SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		4 / 5 LEU B 454
SER B 399
LEU B 400
GLY B 425
 None
 0.92A 1a4lB-5hzgB:
undetectable		 1a4lB-5hzgB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		3 / 3 ALA A 100
VAL A  94
TRP A  35
 None
 0.81A 1av2C-5hzgA:
undetectable
1av2D-5hzgA:
undetectable		 1av2C-5hzgA:
4.35
1av2D-5hzgA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 11 ALA B 264
VAL B 217
LEU B 220
ALA B 254
LEU B 262
 None
 1.07A 1jinA-5hzgB:
undetectable		 1jinA-5hzgB:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		3 / 3 ARG B 409
ARG B 295
ARG B 461
 None
 1.09A 1l7fA-5hzgB:
undetectable		 1l7fA-5hzgB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		3 / 3 ARG B 409
ARG B 295
ARG B 461
 None
 1.09A 1l7hA-5hzgB:
undetectable		 1l7hA-5hzgB:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 GLU A 140
VAL A 144
PHE A 195
VAL A 194
LEU A 179
 None
 1.18A 1oq5A-5hzgA:
undetectable		 1oq5A-5hzgA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 LEU A  10
LEU A  53
ALA A  25
VAL A  98
ILE A   6
 None
None
None
6OM  A 301 (-3.0A)
None
 1.10A 1s9pA-5hzgA:
undetectable		 1s9pA-5hzgA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		3 / 3 ALA A 100
VAL A  94
TRP A  35
 None
 0.83A 1w5uC-5hzgA:
undetectable
1w5uD-5hzgA:
undetectable		 1w5uC-5hzgA:
4.35
1w5uD-5hzgA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 10 LEU B 384
LEU B 359
ILE B 403
GLU B 347
LEU B 349
 None
 1.02A 1wopA-5hzgB:
undetectable		 1wopA-5hzgB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_2
(NEURAMINIDASE)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		4 / 5 LEU A 113
ARG A 109
ARG A 110
ILE A 105
 None
 1.43A 2cmlB-5hzgA:
undetectable		 2cmlB-5hzgA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_2
(NEURAMINIDASE)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		4 / 5 LEU A 113
ARG A 109
ARG A 110
ILE A 105
 None
 1.40A 2cmlC-5hzgA:
undetectable		 2cmlC-5hzgA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_2
(NEURAMINIDASE)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		4 / 5 LEU A 113
ARG A 109
ARG A 110
ILE A 105
 None
 1.42A 2cmlD-5hzgA:
undetectable		 2cmlD-5hzgA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		4 / 6 ALA A 106
TYR A  93
ILE A 104
ILE A 102
 None
 1.27A 2dcfA-5hzgA:
undetectable		 2dcfA-5hzgA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 10 LEU B 384
GLY B 383
LEU B 359
ILE B 356
ILE B 403
 None
 1.00A 2f8dA-5hzgB:
undetectable		 2f8dA-5hzgB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 10 LEU B 384
GLY B 383
LEU B 359
ILE B 356
ILE B 403
 None
 1.01A 2f8dB-5hzgB:
undetectable		 2f8dB-5hzgB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		3 / 3 TRP A  35
ALA A 100
VAL A  94
 None
 0.79A 2izqA-5hzgA:
undetectable
2izqB-5hzgA:
undetectable		 2izqA-5hzgA:
4.35
2izqB-5hzgA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 12 LEU B  87
LEU B 162
SER B  67
PRO B  68
GLY B  69
 None
 1.21A 2vmyB-5hzgB:
