SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 6 PHE A 802
LEU A 841
VAL A 814
MET A 813
 None
 0.57A 1hk1A-5hzrA:
undetectable		 1hk1A-5hzrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 7 PHE A 802
LEU A 841
VAL A 814
MET A 813
 None
 0.56A 1hk3A-5hzrA:
undetectable		 1hk3A-5hzrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 TYR A 701
ARG A 649
GLN A 645
 None
 0.60A 1tw4A-5hzrA:
undetectable		 1tw4A-5hzrA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 4 LEU A 592
SER A 591
TYR A 595
LEU A 596
 None
 1.23A 1xz1A-5hzrA:
undetectable		 1xz1A-5hzrA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 4 LEU A 592
SER A 591
TYR A 595
LEU A 596
 None
 1.22A 1xz3A-5hzrA:
undetectable		 1xz3A-5hzrA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		5 / 10 ILE A 798
ILE A 881
LEU A 995
VAL A 892
ILE A 966
 None
 1.17A 2nnhB-5hzrA:
undetectable		 2nnhB-5hzrA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 8 LEU A 844
LYS A 843
ASN A 846
ARG A 842
 None
 1.10A 2xn3A-5hzrA:
undetectable
2xn3B-5hzrA:
undetectable		 2xn3A-5hzrA:
19.84
2xn3B-5hzrA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 PHE A 943
VAL A 892
ILE A 965
GLU A1073
ILE A1076
 None
 1.16A 4a97B-5hzrA:
undetectable
4a97C-5hzrA:
undetectable		 4a97B-5hzrA:
17.42
4a97C-5hzrA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 ARG A 475
THR A 738
TRP A 722
 SO4  A1208 (-2.8A)
None
None
 1.24A 4d7hA-5hzrA:
undetectable		 4d7hA-5hzrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 7 SER A 591
GLN A 558
LEU A 577
ASP A 579
 None
 1.22A 4hxyB-5hzrA:
undetectable		 4hxyB-5hzrA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		5 / 5 VAL A 797
LEU A1008
ILE A 998
LEU A 997
ARG A 996
 None
 1.24A 4mghA-5hzrA:
undetectable		 4mghA-5hzrA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 LYS A 635
LYS A 799
ALA A1001
 None
 1.00A 4ot2A-5hzrA:
1.8		 4ot2A-5hzrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 7 PHE A 896
LEU A 946
MET A 905
MET A 944
 None
 0.93A 4rjdB-5hzrA:
undetectable		 4rjdB-5hzrA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 6 LEU A 956
LEU A 917
PHE A 935
THR A 960
 None
 1.06A 4udaA-5hzrA:
undetectable		 4udaA-5hzrA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 ARG A 475
THR A 738
TRP A 722
 SO4  A1208 (-2.8A)
None
None
 1.24A 4ug5A-5hzrA:
undetectable		 4ug5A-5hzrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 ARG A 475
THR A 738
TRP A 722
 SO4  A1208 (-2.8A)
None
None
 1.18A 4uglA-5hzrA:
undetectable		 4uglA-5hzrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 8 ASN A 859
PRO A 860
PHE A 849
TYR A1112
 None
 0.92A 4v2zC-5hzrA:
undetectable		 4v2zC-5hzrA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 LEU A 592
GLY A 575
PRO A 730
LEU A 729
LEU A 568
 None
None
None
KH2  A1204 (-4.6A)
None
 1.32A 4x61A-5hzrA:
3.8		 4x61A-5hzrA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 ARG A 912
ASP A 879
TYR A1090
 None
 0.79A 4yo9B-5hzrA:
undetectable		 4yo9B-5hzrA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		5 / 10 PHE A 739
VAL A 766
LEU A 725
PHE A 733
THR A 483
 None
 1.35A 4zmeB-5hzrA:
undetectable		 4zmeB-5hzrA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 7 ILE A 587
GLY A 552
THR A 794
TRP A 625
 None
 1.10A 4zxiA-5hzrA:
2.6		 4zxiA-5hzrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 8 ASN A 859
PRO A 860
PHE A 849
TYR A1112
 None
 1.07A 5amkA-5hzrA:
undetectable		 5amkA-5hzrA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 5 GLN A 645
ILE A 648
ILE A 673
TYR A 634
 None
 1.27A 5dnvA-5hzrA:
undetectable		 5dnvA-5hzrA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 ARG A 475
THR A 738
TRP A 722
 SO4  A1208 (-2.8A)
None
None
 1.25A 5g6cA-5hzrA:
undetectable		 5g6cA-5hzrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 8 GLY A 873
GLN A 806
ALA A 807
PHE A 802
 None
 0.99A 5xu8A-5hzrA:
undetectable		 5xu8A-5hzrA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 ARG A 768
HIS A 771
ARG A 775
 KH2  A1203 (-4.6A)
None
KH2  A1203 (-3.5A)
 1.04A 6dwdD-5hzrA:
undetectable		 6dwdD-5hzrA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 ILE A 998
SER A 969
ASP A 623
ILE A1007
LYS A 631
 None
 1.28A 6dwnB-5hzrA:
undetectable		 6dwnB-5hzrA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 5 LEU A 790
ILE A 881
MET A 581
GLY A 584
 None
None
SO4  A1206 (-3.9A)
SO4  A1206 (-3.6A)
 1.07A 6hd6A-5hzrA:
undetectable		 6hd6A-5hzrA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN
(Thermothelomyces
thermophila) 		4 / 7 ARG A 918
TYR A 916
GLU A 906
ASP A 903
 None
 1.22A 6mn5B-5hzrA:
undetectable		 6mn5B-5hzrA:
7.92