SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 5hxy TYROSINE RECOMBINASE
XERA
(Thermoplasma
acidophilum) 		4 / 8 ARG A 247
PHE A 248
GLY A 244
GLY A 254
 PO4  A 302 (-3.0A)
None
None
None
 0.94A 2y6rB-5hxyA:
undetectable		 2y6rB-5hxyA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5hxy TYROSINE RECOMBINASE
XERA
(Thermoplasma
acidophilum) 		4 / 5 LEU A 240
GLN A 262
THR A 265
HIS A 279
 None
 1.27A 2zj0C-5hxyA:
undetectable		 2zj0C-5hxyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5hxy TYROSINE RECOMBINASE
XERA
(Thermoplasma
acidophilum) 		4 / 5 LEU A 240
GLN A 262
THR A 265
HIS A 279
 None
 1.29A 3ce6B-5hxyA:
undetectable		 3ce6B-5hxyA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5hxy TYROSINE RECOMBINASE
XERA
(Thermoplasma
acidophilum) 		4 / 5 LEU A 240
GLN A 262
THR A 265
HIS A 279
 None
 1.22A 3n58C-5hxyA:
undetectable		 3n58C-5hxyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hxy TYROSINE RECOMBINASE
XERA
(Thermoplasma
acidophilum) 		6 / 12 ILE A 126
ALA A 177
LEU A 182
THR A 133
ILE A 155
LEU A 143
 None
 1.46A 4x5iA-5hxyA:
undetectable		 4x5iA-5hxyA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hxy TYROSINE RECOMBINASE
XERA
(Thermoplasma
acidophilum) 		5 / 12 VAL A 226
LEU A 231
GLY A 221
ALA A 220
LEU A 216
 None
 1.13A 5jvzB-5hxyA:
undetectable		 5jvzB-5hxyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5hxy TYROSINE RECOMBINASE
XERA
(Thermoplasma
acidophilum) 		4 / 8 HIS A 233
LEU A 240
THR A 237
ALA A 236
 None
 0.90A 5tt3H-5hxyA:
undetectable		 5tt3H-5hxyA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5hxy TYROSINE RECOMBINASE
XERA
(Thermoplasma
acidophilum) 		3 / 3 ASP A 147
ASN A 156
ASP A 165
 None
 0.80A 5vopA-5hxyA:
undetectable		 5vopA-5hxyA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5hxy TYROSINE RECOMBINASE
XERA
(Thermoplasma
acidophilum) 		3 / 3 ASP A 147
ASN A 156
ASP A 165
 None
 0.83A 5vopB-5hxyA:
undetectable		 5vopB-5hxyA:
24.22