undetectable		 2vmyB-5hzgB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 12 LEU B 284
MET B 333
THR B 213
VAL B 216
LEU B 235
 None
 1.36A 3a51B-5hzgB:
undetectable		 3a51B-5hzgB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		3 / 3 TRP B 178
VAL B 216
ARG B 218
 None
 0.93A 3b0wA-5hzgB:
undetectable		 3b0wA-5hzgB:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		4 / 6 PHE B 529
GLN B 533
LEU B 447
LEU B 538
 None
 1.04A 3bgdA-5hzgB:
undetectable		 3bgdA-5hzgB:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 11 LEU B 162
ALA B 133
ALA B 136
VAL B 151
LEU B  85
 None
 1.21A 3bszE-5hzgB:
undetectable		 3bszE-5hzgB:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		3 / 3 CYH B 142
PHE B  79
PHE B 143
 None
 0.81A 3cr5X-5hzgB:
undetectable		 3cr5X-5hzgB:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 12 GLY B 317
VAL B 315
ILE B 313
ALA B 320
LEU B 282
 None
 1.00A 3fpjA-5hzgB:
undetectable		 3fpjA-5hzgB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5hzg STRIGOLACTONE
ESTERASE D14
F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Arabidopsis
thaliana;
Oryza
sativa) 		5 / 12 GLY A 246
ALA A 253
ALA B 600
PHE A 175
ALA A 216
 None
None
None
6OM  A 301 ( 4.9A)
None
 0.94A 3jb1A-5hzgA:
undetectable		 3jb1A-5hzgA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5hzg STRIGOLACTONE
ESTERASE D14
F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Arabidopsis
thaliana;
Oryza
sativa) 		5 / 12 GLY A 246
ALA A 253
ALA B 600
PHE A 175
ALA A 216
 None
None
None
6OM  A 301 ( 4.9A)
None
 1.01A 3jb3A-5hzgA:
undetectable		 3jb3A-5hzgA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 10 LEU B 627
LEU B 615
ILE B 661
LEU B 642
PHE B 673
 None
 1.19A 3jw5B-5hzgB:
undetectable		 3jw5B-5hzgB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 12 GLU B 310
PHE B 364
GLY B 362
ASP B 278
GLY B 317
 None
 1.43A 3jzjA-5hzgB:
undetectable		 3jzjA-5hzgB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 12 LEU B 361
SER B 386
CYH B 381
ASP B 376
ASP B 397
 None
 1.19A 3ko0A-5hzgB:
undetectable
3ko0B-5hzgB:
undetectable
3ko0C-5hzgB:
undetectable
3ko0D-5hzgB:
undetectable		 3ko0A-5hzgB:
8.73
3ko0B-5hzgB:
8.73
3ko0C-5hzgB:
8.73
3ko0D-5hzgB:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 11 ASP B 376
LEU B 361
SER B 386
CYH B 381
ASP B 397
 None
 1.24A 3ko0C-5hzgB:
undetectable
3ko0D-5hzgB:
undetectable
3ko0E-5hzgB:
undetectable
3ko0F-5hzgB:
undetectable		 3ko0C-5hzgB:
8.73
3ko0D-5hzgB:
8.73
3ko0E-5hzgB:
8.73
3ko0F-5hzgB:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 11 ASP B 376
LEU B 361
SER B 386
CYH B 381
ASP B 397
 None
 1.21A 3ko0E-5hzgB:
undetectable
3ko0F-5hzgB:
undetectable
3ko0G-5hzgB:
undetectable
3ko0H-5hzgB:
undetectable		 3ko0E-5hzgB:
8.73
3ko0F-5hzgB:
8.73
3ko0G-5hzgB:
8.73
3ko0H-5hzgB:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 12 ASP B 376
LEU B 361
SER B 386
CYH B 381
ASP B 397
 None
 1.25A 3ko0G-5hzgB:
undetectable
3ko0H-5hzgB:
undetectable
3ko0I-5hzgB:
undetectable
3ko0J-5hzgB:
