SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 VAL A 375
VAL A 417
ILE A 427
ASN A 634
 None
 0.97A 1e06A-5hzvA:
1.8		 1e06A-5hzvA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 LEU A 671
ILE A 696
THR A 460
MET A 688
 None
 1.28A 1kglA-5hzvA:
undetectable		 1kglA-5hzvA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 SER A 622
THR A 592
ASN A 517
LEU A 614
 None
 1.07A 1lhvA-5hzvA:
undetectable		 1lhvA-5hzvA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 GLU A 478
TRP A 597
LYS A 640
 MAL  A1001 (-3.1A)
MAL  A1001 (-4.8A)
None
 1.18A 1qu2A-5hzvA:
undetectable		 1qu2A-5hzvA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 SER A 481
ILE A 602
ILE A 483
THR A 612
 None
 1.00A 1sbrB-5hzvA:
undetectable		 1sbrB-5hzvA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ALA A 670
ILE A 475
VAL A 464
LEU A 443
ILE A 446
 None
 1.26A 2h42A-5hzvA:
undetectable		 2h42A-5hzvA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PRO A 858
LEU A 856
ARG A 929
GLY A 853
 None
 1.23A 2hs2B-5hzvA:
undetectable		 2hs2B-5hzvA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ASP A 564
THR A 560
LYS A 567
ASP A 725
 None
 1.23A 2j2pE-5hzvA:
undetectable
2j2pF-5hzvA:
undetectable		 2j2pE-5hzvA:
15.88
2j2pF-5hzvA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 GLY A 898
PRO A 942
LYS A 943
THR A 944
 None
 0.89A 2m2oB-5hzvA:
undetectable		 2m2oB-5hzvA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ASP A 487
ASN A 485
THR A 612
 None
 0.59A 2pymB-5hzvA:
undetectable		 2pymB-5hzvA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A 464
ALA A 472
PHE A 459
PRO A 458
 None
 1.07A 2q6oA-5hzvA:
undetectable		 2q6oA-5hzvA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ALA A 555
LEU A 559
ALA A 713
THR A 712
 None
 0.92A 3b6hA-5hzvA:
undetectable		 3b6hA-5hzvA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PHE A 625
ALA A 529
LEU A 614
PRO A 526
 None
 0.99A 3bgdA-5hzvA:
undetectable		 3bgdA-5hzvA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A 477
GLY A 667
PRO A 596
LYS A 672
 None
 0.84A 3bjwC-5hzvA:
undetectable		 3bjwC-5hzvA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A 477
GLY A 667
PRO A 596
LYS A 672
 None
 0.94A 3bjwA-5hzvA:
undetectable		 3bjwA-5hzvA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PRO A 493
LEU A 514
ALA A 590
PRO A 492
 None
 1.28A 3gv1A-5hzvA:
undetectable
3gv1C-5hzvA:
undetectable		 3gv1A-5hzvA:
13.26
3gv1C-5hzvA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 514
ALA A 590
PRO A 492
PRO A 493
 None
 1.27A 3gv1A-5hzvA:
undetectable
3gv1B-5hzvA:
undetectable		 3gv1A-5hzvA:
13.26
3gv1B-5hzvA:
13.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A 381
LYS A 382
LYS A 409
GLU A 411
GLU A 412
ALA A 430
ASP A 432
ARG A 433
GLU A 478
 MAL  A1001 (-3.9A)
MAL  A1001 (-3.3A)
None
None
None
MAL  A1001 (-3.2A)
MAL  A1001 (-2.8A)
MAL  A1001 (-4.0A)
MAL  A1001 (-3.1A)
 0.95A 3jyrA-5hzvA:
61.5		 3jyrA-5hzvA:
81.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		10 / 12 ASP A 381
LYS A 382
LYS A 409
GLU A 411
GLU A 412
ALA A 430
ASP A 432
GLU A 478
PRO A 521
TRP A 597
 MAL  A1001 (-3.9A)
MAL  A1001 (-3.3A)
None
None
None
MAL  A1001 (-3.2A)
MAL  A1001 (-2.8A)
MAL  A1001 (-3.1A)
MAL  A1001 (-3.9A)
MAL  A1001 (-4.8A)
 0.76A 3jyrA-5hzvA:
61.5		 3jyrA-5hzvA:
81.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		7 / 7 ASN A 379
TRP A 429
GLU A 520
TYR A 522
MET A 697
TRP A 707
ARG A 711
 MAL  A1001 (-4.1A)
MAL  A1001 (-4.3A)
MAL  A1001 (-3.3A)
MAL  A1001 (-4.0A)
MAL  A1001 ( 4.4A)
MAL  A1001 (-4.0A)
None
 0.72A 3jyrA-5hzvA:
61.5		 3jyrA-5hzvA:
81.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 563
LEU A 527
GLY A 554
ALA A 555
LEU A 728
 None
 0.98A 3n8yB-5hzvA:
undetectable		 3n8yB-5hzvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ILE A 528
GLN A 732
ALA A 729
LEU A 728
ALA A 529
 None
 1.07A 3ozvB-5hzvA:
undetectable		 3ozvB-5hzvA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 523
GLY A 667
LEU A 666
GLU A 478
ALA A 598
 None
None
None
MAL  A1001 (-3.1A)
None
 0.81A 3tbgB-5hzvA:
undetectable		 3tbgB-5hzvA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 523
GLY A 667
LEU A 666
GLU A 478
ALA A 598
 None
None
None
MAL  A1001 (-3.1A)
None
 0.80A 3tbgD-5hzvA:
undetectable		 3tbgD-5hzvA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 598
TYR A 384
TYR A 577
ASN A 601
GLY A 595
 None
 1.33A 3vwqA-5hzvA:
undetectable		 3vwqA-5hzvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 633
ALA A 472
LEU A 387
VAL A 390
ILE A 426
 None
 1.09A 4m2xG-5hzvA:
undetectable		 4m2xG-5hzvA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 LEU A 776
ILE A 829
ILE A 784
VAL A 827
 None
 0.76A 4ojbA-5hzvA:
undetectable		 4ojbA-5hzvA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA A 631
ALA A 472
LEU A 470
LEU A 629
VAL A 628
 None
 1.16A 4or0B-5hzvA:
undetectable		 4or0B-5hzvA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA A 709
ALA A 705
GLY A 533
ALA A 555
PHE A 536
VAL A 548
 None
 1.49A 5w4zA-5hzvA:
undetectable		 5w4zA-5hzvA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 ASP A 725
ALA A 729
LYS A 556
LEU A 559
 None
 0.94A 6ci6A-5hzvA:
undetectable		 6ci6A-5hzvA:
8.21