SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		4 / 8 ASN A 409
LEU A 330
ALA A 333
LEU A 334
 None
 0.95A 1hwiB-5hyzA:
undetectable		 1hwiB-5hyzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		4 / 8 ASN A 409
LEU A 330
ALA A 333
LEU A 334
 None
 0.96A 1hwiC-5hyzA:
undetectable		 1hwiC-5hyzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		4 / 8 MET A 521
VAL A 425
TRP A 577
PHE A 410
 None
 1.41A 1om5A-5hyzA:
undetectable
1om5B-5hyzA:
undetectable		 1om5A-5hyzA:
22.67
1om5B-5hyzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		5 / 12 VAL A 455
LEU A 258
LEU A 224
SER A 213
LEU A 211
 None
 1.14A 1qzfA-5hyzA:
undetectable		 1qzfA-5hyzA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		5 / 12 VAL A 455
LEU A 258
LEU A 224
SER A 213
LEU A 211
 None
 1.14A 1qzfB-5hyzA:
undetectable		 1qzfB-5hyzA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		5 / 12 VAL A 455
LEU A 258
LEU A 224
SER A 213
LEU A 211
 None
 1.14A 1qzfC-5hyzA:
undetectable		 1qzfC-5hyzA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		5 / 12 VAL A 455
LEU A 258
LEU A 224
SER A 213
LEU A 211
 None
 1.14A 1qzfD-5hyzA:
2.1		 1qzfD-5hyzA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		5 / 12 VAL A 455
LEU A 258
LEU A 224
SER A 213
LEU A 211
 None
 1.14A 1qzfE-5hyzA:
2.2		 1qzfE-5hyzA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		4 / 8 TYR A 445
LEU A 412
GLY A 320
TYR A 283
 None
 1.02A 1rmtC-5hyzA:
2.9		 1rmtC-5hyzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		4 / 8 MET A 521
VAL A 425
TRP A 577
PHE A 410
 None
 1.45A 2g6hA-5hyzA:
undetectable
2g6hB-5hyzA:
undetectable		 2g6hA-5hyzA:
21.88
2g6hB-5hyzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		4 / 4 LEU A 542
PRO A 291
LEU A 543
ARG A 536
 None
 1.45A 2hrcB-5hyzA:
2.9		 2hrcB-5hyzA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		4 / 8 TRP A 577
PHE A 410
MET A 521
VAL A 425
 None
 1.36A 3b3pA-5hyzA:
undetectable
3b3pB-5hyzA:
2.4		 3b3pA-5hyzA:
22.44
3b3pB-5hyzA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		3 / 3 GLU A 306
GLY A 309
THR A 308
 None
 0.56A 3iazA-5hyzA:
undetectable		 3iazA-5hyzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		5 / 12 VAL A 317
VAL A 428
ALA A 432
SER A 434
LEU A 435
 None
 1.06A 3rr3A-5hyzA:
undetectable		 3rr3A-5hyzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		5 / 12 VAL A 317
VAL A 428
ALA A 432
SER A 434
LEU A 435
 None
 1.07A 3rr3B-5hyzA:
undetectable		 3rr3B-5hyzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		5 / 12 GLY A 443
LEU A 412
ASN A 409
ALA A 560
LEU A 531
 None
 1.09A 3vywB-5hyzA:
10.0		 3vywB-5hyzA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		5 / 12 GLN A 302
ALA A 310
GLY A 309
THR A 308
ALA A 307
 None
 1.29A 4qw1V-5hyzA:
undetectable
4qw1W-5hyzA:
undetectable		 4qw1V-5hyzA:
19.74
4qw1W-5hyzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		4 / 8 ASN A 409
TRP A 517
HIS A 416
THR A 299
 None
 1.47A 5hqaA-5hyzA:
2.5		 5hqaA-5hyzA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		5 / 9 ALA A 303
ILE A 316
LEU A 330
ILE A 314
ALA A 576
 None
 0.97A 5nunA-5hyzA:
undetectable		 5nunA-5hyzA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		4 / 5 ARG A 427
LEU A 431
PHE A 398
LEU A 393
 None
 1.03A 5x19C-5hyzA:
undetectable
5x19J-5hyzA:
undetectable		 5x19C-5hyzA:
21.39
5x19J-5hyzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		4 / 5 ARG A 427
LEU A 431
PHE A 398
LEU A 393
 None
 1.01A 5x1bP-5hyzA:
undetectable		 5x1bP-5hyzA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		4 / 5 LEU A 286
VAL A 486
GLU A 487
LEU A 472
 None
 1.01A 5xooB-5hyzA:
undetectable		 5xooB-5hyzA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA607_0
(ALPHA-AMYLASE)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		4 / 4 ARG A 510
SER A 421
ASP A 420
ASN A 450
 None
 1.48A 6ag0A-5hyzA:
undetectable		 6ag0A-5hyzA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED
(Oryza
sativa) 		5 / 12 LEU A 572
VAL A 574
SER A 575
ALA A 303
ASN A 409
 None
 1.05A 6drxA-5hyzA:
undetectable		 6drxA-5hyzA:
21.64