SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hxk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		5 / 12 PHE A  98
LEU A  11
VAL A  13
ALA A 349
ALA A 185
 PHE  A  98 ( 1.3A)
LEU  A  11 ( 0.5A)
VAL  A  13 ( 0.6A)
ALA  A 349 ( 0.0A)
ALA  A 185 ( 0.0A)
 1.28A 1q23A-5hxkA:
undetectable
1q23B-5hxkA:
undetectable		 1q23A-5hxkA:
18.01
1q23B-5hxkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 129
LEU A 126
LEU A 123
ALA A 122
LEU A  46
 LEU  A 129 ( 0.5A)
LEU  A 126 ( 0.6A)
LEU  A 123 ( 0.6A)
ALA  A 122 ( 0.0A)
LEU  A  46 ( 0.6A)
 1.00A 1s9pC-5hxkA:
undetectable		 1s9pC-5hxkA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		4 / 4 LEU A 104
SER A  76
LEU A  67
LEU A  63
 LEU  A 104 ( 0.6A)
SER  A  76 ( 0.0A)
LEU  A  67 ( 0.5A)
LEU  A  63 ( 0.5A)
 1.14A 1yajA-5hxkA:
undetectable		 1yajA-5hxkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		4 / 5 LEU A 104
SER A  76
LEU A  67
LEU A  63
 LEU  A 104 ( 0.6A)
SER  A  76 ( 0.0A)
LEU  A  67 ( 0.5A)
LEU  A  63 ( 0.5A)
 1.16A 1yajD-5hxkA:
undetectable		 1yajD-5hxkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		3 / 3 GLY A 242
GLY A 286
GLY A 291
 GLY  A 242 ( 0.0A)
GLY  A 286 ( 0.0A)
GLY  A 291 ( 0.0A)
 0.42A 3bogC-5hxkA:
undetectable		 3bogC-5hxkA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		5 / 11 GLY A 188
ALA A 353
VAL A 186
PRO A  91
PHE A  89
 GLY  A 188 ( 0.0A)
ALA  A 353 ( 0.0A)
VAL  A 186 ( 0.6A)
PRO  A  91 ( 1.1A)
PHE  A  89 ( 1.3A)
 1.48A 4j4vA-5hxkA:
undetectable		 4j4vA-5hxkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 188
ALA A 353
VAL A 186
PRO A  91
PHE A  89
 GLY  A 188 ( 0.0A)
ALA  A 353 ( 0.0A)
VAL  A 186 ( 0.6A)
PRO  A  91 ( 1.1A)
PHE  A  89 ( 1.3A)
 1.44A 4j4vB-5hxkA:
0.7		 4j4vB-5hxkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 188
ALA A 353
VAL A 186
PRO A  91
PHE A  89
 GLY  A 188 ( 0.0A)
ALA  A 353 ( 0.0A)
VAL  A 186 ( 0.6A)
PRO  A  91 ( 1.1A)
PHE  A  89 ( 1.3A)
 1.47A 4j4vA-5hxkA:
undetectable
4j4vE-5hxkA:
0.0		 4j4vA-5hxkA:
22.25
4j4vE-5hxkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUF_A_ACTA605_0
(SERUM ALBUMIN)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		4 / 4 ALA A 251
HIS A 387
PHE A 383
LEU A 318
 ALA  A 251 ( 0.0A)
HIS  A 387 ( 1.0A)
PHE  A 383 ( 1.3A)
LEU  A 318 ( 0.6A)
 1.34A 4lufA-5hxkA:
0.0		 4lufA-5hxkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		4 / 4 ALA A 251
HIS A 387
PHE A 383
LEU A 318
 ALA  A 251 ( 0.0A)
HIS  A 387 ( 1.0A)
PHE  A 383 ( 1.3A)
LEU  A 318 ( 0.6A)
 1.36A 4luhA-5hxkA:
0.4		 4luhA-5hxkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		4 / 8 LEU A 138
GLU A 153
LEU A 129
LEU A 397
 LEU  A 138 ( 0.6A)
GLU  A 153 ( 0.6A)
LEU  A 129 ( 0.5A)
LEU  A 397 ( 0.6A)
 1.25A 5dxeA-5hxkA:
undetectable		 5dxeA-5hxkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		5 / 12 ALA A  45
ALA A 122
LEU A 123
ALA A  33
GLY A  42
 ALA  A  45 ( 0.0A)
ALA  A 122 ( 0.0A)
LEU  A 123 ( 0.6A)
ALA  A  33 ( 0.0A)
GLY  A  42 ( 0.0A)
 1.30A 5jglB-5hxkA:
undetectable		 5jglB-5hxkA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		5 / 10 ARG A 175
GLY A  39
LEU A  46
LEU A 169
ALA A 164
 ARG  A 175 ( 0.6A)
GLY  A  39 ( 0.0A)
LEU  A  46 ( 0.6A)
LEU  A 169 ( 0.6A)
ALA  A 164 ( 0.0A)
 1.07A 5o96G-5hxkA:
undetectable
5o96H-5hxkA:
undetectable		 5o96G-5hxkA:
21.39
5o96H-5hxkA:
21.39