SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hyp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 5hyp C4B-BINDING PROTEIN
ALPHA CHAIN
M28 PROTEIN
(Homo
sapiens;
Streptococcus
pyogenes) 		3 / 3 ARG A  64
SER A  83
TYR B  62
 None
 1.00A 2q2hA-5hypA:
undetectable
2q2hB-5hypA:
undetectable		 2q2hA-5hypA:
20.81
2q2hB-5hypA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5hyp C4B-BINDING PROTEIN
ALPHA CHAIN
(Homo
sapiens) 		4 / 8 TYR A  56
THR A   7
TYR A  31
TRP A  54
 None
 1.49A 3wipC-5hypA:
undetectable
3wipD-5hypA:
undetectable		 3wipC-5hypA:
19.23
3wipD-5hypA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5hyp C4B-BINDING PROTEIN
ALPHA CHAIN
(Homo
sapiens) 		4 / 8 TRP A  54
TYR A  56
THR A   7
TYR A  31
 None
 1.49A 3wipA-5hypA:
undetectable
3wipE-5hypA:
undetectable		 3wipA-5hypA:
19.23
3wipE-5hypA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 5hyp C4B-BINDING PROTEIN
ALPHA CHAIN
(Homo
sapiens) 		4 / 5 THR A   7
PRO A   6
PHE A  59
TYR A  56
 None
 1.31A 4mf6A-5hypA:
undetectable		 4mf6A-5hypA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hyp C4B-BINDING PROTEIN
ALPHA CHAIN
(Homo
sapiens) 		4 / 6 VAL A  38
LEU A  82
SER A  83
ILE A  88
 None
 0.84A 5jw1A-5hypA:
undetectable		 5jw1A-5hypA:
11.05