SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hy7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		6 / 12 HIS A 267
TYR A 265
LEU A 312
LEU A 215
LEU A 180
TYR A 217
 None
 1.42A 1fm6D-5hy7A:
undetectable		 1fm6D-5hy7A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A  19
GLN A 788
LEU A 427
GLY A 448
GLY A 370
 None
 1.11A 1httD-5hy7A:
undetectable		 1httD-5hy7A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 6 HIS A 803
ASP A 929
ASP A 928
PRO A 807
 None
 1.36A 1ilqA-5hy7A:
undetectable
1ilqC-5hy7A:
undetectable		 1ilqA-5hy7A:
5.60
1ilqC-5hy7A:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
YSF3
(Chaetomium
thermophilum) 		5 / 9 GLY A 847
PRO D  60
GLU A 315
ASP A 318
ARG A 280
 None
 1.14A 1mxdA-5hy7A:
undetectable		 1mxdA-5hy7A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
YSF3
(Chaetomium
thermophilum) 		5 / 11 GLY A 847
PRO D  60
GLU A 315
ASP A 318
ARG A 280
 None
 1.10A 1mxgA-5hy7A:
undetectable		 1mxgA-5hy7A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PHE A1213
VAL A 432
ILE A  15
VAL A1122
 None
 0.76A 1p2yA-5hy7A:
undetectable		 1p2yA-5hy7A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 11 SER A  62
LEU A  45
THR A  46
ILE A  68
THR A  89
 None
 1.10A 1pkvA-5hy7A:
undetectable
1pkvB-5hy7A:
undetectable		 1pkvA-5hy7A:
6.64
1pkvB-5hy7A:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 5 LEU A 973
HIS A 922
ILE A 902
PHE A 900
 None
 0.97A 1xf1A-5hy7A:
undetectable		 1xf1A-5hy7A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 659
ALA A 576
MET A 602
LEU A 644
CYH A 628
 None
 1.42A 1ya3A-5hy7A:
undetectable		 1ya3A-5hy7A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 659
ALA A 576
MET A 602
LEU A 644
CYH A 628
 None
 1.43A 1ya3B-5hy7A:
undetectable		 1ya3B-5hy7A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 4 GLY A 999
SER A 982
VAL A1008
LEU A 989
 None
 1.25A 1yajB-5hy7A:
undetectable		 1yajB-5hy7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 HIS A 267
TYR A 265
LEU A 312
LEU A 180
TYR A 217
 None
 1.47A 1zgyA-5hy7A:
undetectable		 1zgyA-5hy7A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 6 GLU A1176
ASP A1171
PHE A1091
ARG A1160
 None
 1.19A 2a3bB-5hy7A:
undetectable		 2a3bB-5hy7A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LEU A 609
ARG A 620
THR A 643
LEU A 644
 None
 0.95A 2dysN-5hy7A:
undetectable
2dysW-5hy7A:
undetectable		 2dysN-5hy7A:
18.40
2dysW-5hy7A:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 TYR A 733
GLN A  16
LEU A 782
PHE A1213
VAL A 742
 None
 1.40A 2g70B-5hy7A:
undetectable		 2g70B-5hy7A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		3 / 3 GLY A 118
ARG A 120
TYR A1162
 None
 0.85A 2opxA-5hy7A:
undetectable		 2opxA-5hy7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 HIS A 267
TYR A 265
VAL A 322
LEU A 215
TYR A 217
 None
 1.47A 2prgB-5hy7A:
undetectable		 2prgB-5hy7A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 7 TYR A  11
GLN A1110
ILE A1126
ASP A1133
 None
 1.14A 2xytI-5hy7A:
undetectable		 2xytI-5hy7A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 7 MET A1005
ASP A1023
VAL A1040
TYR A1007
 None
 1.00A 2yfbA-5hy7A:
undetectable		 2yfbA-5hy7A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LEU A 609
ARG A 620
THR A 643
LEU A 644
 None
 0.97A 3asoA-5hy7A:
undetectable
3asoJ-5hy7A:
undetectable		 3asoA-5hy7A:
