SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 5hyo PEDV 3CLPRO
(Porcine
epidemic
diarrhea
virus) 		4 / 6 ILE A  67
CYH A  38
LEU A  60
ILE A  43
 None
 0.93A 2q83B-5hyoA:
undetectable		 2q83B-5hyoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 5hyo PEDV 3CLPRO
(Porcine
epidemic
diarrhea
virus) 		4 / 8 ILE A  37
LEU A 161
TYR A 102
GLY A 178
 None
None
IPA  A 405 (-4.6A)
None
 0.98A 2vdbA-5hyoA:
undetectable		 2vdbA-5hyoA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 5hyo PEDV 3CLPRO
(Porcine
epidemic
diarrhea
virus) 		3 / 3 TYR A 125
TYR A 160
GLY A 137
 None
 0.41A 3eteB-5hyoA:
undetectable
3eteD-5hyoA:
undetectable
3eteF-5hyoA:
undetectable		 3eteB-5hyoA:
23.89
3eteD-5hyoA:
23.89
3eteF-5hyoA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5hyo PEDV 3CLPRO
(Porcine
epidemic
diarrhea
virus) 		5 / 10 SER A 138
ILE A 135
VAL A 127
ALA A 115
ILE A 113
 None
 1.04A 4lbgA-5hyoA:
undetectable		 4lbgA-5hyoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 5hyo PEDV 3CLPRO
(Porcine
epidemic
diarrhea
virus) 		4 / 6 TYR A 102
THR A  35
GLN A  87
LEU A 176
 IPA  A 405 (-4.6A)
IPA  A 405 (-3.9A)
IPA  A 405 (-3.4A)
None
 1.04A 4qzuC-5hyoA:
undetectable		 4qzuC-5hyoA:
19.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 5hyo PEDV 3CLPRO
(Porcine
epidemic
diarrhea
virus) 		3 / 3 MET A  25
HIS A  41
GLY A 142
 None
 0.62A 5gwzB-5hyoA:
42.4		 5gwzB-5hyoA:
97.34