undetectable		 3ko0G-5hzgB:
8.73
3ko0H-5hzgB:
8.73
3ko0I-5hzgB:
8.73
3ko0J-5hzgB:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 11 ASP B 397
ASP B 376
LEU B 361
SER B 386
CYH B 381
 None
 1.16A 3ko0K-5hzgB:
undetectable
3ko0L-5hzgB:
undetectable
3ko0M-5hzgB:
undetectable
3ko0N-5hzgB:
undetectable		 3ko0K-5hzgB:
8.73
3ko0L-5hzgB:
8.73
3ko0M-5hzgB:
8.73
3ko0N-5hzgB:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 11 LEU B 361
SER B 386
CYH B 381
ASP B 376
ASP B 397
 None
 1.26A 3ko0O-5hzgB:
undetectable
3ko0P-5hzgB:
undetectable
3ko0Q-5hzgB:
undetectable
3ko0R-5hzgB:
undetectable		 3ko0O-5hzgB:
8.73
3ko0P-5hzgB:
8.73
3ko0Q-5hzgB:
8.73
3ko0R-5hzgB:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		3 / 3 ALA A 100
VAL A  94
TRP A  35
 None
 0.81A 3l8lA-5hzgA:
undetectable
3l8lB-5hzgA:
undetectable		 3l8lA-5hzgA:
4.35
3l8lB-5hzgA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		3 / 3 ALA A 100
VAL A  94
TRP A  35
 None
 0.86A 3l8lC-5hzgA:
undetectable
3l8lD-5hzgA:
undetectable		 3l8lC-5hzgA:
4.35
3l8lD-5hzgA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 9 ILE B 356
LEU B 361
LEU B 373
GLU B 347
GLY B 366
 None
 1.18A 3nxuB-5hzgB:
undetectable		 3nxuB-5hzgB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 7 GLY A  27
SER A  97
LEU A 179
PHE A 175
HIS A 247
 6OM  A 301 ( 4.4A)
6OM  A 301 (-1.5A)
None
6OM  A 301 ( 4.9A)
6OM  A 301 (-2.6A)
 1.36A 3o9mA-5hzgA:
11.1		 3o9mA-5hzgA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 5hzg STRIGOLACTONE
ESTERASE D14
F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Arabidopsis
thaliana;
Oryza
sativa) 		4 / 5 ASP A  31
GLU B 693
THR B 664
SER A 187
 None
 1.05A 3p2kC-5hzgA:
2.8		 3p2kC-5hzgA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		4 / 5 SER B 363
GLU B 298
LEU B 335
LYS B 310
 None
 1.47A 3pgyB-5hzgB:
undetectable		 3pgyB-5hzgB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 10 LEU A 199
ALA A 100
GLY A 103
ILE A 105
CYH A  55
 None
 1.35A 3qpsA-5hzgA:
undetectable		 3qpsA-5hzgA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		3 / 3 TYR B 210
LEU B 162
ARG B 154
 None
 0.69A 3sufB-5hzgB:
undetectable		 3sufB-5hzgB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		4 / 5 LEU B 384
LEU B 375
MET B 389
THR B 396
 None
 1.39A 4do3A-5hzgB:
undetectable		 4do3A-5hzgB:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana;
Oryza
sativa) 		5 / 11 SER B 608
MET A 148
PHE A 180
PHE A 145
ALA A 170
 None
 1.38A 4dx7A-5hzgB:
undetectable		 4dx7A-5hzgB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		4 / 7 GLU B 298
GLN B 336
ASN B 338
ILE B 313
 None
 1.24A 4ii8A-5hzgB:
undetectable		 4ii8A-5hzgB:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		4 / 8 LEU B 235
VAL B 216
LEU B 291
LEU B 259
 None
 1.01A 4l1xA-5hzgB:
undetectable		 4l1xA-5hzgB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		4 / 6 ARG A 125
GLY A 135
ASP A 198
PRO A 124
 None
 1.01A 4lajA-5hzgA:
undetectable
4lajB-5hzgA:
undetectable		 4lajA-5hzgA:
