SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ALA A 560
PHE A 468
GLY A 452
LEU A 562
PRO A 565
 None
 1.33A 1cmcA-5hzwA:
undetectable
1cmcB-5hzwA:
undetectable		 1cmcA-5hzwA:
10.14
1cmcB-5hzwA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 VAL A  63
VAL A 105
ILE A 115
ASN A 322
 NAG  A 801 ( 4.8A)
None
None
None
 0.95A 1e06A-5hzwA:
undetectable		 1e06A-5hzwA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 SER A 558
HIS A 465
LEU A 478
LEU A 497
ILE A 568
 None
 1.31A 1ee2A-5hzwA:
undetectable		 1ee2A-5hzwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 SER A 558
HIS A 465
LEU A 478
LEU A 497
ILE A 568
 None
 1.37A 1ee2B-5hzwA:
undetectable		 1ee2B-5hzwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 SER A 310
THR A 280
ASN A 205
LEU A 302
 None
 1.05A 1lhvA-5hzwA:
undetectable		 1lhvA-5hzwA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 LEU A 562
PRO A 565
ALA A 560
PHE A 468
GLY A 452
 None
 1.32A 1mjqA-5hzwA:
undetectable
1mjqB-5hzwA:
undetectable		 1mjqA-5hzwA:
10.14
1mjqB-5hzwA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 LEU A 562
PRO A 565
ALA A 560
PHE A 468
GLY A 452
 None
 1.32A 1mjqC-5hzwA:
undetectable
1mjqD-5hzwA:
undetectable		 1mjqC-5hzwA:
10.14
1mjqD-5hzwA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 LEU A 562
PRO A 565
ALA A 560
PHE A 468
GLY A 452
 None
 1.33A 1mjqG-5hzwA:
undetectable
1mjqH-5hzwA:
undetectable		 1mjqG-5hzwA:
10.14
1mjqH-5hzwA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 LEU A 640
ALA A 712
VAL A 638
LEU A 651
ASP A 648
 None
 1.29A 1rlbE-5hzwA:
undetectable		 1rlbE-5hzwA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 499
LEU A 469
VAL A 505
GLU A 479
LEU A 478
 None
 1.20A 2bxfA-5hzwA:
undetectable		 2bxfA-5hzwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 GLN A 420
ALA A 419
ALA A 217
GLY A 221
ALA A 243
 None
 1.03A 2f16H-5hzwA:
undetectable
2f16I-5hzwA:
undetectable		 2f16H-5hzwA:
16.72
2f16I-5hzwA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 GLN A 420
ALA A 419
ALA A 217
GLY A 221
ALA A 243
 None
 1.03A 2f16V-5hzwA:
undetectable
2f16W-5hzwA:
undetectable		 2f16V-5hzwA:
16.72
2f16W-5hzwA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 THR A 148
GLN A 380
ALA A 379
ALA A 358
ALA A 356
 None
 1.19A 2f16V-5hzwA:
undetectable
2f16W-5hzwA:
undetectable		 2f16V-5hzwA:
16.72
2f16W-5hzwA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ASP A 252
THR A 248
LYS A 255
ASP A 413
 None
 1.26A 2j2pE-5hzwA:
undetectable
2j2pF-5hzwA:
undetectable		 2j2pE-5hzwA:
15.31
2j2pF-5hzwA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 PRO A 657
PRO A 625
GLY A 626
TYR A 658
 None
 1.12A 2jkjD-5hzwA:
undetectable		 2jkjD-5hzwA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 PRO A 657
PRO A 625
GLY A 626
TYR A 658
 None
 1.12A 2jkjF-5hzwA:
undetectable		 2jkjF-5hzwA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A 152
ALA A 160
PHE A 147
PRO A 146
 None
 1.02A 2q6oA-5hzwA:
undetectable		 2q6oA-5hzwA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 319
