SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hz7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5hz7 COMP
(Neisseria
meningitidis) 		3 / 3 TRP A 159
VAL A 260
TRP A 341
 None
None
MLR  A 501 (-3.1A)
 1.30A 1c4dA-5hz7A:
undetectable
1c4dB-5hz7A:
undetectable		 1c4dA-5hz7A:
2.78
1c4dB-5hz7A:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5hz7 COMP
(Neisseria
meningitidis) 		4 / 6 VAL A   9
VAL A  51
ILE A  61
ASN A 268
 None
 0.95A 1e06A-5hz7A:
undetectable		 1e06A-5hz7A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 5hz7 COMP
(Neisseria
meningitidis) 		5 / 10 GLU A 389
ALA A 386
PRO A 415
ALA A 419
GLY A 421
 None
 1.33A 1mjqG-5hz7A:
undetectable
1mjqH-5hz7A:
undetectable		 1mjqG-5hz7A:
12.13
1mjqH-5hz7A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5hz7 COMP
(Neisseria
meningitidis) 		5 / 12 LEU A 263
ILE A 109
VAL A  98
LEU A  77
ILE A  80
 None
 1.09A 2h42C-5hz7A:
undetectable		 2h42C-5hz7A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5hz7 COMP
(Neisseria
meningitidis) 		5 / 12 ALA A 265
LEU A 281
PHE A 280
VAL A 294
GLY A  17
 None
 1.11A 2ve3A-5hz7A:
undetectable		 2ve3A-5hz7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5hz7 COMP
(Neisseria
meningitidis) 		4 / 6 PHE A 259
ALA A 163
LEU A 248
PRO A 160
 EDO  A 503 (-4.0A)
None
None
None
 0.98A 3bgdA-5hz7A:
undetectable		 3bgdA-5hz7A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5hz7 COMP
(Neisseria
meningitidis) 		4 / 7 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
NA  A 507 (-3.5A)
None
None
 0.67A 3bjwC-5hz7A:
undetectable		 3bjwC-5hz7A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5hz7 COMP
(Neisseria
meningitidis) 		4 / 8 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
NA  A 507 (-3.5A)
None
None
 0.87A 3bjwA-5hz7A:
undetectable		 3bjwA-5hz7A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5hz7 COMP
(Neisseria
meningitidis) 		4 / 6 PRO A 127
LEU A 148
ALA A 224
PRO A 126
 None
 1.32A 3gv1A-5hz7A:
undetectable
3gv1C-5hz7A:
undetectable		 3gv1A-5hz7A:
15.13
3gv1C-5hz7A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5hz7 COMP
(Neisseria
meningitidis) 		4 / 6 LEU A 148
ALA A 224
PRO A 126
PRO A 127
 None
 1.30A 3gv1A-5hz7A:
undetectable
3gv1B-5hz7A:
undetectable		 3gv1A-5hz7A:
15.13
3gv1B-5hz7A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hz7 COMP
(Neisseria
meningitidis) 		5 / 12 VAL A 344
GLY A 188
ALA A 189
LEU A 193
LEU A 161
 None
 1.04A 3hs6A-5hz7A:
undetectable		 3hs6A-5hz7A:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5hz7 COMP
(Neisseria
meningitidis) 		12 / 12 ASP A  15
LYS A  16
LYS A  43
GLU A  45
GLU A  46
ALA A  64
ASP A  66
ARG A  67
GLU A 112
PRO A 155
TRP A 231
TYR A 342
 MLR  A 501 (-2.2A)
MLR  A 501 (-2.6A)
BGC  A 504 (-2.5A)
BGC  A 504 ( 2.4A)
BGC  A 504 (-2.2A)
MLR  A 501 (-3.0A)
MLR  A 501 (-2.8A)
MLR  A 501 (-3.8A)
MLR  A 501 (-2.4A)
MLR  A 501 (-2.6A)
MLR  A 501 (-3.3A)
MLR  A 501 ( 3.4A)
 0.30A 3jyrA-5hz7A:
62.8		 3jyrA-5hz7A:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5hz7 COMP
(Neisseria
meningitidis) 		6 / 7 ASN A  13
TRP A  63
GLU A 154
TYR A 156
MET A 331
TRP A 341
 MLR  A 501 ( 4.6A)
MLR  A 501 (-4.0A)
MLR  A 501 (-2.6A)
MLR  A 501 (-2.8A)
MLR  A 501 (-3.7A)
MLR  A 501 (-3.1A)
 0.18A 3jyrA-5hz7A:
62.8		 3jyrA-5hz7A:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5hz7 COMP
(Neisseria
meningitidis) 		6 / 7 ASN A  13
TRP A  63
TYR A 156
MET A 331
TRP A 341