18.40
3asoJ-5hy7A:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ASP A1133
ARG A1195
ILE A1207
SER A1211
 None
 1.39A 3ckzA-5hy7A:
undetectable		 3ckzA-5hy7A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		3 / 3 CYH A 447
PRO A 792
ASP A 422
 None
 0.92A 3hlwB-5hy7A:
undetectable		 3hlwB-5hy7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG A1208
ASP A  64
GLN A1119
 None
 0.82A 3lcvB-5hy7A:
undetectable		 3lcvB-5hy7A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 PHE A 948
GLY A 906
ALA A 920
THR A 939
ILE A 965
 None
 1.39A 3ld6A-5hy7A:
undetectable		 3ld6A-5hy7A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ARG A1145
LEU A1193
ILE A1207
PHE A1137
 None
 1.12A 3ln1D-5hy7A:
undetectable		 3ln1D-5hy7A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 6 VAL A 862
VAL A 801
ILE A 859
ARG A 456
 None
 1.11A 3mssC-5hy7A:
undetectable		 3mssC-5hy7A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY A 612
PRO A 615
VAL A 614
ASN A 569
LEU A 675
 None
 1.25A 3mteA-5hy7A:
undetectable		 3mteA-5hy7A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_1
(METHYLTRANSFERASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 9 SER A 857
GLY A 906
PRO A 945
SER A 886
HIS A 922
 None
 1.30A 3ndiA-5hy7A:
undetectable		 3ndiA-5hy7A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		3 / 3 THR A 390
SER A 391
ARG A 340
 None
 0.71A 3phnA-5hy7A:
undetectable		 3phnA-5hy7A:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		3 / 3 GLU A 271
PHE A 273
GLN A 270
 None
 0.99A 3r55A-5hy7A:
undetectable		 3r55A-5hy7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		3 / 3 LYS A 789
PRO A 870
LYS A 459
 None
 1.49A 4dr5L-5hy7A:
undetectable		 4dr5L-5hy7A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		3 / 3 LYS A 789
PRO A 870
LYS A 459
 None
 1.39A 4dr6L-5hy7A:
undetectable		 4dr6L-5hy7A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 HIS A 267
TYR A 265
LEU A 215
LEU A 180
TYR A 217
 None
 1.42A 4emaA-5hy7A:
undetectable		 4emaA-5hy7A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A1204
LEU A1180
ASP A1173
GLY A1172
PHE A1137
 None
 1.18A 4foxA-5hy7A:
undetectable		 4foxA-5hy7A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ASP A1022
ARG A1084
ASP A1000
 None
 0.80A 4fp9C-5hy7A:
undetectable		 4fp9C-5hy7A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ASP A1022
ARG A1084
ASP A1000
 None
 0.75A 4fp9F-5hy7A:
undetectable		 4fp9F-5hy7A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLU A  98
ALA A  88
PHE A  75
LEU A 151
ILE A 139
 None
 1.19A 4hytA-5hy7A:
undetectable		 4hytA-5hy7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLU A  98
ALA A  88
PHE A  75
LEU A 151
ILE A 139
 None
 1.20A 4hytC-5hy7A:
undetectable		 4hytC-5hy7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 902
LEU A 989
PHE A 948
ILE A 959
ILE A 921
 None
 0.99A 4i13A-5hy7A:
undetectable		 4i13A-5hy7A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		3 / 3 GLU A 554
ARG A 545
HIS A 540
 None
 0.78A 4kf9A-5hy7A:
undetectable		 4kf9A-5hy7A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 746
LEU A 462
ILE A 779
GLY A 732
LEU A 723
 None
 1.02A 4lmnA-5hy7A:
undetectable		 4lmnA-5hy7A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ASP A  64
PRO A1149
ILE A  68
ASP A  90
 None
 1.04A 4pcuA-5hy7A:
