SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hy3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hy3 MRNA
ENDORIBONUCLEASE
LSOA
ANTITOXIN DMD
(Escherichia
coli;
Escherichia
virus
T4) 		5 / 10 THR B  33
ALA B  32
PHE A 239
ALA B  46
ILE B  48
 None
 1.26A 1claA-5hy3B:
undetectable		 1claA-5hy3B:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5hy3 MRNA
ENDORIBONUCLEASE
LSOA
(Escherichia
coli) 		3 / 3 SER A 112
GLU A 113
GLU A 109
 None
 0.69A 1eqbD-5hy3A:
undetectable		 1eqbD-5hy3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5hy3 MRNA
ENDORIBONUCLEASE
LSOA
(Escherichia
coli) 		3 / 3 SER A 112
GLU A 113
GLU A 109
 None
 0.69A 1eqbB-5hy3A:
undetectable		 1eqbB-5hy3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 5hy3 MRNA
ENDORIBONUCLEASE
LSOA
(Escherichia
coli) 		3 / 3 TYR A 298
TYR A 250
GLY A 266
 None
 0.73A 3eteB-5hy3A:
undetectable
3eteD-5hy3A:
undetectable
3eteF-5hy3A:
undetectable		 3eteB-5hy3A:
21.85
3eteD-5hy3A:
21.85
3eteF-5hy3A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5hy3 MRNA
ENDORIBONUCLEASE
LSOA
ANTITOXIN DMD
(Escherichia
coli;
Escherichia
virus
T4) 		5 / 12 ILE A 214
ASP A 213
SER A 163
ASN A 166
GLN B  30
 None
 1.31A 4djfA-5hy3A:
undetectable		 4djfA-5hy3A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5hy3 MRNA
ENDORIBONUCLEASE
LSOA
(Escherichia
coli) 		5 / 12 ILE A 118
ILE A 152
ALA A 144
ILE A 165
PHE A 154
 None
 1.21A 4rp8C-5hy3A:
undetectable		 4rp8C-5hy3A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5hy3 ANTITOXIN DMD
MRNA
ENDORIBONUCLEASE
LSOA
(Escherichia
coli;
Escherichia
virus
T4) 		5 / 12 THR B  34
VAL B  56
GLN B  35
GLU A 246
TYR A  94
 None
 1.40A 4s0vA-5hy3B:
undetectable		 4s0vA-5hy3B:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hy3 MRNA
ENDORIBONUCLEASE
LSOA
(Escherichia
coli) 		4 / 5 LEU A 253
TYR A 250
ILE A 329
GLY A 266
 None
 1.05A 6hd6A-5hy3A:
undetectable		 6hd6A-5hy3A:
13.01