SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hxs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A 119
GLY A 242
LEU A 245
GLY A 128
 SR  A 402 ( 4.6A)
None
None
None
 0.77A 1d0vA-5hxsA:
undetectable		 1d0vA-5hxsA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A 119
GLY A 242
LEU A 245
GLY A 128
 SR  A 402 ( 4.6A)
None
None
None
 0.76A 1jhaA-5hxsA:
undetectable		 1jhaA-5hxsA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  30
ALA A 220
VAL A  36
SER A  37
ALA A  43
 MYS  A 405 ( 4.8A)
None
None
None
None
 1.16A 1sg9C-5hxsA:
undetectable		 1sg9C-5hxsA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		4 / 8 PHE A 207
LEU A  88
VAL A  85
LEU A  84
 MYS  A 403 (-4.2A)
None
None
None
 0.74A 2w98B-5hxsA:
undetectable		 2w98B-5hxsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A  43
ALA A  47
THR A  50
PHE A  23
 None
 0.92A 2xfhA-5hxsA:
undetectable		 2xfhA-5hxsA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A  47
TYR A 138
ILE A 238
TYR A 108
 None
 0.99A 2zm8A-5hxsA:
undetectable		 2zm8A-5hxsA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A  47
TYR A 138
ILE A 238
TYR A 108
 None
 0.97A 2zmaA-5hxsA:
undetectable		 2zmaA-5hxsA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  13
GLY A  12
ASP A 184
LEU A  16
LEU A 211
 None
 1.03A 3cjtC-5hxsA:
undetectable		 3cjtC-5hxsA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 239
ILE A  55
ASP A 240
LEU A 254
PRO A 255
 None
None
SR  A 401 ( 4.7A)
None
None
 1.22A 3cl9A-5hxsA:
undetectable		 3cl9A-5hxsA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		4 / 5 PRO A 212
SER A  51
LEU A 218
SER A 217
 None
SR  A 401 ( 4.2A)
TOE  A 410 (-4.1A)
None
 1.41A 3iluH-5hxsA:
undetectable		 3iluH-5hxsA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 230
ILE A 105
LEU A 271
ASP A 240
SER A  51
 None
None
None
SR  A 401 ( 4.7A)
SR  A 401 ( 4.2A)
 1.09A 3ko0A-5hxsA:
undetectable
3ko0B-5hxsA:
undetectable
3ko0C-5hxsA:
undetectable
3ko0D-5hxsA:
undetectable		 3ko0A-5hxsA:
12.62
3ko0B-5hxsA:
12.62
3ko0C-5hxsA:
12.62
3ko0D-5hxsA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 240
SER A  51
LEU A 230
ILE A 105
LEU A 271
 SR  A 401 ( 4.7A)
SR  A 401 ( 4.2A)
None
None
None
 1.06A 3ko0G-5hxsA:
0.4
3ko0H-5hxsA:
undetectable
3ko0I-5hxsA:
undetectable
3ko0J-5hxsA:
undetectable		 3ko0G-5hxsA:
12.62
3ko0H-5hxsA:
12.62
3ko0I-5hxsA:
12.62
3ko0J-5hxsA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A 240
SER A  51
LEU A 271
LEU A 230
ILE A 105
 SR  A 401 ( 4.7A)
SR  A 401 ( 4.2A)
None
None
None
 1.10A 3ko0A-5hxsA:
0.2
3ko0B-5hxsA:
undetectable
3ko0I-5hxsA:
undetectable
3ko0J-5hxsA:
undetectable		 3ko0A-5hxsA:
12.62
3ko0B-5hxsA:
12.62
3ko0I-5hxsA:
12.62
3ko0J-5hxsA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 230
ILE A 105
LEU A 271
ASP A 240
SER A  51
 None
None
None
SR  A 401 ( 4.7A)
SR  A 401 ( 4.2A)
 1.17A 3ko0K-5hxsA:
undetectable
3ko0L-5hxsA:
undetectable
3ko0S-5hxsA:
undetectable
3ko0T-5hxsA:
undetectable		 3ko0K-5hxsA:
12.62
3ko0L-5hxsA:
12.62
3ko0S-5hxsA:
12.62
3ko0T-5hxsA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 271