undetectable		 4pcuA-5hy7A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		3 / 3 CYH A 447
PRO A 792
ASP A 422
 None
 0.91A 4pm5A-5hy7A:
undetectable		 4pm5A-5hy7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 9 THR A  19
ILE A1118
LEU A 458
VAL A1114
ILE A  15
 None
 1.34A 4r38C-5hy7A:
undetectable		 4r38C-5hy7A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 365
LEU A 363
LEU A 312
VAL A 297
GLY A 296
 None
 1.10A 4rrwC-5hy7A:
undetectable		 4rrwC-5hy7A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 365
LEU A 363
LEU A 312
VAL A 297
GLY A 296
 None
 1.10A 4rrzC-5hy7A:
undetectable		 4rrzC-5hy7A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 902
LEU A 989
PHE A 948
ILE A 959
ILE A 921
 None
 1.01A 4x5jA-5hy7A:
undetectable		 4x5jA-5hy7A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 4 PHE A 623
ASP A 639
GLY A 694
SER A 622
 None
 1.33A 4xp9C-5hy7A:
undetectable		 4xp9C-5hy7A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER A 886
GLY A 904
SER A 916
GLY A 919
 None
None
CA  A1302 (-2.2A)
None
 0.57A 5alcL-5hy7A:
undetectable		 5alcL-5hy7A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 6 SER A 420
GLU A 419
GLY A 450
GLY A 448
 None
 0.93A 5cdnR-5hy7A:
undetectable
5cdnS-5hy7A:
undetectable		 5cdnR-5hy7A:
16.83
5cdnS-5hy7A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A  19
GLN A 788
LEU A 427
GLY A 448
GLY A 370
 None
 1.15A 5e3iA-5hy7A:
undetectable		 5e3iA-5hy7A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A 568
LEU A 659
ALA A 576
ILE A 575
THR A 632
 None
 1.48A 5ewjC-5hy7A:
undetectable
5ewjD-5hy7A:
undetectable		 5ewjC-5hy7A:
14.94
5ewjD-5hy7A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 6 GLU A 943
PRO A 944
GLY A 960
ARG A 914
 None
 1.41A 5jcnB-5hy7A:
undetectable		 5jcnB-5hy7A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
YSF3
(Chaetomium
thermophilum) 		5 / 12 ILE A 446
VAL A 428
ASN D  58
ASP A 815
ALA A 884
 None
 1.05A 5lg3E-5hy7A:
undetectable		 5lg3E-5hy7A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 6 PHE A  66
LEU A1151
ARG A1154
GLY A1153
 None
 1.00A 5o4yA-5hy7A:
undetectable		 5o4yA-5hy7A:
1.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 4 THR A 643
ASP A 639
ARG A 620
LEU A 638
 None
 1.22A 5tdmA-5hy7A:
undetectable		 5tdmA-5hy7A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ARG A1027
ARG A1084
LEU A1085
ASP A1022
 None
 1.17A 5tdzA-5hy7A:
undetectable		 5tdzA-5hy7A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 10 VAL A 862
VAL A 872
LEU A 793
THR A 794
PRO A 797
 None
 1.31A 5tt3A-5hy7A:
undetectable		 5tt3A-5hy7A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 HIS A 267
TYR A 265
LEU A 215
LEU A 180
TYR A 217
 None
 1.40A 5y2oA-5hy7A:
undetectable		 5y2oA-5hy7A:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		3 / 3 LYS A 707
PRO A 708
LYS A 710
 None
 1.25A 5y9yA-5hy7A:
undetectable		 5y9yA-5hy7A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 8 GLY A  67
ILE A  65
ASP A1171
ASP A1173
 None
 0.79A 6ag0A-5hy7A:
undetectable		 6ag0A-5hy7A:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 8 GLY A  67
ILE A  65
ASP A1171
ASP A1173
 None
 0.81A 6ag0C-5hy7A:
undetectable		 6ag0C-5hy7A:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
(Chaetomium
thermophilum) 		4 / 7 SER A 657
SER A 608
GLY A 627
LEU A 711
 None
 1.06A 6btxA-5hy7A:
undetectable		 6btxA-5hy7A:
19.23