ARG A 345
 MLR  A 501 ( 4.6A)
MLR  A 501 (-4.0A)
MLR  A 501 (-2.8A)
MLR  A 501 (-3.7A)
MLR  A 501 (-3.1A)
BGC  A 504 ( 3.9A)
 0.60A 3jyrA-5hz7A:
62.8		 3jyrA-5hz7A:
66.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5hz7 COMP
(Neisseria
meningitidis) 		5 / 12 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 1.00A 3n8yB-5hz7A:
undetectable		 3n8yB-5hz7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5hz7 COMP
(Neisseria
meningitidis) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 MLR  A 501 ( 4.2A)
NA  A 507 (-3.5A)
None
MLR  A 501 (-2.4A)
None
 0.85A 3tbgB-5hz7A:
undetectable		 3tbgB-5hz7A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5hz7 COMP
(Neisseria
meningitidis) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 MLR  A 501 ( 4.2A)
NA  A 507 (-3.5A)
None
MLR  A 501 (-2.4A)
None
 0.83A 3tbgD-5hz7A:
undetectable		 3tbgD-5hz7A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5hz7 COMP
(Neisseria
meningitidis) 		5 / 12 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.30A 3vwqA-5hz7A:
undetectable		 3vwqA-5hz7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5hz7 COMP
(Neisseria
meningitidis) 		4 / 5 GLU A 309
ASP A 315
ASP A 288
ASN A 295
 None
None
None
NA  A 507 (-3.1A)
 1.34A 3vywD-5hz7A:
undetectable		 3vywD-5hz7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 5hz7 COMP
(Neisseria
meningitidis) 		5 / 12 ILE A 267
ALA A 106
LEU A  21
VAL A  24
ILE A  60
 None
 1.10A 4m2xG-5hz7A:
undetectable		 4m2xG-5hz7A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5hz7 COMP
(Neisseria
meningitidis) 		4 / 5 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MLR  A 501 (-2.2A)
 0.97A 4n48A-5hz7A:
undetectable		 4n48A-5hz7A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5hz7 COMP
(Neisseria
meningitidis) 		5 / 9 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
None
NA  A 506 (-3.9A)
None
None
 1.16A 4or0B-5hz7A:
undetectable		 4or0B-5hz7A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 5hz7 COMP
(Neisseria
meningitidis) 		3 / 3 LEU A 476
ASP A 477
TYR A 478
 None
 0.64A 4qc6B-5hz7A:
undetectable		 4qc6B-5hz7A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5hz7 COMP
(Neisseria
meningitidis) 		5 / 12 GLN A  50
ALA A 270
GLY A  55
THR A  54
ALA A  53
 None
 1.26A 5l66H-5hz7A:
undetectable
5l66I-5hz7A:
undetectable		 5l66H-5hz7A:
22.36
5l66I-5hz7A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5hz7 COMP
(Neisseria
meningitidis) 		5 / 12 GLN A  50
ALA A 270
GLY A  55
THR A  54
ALA A  53
 None
 1.26A 5l66V-5hz7A:
undetectable
5l66W-5hz7A:
undetectable		 5l66V-5hz7A:
22.36
5l66W-5hz7A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5hz7 COMP
(Neisseria
meningitidis) 		6 / 12 ALA A 343
ALA A 339
GLY A 167
ALA A 189
PHE A 170
VAL A 182
 None
 1.45A 5w4zA-5hz7A:
undetectable		 5w4zA-5hz7A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5hz7 COMP
(Neisseria
meningitidis) 		6 / 12 ALA A 343
ALA A 339
GLY A 167
ALA A 189
PHE A 170
VAL A 182
 None
 1.48A 5w4zB-5hz7A:
undetectable		 5w4zB-5hz7A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5hz7 COMP
(Neisseria
meningitidis) 		3 / 3 TYR A 156
ASN A 228
LEU A 114
 MLR  A 501 (-2.8A)
None
None
 0.84A 6b58A-5hz7A:
undetectable		 6b58A-5hz7A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5hz7 COMP
(Neisseria
meningitidis) 		5 / 11 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.41A 6bm5A-5hz7A:
undetectable		 6bm5A-5hz7A:
23.41