SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hy4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		4 / 7 THR A 281
VAL A 353
GLY A 349
ILE A 364
 None
 0.79A 1gtnC-5hy4A:
undetectable
1gtnD-5hy4A:
undetectable		 1gtnC-5hy4A:
11.22
1gtnD-5hy4A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		4 / 6 ARG A 229
ILE A 237
ALA A 215
ALA A 153
 None
 0.94A 1w0gA-5hy4A:
undetectable		 1w0gA-5hy4A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		6 / 12 GLN A 113
LEU A 262
ALA A  18
LEU A 274
MET A  20
LEU A 264
 None
 1.17A 2c12C-5hy4A:
undetectable		 2c12C-5hy4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		5 / 11 GLN A 113
LEU A 262
ALA A  18
LEU A 274
LEU A 264
 None
 1.05A 2c12F-5hy4A:
undetectable		 2c12F-5hy4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		5 / 11 LEU A 262
ALA A  18
LEU A 274
MET A  20
LEU A 264
 None
 1.30A 2c12F-5hy4A:
undetectable		 2c12F-5hy4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		5 / 12 ALA A  69
LEU A  51
VAL A  94
ARG A  81
LEU A  88
 None
 1.02A 2qk8A-5hy4A:
undetectable		 2qk8A-5hy4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		5 / 12 ALA A  69
LEU A  51
VAL A  94
ARG A  81
LEU A  88
 None
 1.03A 3datA-5hy4A:
undetectable		 3datA-5hy4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		4 / 4 GLY A 349
VAL A 353
GLY A 289
THR A 292
 None
 0.81A 3ib2A-5hy4A:
undetectable		 3ib2A-5hy4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		4 / 5 PHE A 317
ALA A  95
THR A  93
LEU A 264
 None
 1.16A 3t3zC-5hy4A:
undetectable		 3t3zC-5hy4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		5 / 12 GLY A 318
LEU A 352
GLY A 349
ALA A 249
LEU A 173
 None
 1.16A 3vywC-5hy4A:
undetectable		 3vywC-5hy4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		5 / 12 GLY A 318
LEU A 352
GLY A 350
ALA A 249
LEU A 173
 None
 1.09A 3vywC-5hy4A:
undetectable		 3vywC-5hy4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		4 / 6 SER A 270
ARG A 387
GLY A 298
GLY A 277
 None
 0.99A 4koeA-5hy4A:
undetectable
4koeB-5hy4A:
undetectable
4koeC-5hy4A:
undetectable		 4koeA-5hy4A:
22.01
4koeB-5hy4A:
22.01
4koeC-5hy4A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		5 / 12 GLU A 288
ASP A 286
ILE A 356
GLN A 309
ILE A 294
 None
 1.38A 4uroB-5hy4A:
undetectable		 4uroB-5hy4A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		5 / 12 GLU A 288
ASP A 286
ILE A 356
GLN A 309
ILE A 294
 None
 1.34A 4uroC-5hy4A:
undetectable		 4uroC-5hy4A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		4 / 6 GLY A 298
GLY A 277
SER A 270
ARG A 387
 None
 0.91A 4z53A-5hy4A:
undetectable
4z53B-5hy4A:
undetectable		 4z53A-5hy4A:
19.67
4z53B-5hy4A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		4 / 7 ARG A 387
GLY A 298
GLY A 277
SER A 270
 None
 0.95A 4z53A-5hy4A:
undetectable
4z53B-5hy4A:
undetectable		 4z53A-5hy4A:
19.67
4z53B-5hy4A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		5 / 9 THR A 250
LEU A 224
GLY A 219
VAL A 261
VAL A 176
 None
 1.35A 5cp4A-5hy4A:
undetectable		 5cp4A-5hy4A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		4 / 5 THR A 296
ALA A 293
THR A 292
HIS A 278
 None
 1.01A 5ecmA-5hy4A:
undetectable		 5ecmA-5hy4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		5 / 10 LEU A  77
ALA A  18
SER A 272
THR A  93
LEU A 264
 None
 1.27A 5mm4B-5hy4A:
undetectable		 5mm4B-5hy4A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		5 / 9 ALA A 246
VAL A 220
ALA A 221
SER A 245
GLY A 225
 None
 1.26A 6bklA-5hy4A:
undetectable
6bklB-5hy4A:
undetectable
6bklC-5hy4A:
undetectable
6bklD-5hy4A:
undetectable		 6bklA-5hy4A:
5.13
6bklB-5hy4A:
5.13
6bklC-5hy4A:
5.13
6bklD-5hy4A:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 5hy4 RING-OPENING
AMIDOHYDROLASE
(Frankia
sp.
Eul1b) 		3 / 3 HIS A 172
ASN A 266
LEU A 128
 None
 0.84A 6f7lB-5hy4A:
undetectable		 6f7lB-5hy4A:
23.57