20.68
4lajB-5hzgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		3 / 3 LEU A 242
LYS A 243
THR A 244
 None
 0.53A 4lj0A-5hzgA:
undetectable		 4lj0A-5hzgA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 12 VAL B 276
GLY B 277
SER B 246
LEU B 249
SER B 287
 None
 1.24A 4ot2A-5hzgB:
undetectable		 4ot2A-5hzgB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 TYR A  93
VAL A  12
ILE A  82
SER A  99
VAL A  59
 None
 0.83A 4rujA-5hzgA:
undetectable		 4rujA-5hzgA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		3 / 3 LYS B 585
ARG B  36
VAL B  35
 None
 0.98A 4x3uA-5hzgB:
undetectable
4x3uB-5hzgB:
undetectable		 4x3uA-5hzgB:
5.53
4x3uB-5hzgB:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		3 / 3 ASP A 198
LEU A 203
GLY A 201
 None
 0.57A 4xmfA-5hzgA:
undetectable		 4xmfA-5hzgA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana;
Oryza
sativa) 		4 / 5 TRP A 155
LEU A 162
PRO A 161
LEU B 615
 None
 1.31A 5eshA-5hzgA:
undetectable		 5eshA-5hzgA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		4 / 8 PHE A  28
GLY A  29
TYR A  69
PHE A  66
 6OM  A 301 (-4.3A)
None
None
None
 0.89A 5flcB-5hzgA:
undetectable		 5flcB-5hzgA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		4 / 8 PHE A  28
GLY A  29
TYR A  69
PHE A  66
 6OM  A 301 (-4.3A)
None
None
None
 0.90A 5flcF-5hzgA:
undetectable		 5flcF-5hzgA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 12 ASP B 397
ILE B 403
ALA B 402
LEU B 373
GLY B 383
 None
 0.87A 5i73A-5hzgB:
undetectable		 5i73A-5hzgB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 VAL A  76
ASP A  78
LEU A 119
ALA A 106
PHE A 114
 None
 1.14A 5nd7B-5hzgA:
3.4		 5nd7B-5hzgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		4 / 4 GLU B 196
THR B 197
THR B 158
LEU B 175
 None
 1.48A 5v96A-5hzgB:
undetectable		 5v96A-5hzgB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		4 / 4 GLU B 196
THR B 197
THR B 158
LEU B 175
 None
 1.48A 5v96C-5hzgB:
undetectable		 5v96C-5hzgB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		4 / 4 GLU B 196
THR B 197
THR B 158
LEU B 175
 None
 1.46A 5v96D-5hzgB:
undetectable		 5v96D-5hzgB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5hzg STRIGOLACTONE
ESTERASE D14
F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Arabidopsis
thaliana;
Oryza
sativa) 		4 / 5 PHE B 709
ASP A  62
GLU B 667
ASN A  11
 None
 1.05A 5ybbA-5hzgB:
undetectable		 5ybbA-5hzgB:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 VAL A  98
PHE A 126
PHE A 136
ILE A 141
VAL A 144
 6OM  A 301 (-3.0A)
None
None
None
None
 1.01A 6ap6A-5hzgA:
34.0		 6ap6A-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		6 / 12 VAL A  98
PHE A 126
PHE A 136
ILE A 141
VAL A 194
HIS A 247
 6OM  A 301 (-3.0A)
None
None
None
None
6OM  A 301 (-2.6A)
 1.33A 6ap6A-5hzgA:
34.0		 6ap6A-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		6 / 12 VAL A  98
PHE A 136
ILE A 141
SER A 191
PHE A 195
HIS A 247
 6OM  A 301 (-3.0A)
None
None
None
None
6OM  A 301 (-2.6A)
