SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hzl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 11 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 1.05A 1dhiB-5hzlB:
undetectable		 1dhiB-5hzlB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 0.99A 1dhjB-5hzlB:
undetectable		 1dhjB-5hzlB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 1.01A 1draA-5hzlB:
undetectable		 1draA-5hzlB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 1.02A 1draB-5hzlB:
undetectable		 1draB-5hzlB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 1.01A 1drbB-5hzlB:
undetectable		 1drbB-5hzlB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 1.01A 1ra2A-5hzlB:
undetectable		 1ra2A-5hzlB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 0.99A 1ra3A-5hzlB:
undetectable		 1ra3A-5hzlB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 0.95A 1rb3B-5hzlB:
undetectable		 1rb3B-5hzlB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 10 LEU B  64
LEU B  69
ILE B  29
GLU B 104
ILE B  81
 None
 1.21A 1wopA-5hzlB:
2.6		 1wopA-5hzlB:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 0.99A 2drcA-5hzlB:
undetectable		 2drcA-5hzlB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 1.02A 2drcB-5hzlB:
undetectable		 2drcB-5hzlB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		4 / 6 ASP B 118
VAL B 142
PHE B 116
PRO B 139
 None
 1.28A 2q6oB-5hzlB:
undetectable		 2q6oB-5hzlB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 10 ALA B  32
LEU B  96
LEU B  69
LEU B  59
LEU B  72
 None
 1.19A 2riwA-5hzlB:
undetectable
2riwB-5hzlB:
undetectable		 2riwA-5hzlB:
23.24
2riwB-5hzlB:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 9 PHE B 116
ILE B 113
ASP B  68
LEU B  69
GLY B  66
 None
 1.49A 2tsrD-5hzlB:
undetectable		 2tsrD-5hzlB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU B  37
PHE B  24
ILE B  57
PRO B  58
LEU B  72
 None
 1.12A 2w3bA-5hzlB:
undetectable		 2w3bA-5hzlB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU B  37
PHE B  24
ILE B  57
PRO B  58
LEU B  72
 None
 1.11A 2w3bB-5hzlB:
undetectable		 2w3bB-5hzlB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU B  37
PHE B  24
ILE B  57
PRO B  58
LEU B  72
 None
 1.09A 2w3mA-5hzlB:
undetectable		 2w3mA-5hzlB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE B  20
ALA B  32
LEU B  59
PHE B  24
ASN B  73
 None
 1.25A 2w3mB-5hzlB:
undetectable		 2w3mB-5hzlB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 TRP B  86
ALA B 108
ILE B 106
LEU B  93
LEU B 100
 None
 1.08A 2w3vA-5hzlB:
undetectable		 2w3vA-5hzlB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 10 ALA B  32
LEU B  96
LEU B  69
LEU B  59
LEU B  72
 None
 1.17A 2xn6A-5hzlB:
undetectable
2xn6B-5hzlB:
undetectable		 2xn6A-5hzlB:
23.10
2xn6B-5hzlB:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 0.99A 3drcA-5hzlB:
undetectable		 3drcA-5hzlB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 1.01A 3drcB-5hzlB:
undetectable		 3drcB-5hzlB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		4 / 7 TYR B 121
LEU B 172
LEU B 124
PHE B 116
 None
 1.22A 3nk2X-5hzlB:
undetectable		 3nk2X-5hzlB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 11 ALA B 108
ASP B 128
VAL B 127
VAL B 115
ILE B 106
 None
 0.96A 3oxvD-5hzlB:
undetectable		 3oxvD-5hzlB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 10 ALA B 108
ASP B 128
VAL B 127
VAL B 115
ILE B 106
 None
 1.04A 3oxwB-5hzlB:
undetectable		 3oxwB-5hzlB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 1.03A 3tq9A-5hzlB:
undetectable		 3tq9A-5hzlB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 11 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 1.10A 3tqbA-5hzlB:
undetectable		 3tqbA-5hzlB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 1.02A 4dfrB-5hzlB:
undetectable		 4dfrB-5hzlB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		4 / 8 PRO B 255
ILE B 240
LEU B 281
ILE B 225
 None
 0.93A 4dtaB-5hzlB:
undetectable		 4dtaB-5hzlB:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 1.00A 4fhbA-5hzlB:
undetectable		 4fhbA-5hzlB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU B  37
PHE B  24
ILE B  57
PRO B  58
LEU B  72
 None
 1.11A 4m6kA-5hzlB:
undetectable		 4m6kA-5hzlB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 0.98A 4nx6A-5hzlB:
undetectable		 4nx6A-5hzlB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 0.99A 4nx7A-5hzlB:
undetectable		 4nx7A-5hzlB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B 155
GLY B 156
SER B 158
ILE B 113
GLY B 110
 None
None
PG5  B 408 ( 4.2A)
None
None
 1.26A 4obwA-5hzlB:
undetectable		 4obwA-5hzlB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 0.99A 4p3rA-5hzlB:
undetectable		 4p3rA-5hzlB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 1.00A 4pstA-5hzlB:
undetectable		 4pstA-5hzlB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B 155
LEU B 177
ASN B 180
MET B 144
PHE B 116
 None
 1.33A 4zo1X-5hzlB:
undetectable		 4zo1X-5hzlB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 GLY B  35
ILE B 113
GLY B  91
GLY B  66
LEU B  72
 CA  B 407 (-4.1A)
None
None
None
None
 1.07A 5eqbA-5hzlB:
undetectable		 5eqbA-5hzlB:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 0.99A 5z6jA-5hzlB:
undetectable		 5z6jA-5hzlB:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hzl LMO2445 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA B  80
LEU B  72
ILE B  85
LEU B  93
ILE B 106
 None
 0.97A 5z6kA-5hzlB:
undetectable		 5z6kA-5hzlB:
19.28