SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 5hxt (2Z,6Z)-FARNESYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC
(Solanum
habrochaites) 		5 / 12 GLY A 202
GLY A 203
ASN A 258
ALA A 210
LEU A 237
 None
 1.01A 1bx4A-5hxtA:
undetectable		 1bx4A-5hxtA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5hxt (2Z,6Z)-FARNESYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC
(Solanum
habrochaites) 		5 / 12 GLU A 133
ILE A 207
ASP A 206
GLY A 202
SER A 131
 None
None
None
None
IPR  A 403 (-2.9A)
 1.42A 1q8jA-5hxtA:
undetectable		 1q8jA-5hxtA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 5hxt (2Z,6Z)-FARNESYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC
(Solanum
habrochaites) 		4 / 4 GLY A 167
TYR A 201
GLY A 202
ASP A 206
 None
 1.09A 3kl3A-5hxtA:
2.6		 3kl3A-5hxtA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5hxt (2Z,6Z)-FARNESYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC
(Solanum
habrochaites) 		4 / 8 HIS A 194
LEU A 176
LEU A 199
SER A 164
 None
 1.01A 3lm8B-5hxtA:
undetectable
3lm8D-5hxtA:
undetectable		 3lm8B-5hxtA:
24.62
3lm8D-5hxtA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5hxt (2Z,6Z)-FARNESYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC
(Solanum
habrochaites) 		5 / 12 GLU A 133
ILE A 207
ASP A 206
GLY A 202
SER A 131
 None
None
None
None
IPR  A 403 (-2.9A)
 1.39A 4djfA-5hxtA:
undetectable		 4djfA-5hxtA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 5hxt (2Z,6Z)-FARNESYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC
(Solanum
habrochaites) 		4 / 5 SER A 239
LYS A 240
LEU A 260
ASP A 206
 None
 1.48A 4ifxA-5hxtA:
undetectable		 4ifxA-5hxtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5hxt (2Z,6Z)-FARNESYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC
(Solanum
habrochaites) 		4 / 5 ASN A 200
LEU A 199
SER A 131
LEU A 145
 None
None
IPR  A 403 (-2.9A)
None
 1.11A 4n09C-5hxtA:
undetectable		 4n09C-5hxtA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 5hxt (2Z,6Z)-FARNESYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC
(Solanum
habrochaites) 		4 / 4 ASN A 200
LEU A 199
SER A 131
LEU A 145
 None
None
IPR  A 403 (-2.9A)
None
 1.02A 5kb5A-5hxtA:
undetectable		 5kb5A-5hxtA:
20.61