 1.15A 6ap6A-5hzgA:
34.0		 6ap6A-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		6 / 12 VAL A  98
PHE A 136
ILE A 141
SER A 191
VAL A 194
HIS A 247
 6OM  A 301 (-3.0A)
None
None
None
None
6OM  A 301 (-2.6A)
 1.25A 6ap6A-5hzgA:
34.0		 6ap6A-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 VAL A  98
PHE A 136
ILE A 141
VAL A 144
PHE A 195
 6OM  A 301 (-3.0A)
None
None
None
None
 1.14A 6ap6A-5hzgA:
34.0		 6ap6A-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 VAL A  98
PHE A 126
PHE A 136
ILE A 141
VAL A 144
 6OM  A 301 (-3.0A)
None
None
None
None
 1.03A 6ap6B-5hzgA:
34.1		 6ap6B-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		6 / 12 VAL A  98
PHE A 126
PHE A 136
ILE A 141
VAL A 194
HIS A 247
 6OM  A 301 (-3.0A)
None
None
None
None
6OM  A 301 (-2.6A)
 1.34A 6ap6B-5hzgA:
34.1		 6ap6B-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		6 / 12 VAL A  98
PHE A 136
ILE A 141
SER A 191
PHE A 195
HIS A 247
 6OM  A 301 (-3.0A)
None
None
None
None
6OM  A 301 (-2.6A)
 1.15A 6ap6B-5hzgA:
34.1		 6ap6B-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		6 / 12 VAL A  98
PHE A 136
ILE A 141
SER A 191
VAL A 194
HIS A 247
 6OM  A 301 (-3.0A)
None
None
None
None
6OM  A 301 (-2.6A)
 1.26A 6ap6B-5hzgA:
34.1		 6ap6B-5hzgA:
81.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 VAL A  98
PHE A 136
ILE A 141
VAL A 144
PHE A 195
 6OM  A 301 (-3.0A)
None
None
None
None
 1.15A 6ap6B-5hzgA:
34.1		 6ap6B-5hzgA:
81.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		5 / 12 VAL B 276
GLY B 277
SER B 246
LEU B 249
SER B 287
 None
 1.22A 6ci6A-5hzgB:
undetectable		 6ci6A-5hzgB:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 12 ASP A  78
LEU A 119
ALA A 106
PHE A 114
LEU A 117
 None
 1.11A 6ew0G-5hzgA:
3.3		 6ew0G-5hzgA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		4 / 4 ALA A 147
ALA A 150
ALA A 163
ALA A 166
 None
 0.73A 6gtqA-5hzgA:
0.8
6gtqB-5hzgA:
0.3		 6gtqA-5hzgA:
21.62
6gtqB-5hzgA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		4 / 4 ALA A 163
ALA A 166
ALA A 147
ALA A 150
 None
 0.72A 6gtqA-5hzgA:
0.8
6gtqB-5hzgA:
0.3		 6gtqA-5hzgA:
21.62
6gtqB-5hzgA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 11 LEU A 199
PRO A 124
MET A 101
LEU A 127
PHE A 126
 None
 1.47A 6hupA-5hzgA:
undetectable
6hupB-5hzgA:
undetectable		 6hupA-5hzgA:
15.36
6hupB-5hzgA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 10 LEU A 199
PRO A 124
MET A 101
LEU A 127
PHE A 126
 None
 1.50A 6hupD-5hzgA:
undetectable
6hupE-5hzgA:
undetectable		 6hupD-5hzgA:
15.36
6hupE-5hzgA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 5hzg STRIGOLACTONE
ESTERASE D14
(Arabidopsis
thaliana) 		5 / 10 LEU A 199
PRO A 124
MET A 101
LEU A 229
PHE A 126
 None
 1.48A 6hupD-5hzgA:
undetectable
6hupE-5hzgA:
undetectable		 6hupD-5hzgA:
15.36
6hupE-5hzgA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
(Oryza
sativa) 		4 / 8 TRP B  93
HIS B 179
GLU B 693
GLU B 700
 None
 1.16A 6mn4C-5hzgB:
undetectable		 6mn4C-5hzgB:
17.52