SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AEG_A_4APA296_1 (CYTOCHROME C PEROXIDASE)	5hxf	3C PROTEASE (Enterovirus A)	4 / 8	GLY A 160 THR A 153 GLY A 150 LEU A 11	None	0.78A	1aegA-5hxfA: undetectable	1aegA-5hxfA: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CR4_X_PNTX101_0 (PROTEIN S100-B)	5hxf	3C PROTEASE (Enterovirus A)	3 / 3	CYH A 172 HIS A 162 PHE A 171	None AG7 A 201 (-4.0A) AG7 A 201 (-4.1A)	1.14A	3cr4X-5hxfA: undetectable	3cr4X-5hxfA: 16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGK_A_0TXA302_0 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	5hxf	3C PROTEASE (Enterovirus A)	4 / 6	PHE A 90 ILE A 91 PRO A 92 PHE A 7	None	1.10A	4fgkA-5hxfA: undetectable	4fgkA-5hxfA: 22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R82_A_ACTA207_0 (OXIDOREDUCTASE)	5hxf	3C PROTEASE (Enterovirus A)	4 / 4	GLU A 66 GLY A 68 HIS A 134 ARG A 135	None	1.08A	4r82A-5hxfA: 2.7 4r82B-5hxfA: 2.8	4r82A-5hxfA: 21.13 4r82B-5hxfA: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRW_A_LURA705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5hxf	3C PROTEASE (Enterovirus A)	5 / 12	VAL A 158 LEU A 175 VAL A 31 GLY A 30 LEU A 11	None	1.18A	4rrwA-5hxfA: undetectable	4rrwA-5hxfA: 15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRW_B_LURB705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5hxf	3C PROTEASE (Enterovirus A)	5 / 12	VAL A 158 LEU A 175 VAL A 31 GLY A 30 LEU A 11	None	1.17A	4rrwB-5hxfA: undetectable	4rrwB-5hxfA: 15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRZ_A_LURA705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5hxf	3C PROTEASE (Enterovirus A)	5 / 12	VAL A 158 LEU A 175 VAL A 31 GLY A 30 LEU A 11	None	1.18A	4rrzA-5hxfA: undetectable	4rrzA-5hxfA: 15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRZ_B_LURB705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5hxf	3C PROTEASE (Enterovirus A)	5 / 12	VAL A 158 LEU A 175 VAL A 31 GLY A 30 LEU A 11	None	1.17A	4rrzB-5hxfA: undetectable	4rrzB-5hxfA: 15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L1F_D_6ZPD902_1 (GLUTAMATE RECEPTOR 2)	5hxf	3C PROTEASE (Enterovirus A)	5 / 10	PHE A 84 ASP A 86 PHE A 90 SER A 10 ASN A 15	None	1.48A	5l1fD-5hxfA: undetectable	5l1fD-5hxfA: 14.84

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AEG_A_4APA296_1","CYTOCHROME C PEROXIDASE","5hxf","3C PROTEASE","Enterovirus A",4,"GLY A 160;THR A 153;GLY A 150;LEU A  11","None","0.78A","1aegA-5hxfA:undetectable","1aegA-5hxfA:19.21"],["3CR4_X_PNTX101_0","PROTEIN S100-B","5hxf","3C PROTEASE","Enterovirus A",3,"CYH A 172;HIS A 162;PHE A 171","None;AG7 A 201 (-4.0A);AG7 A 201 (-4.1A)","1.14A","3cr4X-5hxfA:undetectable","3cr4X-5hxfA:16.76"],["4FGK_A_0TXA302_0","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","5hxf","3C PROTEASE","Enterovirus A",4,"PHE A  90;ILE A  91;PRO A  92;PHE A   7","None","1.10A","4fgkA-5hxfA:undetectable","4fgkA-5hxfA:22.05"],["4R82_A_ACTA207_0","OXIDOREDUCTASE","5hxf","3C PROTEASE","Enterovirus A",4,"GLU A  66;GLY A  68;HIS A 134;ARG A 135","None","1.08A","4r82A-5hxfA:2.7;4r82B-5hxfA:2.8","4r82A-5hxfA:21.13;4r82B-5hxfA:21.13"],["4RRW_A_LURA705_1","PROSTAGLANDIN G\/H SYNTHASE 2","5hxf","3C PROTEASE","Enterovirus A",5,"VAL A 158;LEU A 175;VAL A  31;GLY A  30;LEU A  11","None","1.18A","4rrwA-5hxfA:undetectable","4rrwA-5hxfA:15.14"],["4RRW_B_LURB705_1","PROSTAGLANDIN G\/H SYNTHASE 2","5hxf","3C PROTEASE","Enterovirus A",5,"VAL A 158;LEU A 175;VAL A  31;GLY A  30;LEU A  11","None","1.17A","4rrwB-5hxfA:undetectable","4rrwB-5hxfA:15.14"],["4RRZ_A_LURA705_1","PROSTAGLANDIN G\/H SYNTHASE 2","5hxf","3C PROTEASE","Enterovirus A",5,"VAL A 158;LEU A 175;VAL A  31;GLY A  30;LEU A  11","None","1.18A","4rrzA-5hxfA:undetectable","4rrzA-5hxfA:15.14"],["4RRZ_B_LURB705_1","PROSTAGLANDIN G\/H SYNTHASE 2","5hxf","3C PROTEASE","Enterovirus A",5,"VAL A 158;LEU A 175;VAL A  31;GLY A  30;LEU A  11","None","1.17A","4rrzB-5hxfA:undetectable","4rrzB-5hxfA:15.14"],["5L1F_D_6ZPD902_1","GLUTAMATE RECEPTOR 2","5hxf","3C PROTEASE","Enterovirus A",5,"PHE A  84;ASP A  86;PHE A  90;SER A  10;ASN A  15","None","1.48A","5l1fD-5hxfA:undetectable","5l1fD-5hxfA:14.84"]]