY A 278
GLU A 281
LEU A 273
ILE A 319
 None
 1.27A 1kyvD-5hxaA:
4.4
1kyvE-5hxaA:
4.3		 1kyvD-5hxaA:
15.51
1kyvE-5hxaA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		4 / 4 GLY A 192
VAL A 229
TRP A 136
GLY A 159
 None
 1.28A 1ng8A-5hxaA:
undetectable		 1ng8A-5hxaA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		4 / 4 GLY A 192
VAL A 229
TRP A 136
GLY A 159
 None
 1.28A 1ng8B-5hxaA:
undetectable		 1ng8B-5hxaA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 10 ALA A 306
ARG A 272
LEU A 273
LEU A 279
LEU A 354
 None
 1.14A 2bxqA-5hxaA:
undetectable		 2bxqA-5hxaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 460
ILE A 135
LEU A 125
ILE A 134
VAL A  36
 None
 1.13A 2ygpA-5hxaA:
undetectable		 2ygpA-5hxaA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 9 GLY A 399
ALA A 400
MET A 444
GLY A 235
ILE A 234
 None
 0.98A 3ogpA-5hxaA:
undetectable		 3ogpA-5hxaA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 369
GLU A 281
LEU A 279
LEU A 273
LEU A 103
 None
 1.21A 4j24D-5hxaA:
undetectable		 4j24D-5hxaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		3 / 3 SER A  89
TYR A 114
PRO A  95
 None
 0.76A 4k8cA-5hxaA:
5.2		 4k8cA-5hxaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		3 / 3 SER A  89
TYR A 114
PRO A  95
 None
 0.74A 4kahA-5hxaA:
4.3		 4kahA-5hxaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		3 / 3 SER A  89
TYR A 114
PRO A  95
 None
 0.74A 4kahB-5hxaA:
3.9		 4kahB-5hxaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		3 / 3 SER A  89
TYR A 114
PRO A  95
 None
 0.77A 4kanA-5hxaA:
4.3		 4kanA-5hxaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		3 / 3 SER A  89
TYR A 114
PRO A  95
 None
 0.76A 4kanB-5hxaA:
3.9		 4kanB-5hxaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		3 / 3 SER A  89
TYR A 114
PRO A  95
 None
 0.75A 4kbeA-5hxaA:
5.4		 4kbeA-5hxaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		3 / 3 SER A  89
TYR A 114
PRO A  95
 None
 0.75A 4kbeB-5hxaA:
5.4		 4kbeB-5hxaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		3 / 3 SER A 276
TYR A 275
PRO A 165
 None
 0.97A 4kbeB-5hxaA:
5.4		 4kbeB-5hxaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		3 / 3 SER A  89
TYR A 114
PRO A  95
 None
 0.74A 4lbgA-5hxaA:
4.8		 4lbgA-5hxaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		3 / 3 SER A  89
TYR A 114
PRO A  95
 None
 0.74A 4lbgB-5hxaA:
4.8		 4lbgB-5hxaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 12 VAL A 154
LEU A 152
ARG A 150
LEU A 125
ALA A 146
 None
 1.00A 4o1zB-5hxaA:
undetectable		 4o1zB-5hxaA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		4 / 5 VAL A 117
VAL A  74
TYR A  81
ARG A 150
 None
 1.10A 4r7iA-5hxaA:
undetectable		 4r7iA-5hxaA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		4 / 5 ILE A 164
SER A  89
HIS A 141
ASP A 274
 None
 1.35A 4rzvB-5hxaA:
undetectable		 4rzvB-5hxaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		4 / 8 LEU A 302
LEU A 279
THR A 367
GLN A 417
 None
 0.82A 5hbsA-5hxaA:
undetectable		 5hbsA-5hxaA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 12 PHE A 456
GLY A 235
GLN A 194
VAL A 451
LEU A 449
 None
 1.16A 5kocB-5hxaA:
2.3		 5kocB-5hxaA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		4 / 8 LEU A 302
LEU A 279
THR A 367
GLN A 417
 None
 0.81A 5ljbA-5hxaA:
undetectable		 5ljbA-5hxaA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		4 / 7 PHE A 286
ARG A 333
ILE A 330
GLY A 332
 None
EDO  A 506 ( 3.1A)
None
None
 0.96A 5nzyA-5hxaA:
undetectable		 5nzyA-5hxaA:
21.03