SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		5 / 12 LEU A 377
SER A 356
SER A 355
CYH A 233
HIS A 380
 None
 1.20A 1db1A-5hy5A:
undetectable		 1db1A-5hy5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		5 / 12 LEU A 377
SER A 356
SER A 355
CYH A 233
HIS A 380
 None
 1.20A 1ie9A-5hy5A:
undetectable		 1ie9A-5hy5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		5 / 11 GLY A 299
HIS A 177
GLU A  50
GLY A  49
ILE A  56
 None
None
None
FAD  A 601 (-3.3A)
None
 1.14A 1jzsA-5hy5A:
0.6		 1jzsA-5hy5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		5 / 12 ILE A 352
LEU A  25
GLY A 353
THR A  21
LEU A 377
 None
None
FAD  A 601 ( 3.8A)
None
None
 1.03A 1liiA-5hy5A:
3.4		 1liiA-5hy5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 6 LEU A 256
LEU A 414
GLY A 415
ILE A 468
 None
 0.87A 1mt1G-5hy5A:
undetectable
1mt1J-5hy5A:
undetectable		 1mt1G-5hy5A:
8.67
1mt1J-5hy5A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		5 / 11 LEU A 477
GLY A 415
GLY A 473
TYR A 465
PRO A 462
 None
 1.05A 1p91A-5hy5A:
undetectable		 1p91A-5hy5A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 6 TYR A 394
SER A 356
ALA A 351
SER A 344
 None
 0.99A 1yvpB-5hy5A:
undetectable		 1yvpB-5hy5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 7 ALA A 175
TYR A 176
ARG A  57
TYR A  24
 None
 1.10A 2ajvH-5hy5A:
undetectable
2ajvL-5hy5A:
undetectable		 2ajvH-5hy5A:
18.09
2ajvL-5hy5A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 7 TYR A 394
SER A 356
ALA A 351
SER A 344
 None
 1.02A 2i91A-5hy5A:
2.1		 2i91A-5hy5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 7 TYR A 394
SER A 356
ALA A 351
SER A 344
 None
 1.02A 2i91B-5hy5A:
undetectable		 2i91B-5hy5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		5 / 12 ALA A  17
ALA A 184
GLY A 366
GLY A 353
TYR A 176
 FAD  A 601 (-3.6A)
None
FAD  A 601 ( 3.4A)
FAD  A 601 ( 3.8A)
None
 1.12A 2igtB-5hy5A:
2.7		 2igtB-5hy5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		3 / 3 ALA A 305
VAL A 303
TRP A 288
 None
 0.97A 2izqA-5hy5A:
undetectable
2izqB-5hy5A:
undetectable		 2izqA-5hy5A:
3.14
2izqB-5hy5A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 6 VAL A  48
PHE A 178
THR A 279
TRP A 290
 FAD  A 601 (-4.6A)
None
None
None
 1.35A 2q6oB-5hy5A:
2.7		 2q6oB-5hy5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 7 GLY A  18
PHE A  59
ILE A 367
PHE A  60
 None
None
FAD  A 601 (-3.5A)
None
 1.01A 2qmzA-5hy5A:
3.0
2qmzB-5hy5A:
3.0		 2qmzA-5hy5A:
17.46
2qmzB-5hy5A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 5 LEU A 114
LYS A 444
GLN A 446
LEU A 477
 None
 1.09A 3h5gA-5hy5A:
undetectable
3h5gB-5hy5A:
undetectable		 3h5gA-5hy5A:
4.61
3h5gB-5hy5A:
4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 5 MET A 466
PHE A  94
PHE A 122
PHE A 127
 None
 1.44A 3ko0F-5hy5A:
0.0
3ko0G-5hy5A:
0.0		 3ko0F-5hy5A:
12.16
3ko0G-5hy5A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 7 GLU A  68
TYR A 176
TYR A  78
TYR A 515
 None
 1.36A 3ku9B-5hy5A:
8.2		 3ku9B-5hy5A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		5 / 12 GLY A 212
VAL A 206
GLY A 246
VAL A 247
ILE A 214
 None
 1.06A 3nu5B-5hy5A:
undetectable		 3nu5B-5hy5A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		5 / 12 LEU A 146
PHE A  98
THR A 279
ILE A 292
ILE A  56
 None
 1.25A 3sp9A-5hy5A:
undetectable		 3sp9A-5hy5A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		3 / 3 ASP A 307
ARG A 335
LYS A 306
 None
 1.01A 3wipG-5hy5A:
undetectable		 3wipG-5hy5A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		3 / 3 GLY A 189
SER A 188
TRP A  19
 None
 0.90A 4e7cD-5hy5A:
undetectable		 4e7cD-5hy5A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 6 TRP A  70
ARG A 140
TYR A 176
TYR A 174
 None
 1.22A 4f8yA-5hy5A:
2.4
4f8yB-5hy5A:
2.0		 4f8yA-5hy5A:
15.97
4f8yB-5hy5A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 7 ARG A 140
TYR A 176
TYR A 174
TRP A  70
 None
 1.09A 4f8yC-5hy5A:
2.0
4f8yD-5hy5A:
2.0		 4f8yC-5hy5A:
15.97
4f8yD-5hy5A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_D_VK3D202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 5 TRP A  70
ARG A 140
TYR A 176
TYR A 174
 None
 1.16A 4f8yC-5hy5A:
2.0
4f8yD-5hy5A:
2.0		 4f8yC-5hy5A:
15.97
4f8yD-5hy5A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		5 / 12 GLY A 296
ILE A 298
GLN A 512
PHE A 516
ILE A 275
 None
 1.17A 4fglA-5hy5A:
2.8
4fglB-5hy5A:
2.9		 4fglA-5hy5A:
17.46
4fglB-5hy5A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		3 / 3 TYR A 304
GLN A 253
TRP A 288
 None
 1.17A 4kn2C-5hy5A:
undetectable		 4kn2C-5hy5A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		5 / 11 GLY A 296
ILE A 298
GLN A 512
PHE A 516
ILE A 275
 None
 1.12A 4qoiA-5hy5A:
2.8
4qoiB-5hy5A:
2.8		 4qoiA-5hy5A:
17.65
4qoiB-5hy5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 5 ALA A 502
ARG A 102
ALA A 130
GLU A  99
 None
 1.11A 5a06C-5hy5A:
4.9
5a06D-5hy5A:
undetectable		 5a06C-5hy5A:
21.54
5a06D-5hy5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		5 / 11 VAL A 350
SER A 344
PRO A 382
TYR A 394
LEU A 377
 None
 1.35A 5jh7B-5hy5A:
undetectable		 5jh7B-5hy5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		4 / 6 PHE A 408
SER A  54
HIS A  96
TYR A 463
 None
 1.38A 5ycnA-5hy5A:
undetectable		 5ycnA-5hy5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		3 / 3 LEU A 229
ASN A 395
LEU A 241
 None
 0.61A 6exiD-5hy5A:
4.0		 6exiD-5hy5A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 5hy5 TRYPTOPHAN
6-HALOGENASE
(Streptomyces
toxytricini) 		5 / 9 THR A  16
GLY A  15
GLY A  14
HIS A 198
VAL A 200
 FAD  A 601 (-3.8A)
FAD  A 601 (-3.3A)
FAD  A 601 (-3.5A)
None
None
 1.48A 6gnfA-5hy5A:
3.8		 6gnfA-5hy5A:
22.05