SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5hxd PROTEIN MPAA
(Escherichia
coli) 		3 / 3 ASN A 100
TRP A 106
GLN A 139
 None
 1.43A 1xoqA-5hxdA:
undetectable		 1xoqA-5hxdA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5hxd PROTEIN MPAA
(Escherichia
coli) 		4 / 7 GLU A  18
ALA A  37
PRO A  33
ALA A  34
 None
 1.04A 2ejfA-5hxdA:
undetectable		 2ejfA-5hxdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5hxd PROTEIN MPAA
(Escherichia
coli) 		4 / 7 GLU A  18
ALA A  37
PRO A  33
ALA A  34
 None
 1.08A 2zgwA-5hxdA:
undetectable		 2zgwA-5hxdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5hxd PROTEIN MPAA
(Escherichia
coli) 		4 / 6 GLU A  18
ALA A  37
PRO A  33
ALA A  34
 None
 1.04A 2zgwB-5hxdA:
undetectable		 2zgwB-5hxdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 5hxd PROTEIN MPAA
(Escherichia
coli) 		4 / 5 VAL A   3
LEU A  70
LEU A  66
ASN A 229
 None
 0.97A 4a9jA-5hxdA:
undetectable		 4a9jA-5hxdA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 5hxd PROTEIN MPAA
(Escherichia
coli) 		4 / 6 GLY A  83
PRO A  81
ASN A  80
GLY A  26
 None
 0.91A 4fjpA-5hxdA:
undetectable		 4fjpA-5hxdA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5hxd PROTEIN MPAA
(Escherichia
coli) 		5 / 12 ILE A 163
ILE A 145
LEU A 141
GLY A 196
ASN A  98
 None
None
None
None
CAC  A 302 (-3.3A)
 1.15A 4o1eB-5hxdA:
undetectable		 4o1eB-5hxdA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 5hxd PROTEIN MPAA
(Escherichia
coli) 		5 / 12 ALA A  62
LEU A 231
LEU A 230
LEU A  77
PRO A  14
 None
 1.16A 4xi3D-5hxdA:
undetectable		 4xi3D-5hxdA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 5hxd PROTEIN MPAA
(Escherichia
coli) 		5 / 12 PHE A 179
LEU A 231
PHE A 211
ALA A  46
LEU A  77
 None
 1.23A 5iepA-5hxdA:
undetectable		 5iepA-5hxdA:
16.46