LEU A 230
ILE A 105
ASP A 240
SER A  51
 None
None
None
SR  A 401 ( 4.7A)
SR  A 401 ( 4.2A)
 1.12A 3ko0K-5hxsA:
undetectable
3ko0L-5hxsA:
undetectable
3ko0M-5hxsA:
undetectable
3ko0N-5hxsA:
undetectable		 3ko0K-5hxsA:
12.62
3ko0L-5hxsA:
12.62
3ko0M-5hxsA:
12.62
3ko0N-5hxsA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 230
ILE A 105
LEU A 271
ASP A 240
SER A  51
 None
None
None
SR  A 401 ( 4.7A)
SR  A 401 ( 4.2A)
 1.04A 3ko0M-5hxsA:
undetectable
3ko0N-5hxsA:
undetectable
3ko0O-5hxsA:
undetectable
3ko0P-5hxsA:
undetectable		 3ko0M-5hxsA:
12.62
3ko0N-5hxsA:
12.62
3ko0O-5hxsA:
12.62
3ko0P-5hxsA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 254
ALA A 244
GLY A 248
SER A 249
ALA A 239
 None
 1.12A 3ou6A-5hxsA:
undetectable		 3ou6A-5hxsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 254
ALA A 244
GLY A 248
SER A 249
ALA A 239
 None
 1.10A 3ou6B-5hxsA:
undetectable		 3ou6B-5hxsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 254
ALA A 244
GLY A 248
SER A 249
ALA A 239
 None
 1.11A 3ou6C-5hxsA:
undetectable		 3ou6C-5hxsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 254
ALA A 244
GLY A 248
SER A 249
ALA A 239
 None
 1.13A 3ou7B-5hxsA:
undetectable		 3ou7B-5hxsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 254
ALA A 244
GLY A 248
SER A 249
ALA A 239
 None
 1.13A 3ou7C-5hxsA:
undetectable		 3ou7C-5hxsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A 257
ILE A 241
ASP A 240
GLY A  76
ILE A  75
 None
None
SR  A 401 ( 4.7A)
None
None
 1.48A 4djfA-5hxsA:
undetectable		 4djfA-5hxsA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A 257
ASN A 258
ILE A 241
LEU A 131
ILE A  75
 None
 1.18A 4o1eA-5hxsA:
undetectable		 4o1eA-5hxsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A 257
ASN A 258
ILE A 241
LEU A 131
ILE A  75
 None
 1.13A 4o1eB-5hxsA:
undetectable		 4o1eB-5hxsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A 269
LEU A 106
ILE A 238
ILE A 234
 None
 0.81A 4ojbA-5hxsA:
undetectable		 4ojbA-5hxsA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 11 ALA A 220
ALA A 219
GLY A 231
GLY A  42
SER A  27
 None
TOE  A 410 (-3.6A)
None
None
None
 1.11A 4qvwK-5hxsA:
undetectable
4qvwL-5hxsA:
undetectable		 4qvwK-5hxsA:
23.79
4qvwL-5hxsA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 9 MET A 267
ALA A 290
LEU A 289
GLY A 285
PHE A 182
 None
 1.39A 4y28A-5hxsA:
2.8
4y28J-5hxsA:
undetectable		 4y28A-5hxsA:
17.85
4y28J-5hxsA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  47
TRP A 141
TYR A 138
ALA A  43
GLY A 231
 None
 1.19A 5tzoA-5hxsA:
undetectable		 5tzoA-5hxsA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  87
LEU A  86
LEU A 269
ILE A 280
GLY A 281
 None
 0.95A 5vkqC-5hxsA:
undetectable
5vkqD-5hxsA:
undetectable		 5vkqC-5hxsA:
10.47
5vkqD-5hxsA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 5hxs SODIUM,CALCIUM
EXCHANGER
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 234
SER A 268
LEU A 139
ASP A 240
ILE A  82
 None
None
None
SR  A 401 ( 4.7A)
None
 1.29A 6dwnB-5hxsA:
undetectable		 6dwnB-5hxsA:
14.13