SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		4 / 6 VAL A  35
VAL A 241
ILE A  80
ARG A   8
 None
 1.05A 1iepA-5hxzA:
undetectable		 1iepA-5hxzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		3 / 3 VAL A 296
ALA A 363
HIS A 157
 None
 0.55A 1q23G-5hxzA:
undetectable		 1q23G-5hxzA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		3 / 3 VAL A 296
ALA A 363
HIS A 157
 None
 0.77A 1q23L-5hxzA:
undetectable		 1q23L-5hxzA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		5 / 12 HIS A 157
ILE A 150
GLY A 116
VAL A 141
ALA A 140
 None
 1.14A 1tlsB-5hxzA:
undetectable		 1tlsB-5hxzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		4 / 7 GLY A  84
SER A 349
SER A 347
ARG A  53
 MHA  A 403 (-3.2A)
MHA  A 403 ( 4.6A)
MHA  A 403 (-2.8A)
MHA  A 403 (-3.1A)
 1.09A 2c8aD-5hxzA:
undetectable		 2c8aD-5hxzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		3 / 3 PHE A  60
VAL A  38
TRP A  82
 None
 0.83A 2cc8A-5hxzA:
1.7		 2cc8A-5hxzA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		3 / 3 PHE A  60
VAL A  38
TRP A  82
 None
 0.82A 2ccbA-5hxzA:
2.2		 2ccbA-5hxzA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		4 / 8 HIS A 324
SER A 349
ARG A 220
ALA A 351
 None
MHA  A 403 ( 4.6A)
None
None
 1.28A 2rk8A-5hxzA:
undetectable		 2rk8A-5hxzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		3 / 3 PHE A  60
VAL A  38
TRP A  82
 None
 0.83A 2vx9A-5hxzA:
2.4		 2vx9A-5hxzA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		4 / 7 HIS A  93
LEU A  30
PHE A  97
VAL A 243
 None
 0.95A 3jwqC-5hxzA:
undetectable		 3jwqC-5hxzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		4 / 7 VAL A  35
VAL A 241
ILE A  80
ARG A   8
 None
 1.09A 3mssB-5hxzA:
undetectable		 3mssB-5hxzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		5 / 11 ILE A  90
THR A 339
ILE A 269
LEU A 298
VAL A 344
 None
 1.04A 3n0hA-5hxzA:
undetectable		 3n0hA-5hxzA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		5 / 12 ILE A  90
THR A 339
ILE A 269
LEU A 298
VAL A 344
 None
 1.06A 3s3vA-5hxzA:
undetectable		 3s3vA-5hxzA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		4 / 7 ALA A  94
ALA A  56
ALA A  18
LEU A  12
 None
 0.88A 4du2A-5hxzA:
undetectable		 4du2A-5hxzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		4 / 7 ALA A  94
ALA A  56
ALA A  18
LEU A  12
 None
 0.80A 4du2B-5hxzA:
undetectable		 4du2B-5hxzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		4 / 5 PHE A  97
PHE A 297
ILE A  39
GLY A  40
 None
 0.92A 4ejjC-5hxzA:
undetectable		 4ejjC-5hxzA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		5 / 12 HIS A 157
ILE A 150
GLY A 116
VAL A 141
ALA A 140
 None
 1.21A 4fqsA-5hxzA:
undetectable		 4fqsA-5hxzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		5 / 12 HIS A 157
ILE A 150
GLY A 116
VAL A 141
ALA A 140
 None
 1.21A 4fqsB-5hxzA:
undetectable		 4fqsB-5hxzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		4 / 8 ILE A 255
ILE A 150
LYS A 107
GLY A 250
 None
 0.96A 4hdlA-5hxzA:
undetectable		 4hdlA-5hxzA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		4 / 7 GLU A 207
SER A 224
ILE A 201
VAL A 159
 None
 1.07A 4tvtA-5hxzA:
undetectable		 4tvtA-5hxzA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		5 / 12 HIS A  13
PHE A 345
THR A  95
VAL A   7
PHE A  97
 None
 1.20A 5x6yA-5hxzA:
undetectable		 5x6yA-5hxzA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		3 / 3 HIS A 157
ASN A 245
LEU A 113
 None
 0.89A 6f7lB-5hxzA:
undetectable		 6f7lB-5hxzA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		6 / 12 ILE A 201
LEU A 123
LEU A 199
GLY A 195
ASN A 194
ILE A 134
 None
None
None
None
MHA  A 403 (-2.7A)
None
 1.42A 6qxsB-5hxzA:
undetectable		 6qxsB-5hxzA:
21.20