LEU A 335
PHE A 334
VAL A 348
GLY A  71
 None
 1.10A 2ve3A-5hzwA:
undetectable		 2ve3A-5hzwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 MET A 385
GLU A 166
ASP A  69
 MAL  A 803 ( 3.5A)
MAL  A 803 (-2.7A)
None
 0.98A 3a25A-5hzwA:
undetectable		 3a25A-5hzwA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A 165
GLY A 355
PRO A 284
LYS A 360
 None
 0.76A 3bjwC-5hzwA:
undetectable		 3bjwC-5hzwA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A 165
GLY A 355
PRO A 284
LYS A 360
 None
 0.91A 3bjwA-5hzwA:
undetectable		 3bjwA-5hzwA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 202
ALA A 278
PRO A 180
PRO A 181
 None
 1.35A 3gv1A-5hzwA:
undetectable
3gv1B-5hzwA:
undetectable		 3gv1A-5hzwA:
11.00
3gv1B-5hzwA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 4 GLN A 448
PRO A 718
VAL A 623
GLU A 716
 None
 1.41A 3huoA-5hzwA:
undetectable		 3huoA-5hzwA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 LEU A 572
SER A 485
ILE A 514
PRO A 515
GLY A 513
 None
 1.37A 3ijxB-5hzwA:
8.3
3ijxD-5hzwA:
8.1		 3ijxB-5hzwA:
17.77
3ijxD-5hzwA:
17.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		6 / 7 ASN A  67
GLU A 208
TYR A 210
MET A 385
TRP A 395
ARG A 399
 MAL  A 803 ( 4.4A)
MAL  A 803 (-3.5A)
MAL  A 803 (-3.0A)
MAL  A 803 ( 3.5A)
MAL  A 803 ( 3.0A)
None
 0.82A 3jyrA-5hzwA:
59.8		 3jyrA-5hzwA:
58.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		6 / 7 ASN A  67
TRP A 117
GLU A 208
TYR A 210
MET A 385
TRP A 395
 MAL  A 803 ( 4.4A)
MAL  A 803 (-3.6A)
MAL  A 803 (-3.5A)
MAL  A 803 (-3.0A)
MAL  A 803 ( 3.5A)
MAL  A 803 ( 3.0A)
 0.43A 3jyrA-5hzwA:
59.8		 3jyrA-5hzwA:
58.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 GLN A 420
ALA A 419
ALA A 217
GLY A 221
ALA A 243
 None
 1.04A 3mg0V-5hzwA:
undetectable
3mg0W-5hzwA:
undetectable		 3mg0V-5hzwA:
16.72
3mg0W-5hzwA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 TYR A 444
THR A 445
ARG A 632
LEU A 719
 None
 1.48A 3qelC-5hzwA:
undetectable		 3qelC-5hzwA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 ALA A 727
GLU A 617
ALA A 643
MET A 669
 None
 1.31A 3r9tC-5hzwA:
undetectable		 3r9tC-5hzwA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 211
GLY A 355
LEU A 354
GLU A 166
ALA A 286
 MAL  A 803 ( 4.5A)
None
None
MAL  A 803 (-2.7A)
None
 0.82A 3tbgB-5hzwA:
undetectable		 3tbgB-5hzwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 211
GLY A 355
LEU A 354
GLU A 166
ALA A 286
 MAL  A 803 ( 4.5A)
None
None
MAL  A 803 (-2.7A)
None
 0.80A 3tbgD-5hzwA:
undetectable		 3tbgD-5hzwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 650
LEU A 640
VAL A 604
ILE A 710
VAL A 435
 None
 1.26A 3w68C-5hzwA:
2.0		 3w68C-5hzwA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 SER A 407
ARG A 409
ILE A 403
ASP A 262
 None
 1.04A 4d33A-5hzwA:
undetectable		 4d33A-5hzwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 SER A 407
ARG A 409
ILE A 403
ASP A 262
 None
 1.04A 4d33B-5hzwA:
undetectable		 4d33B-5hzwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 SER A 407
ARG A 409
ILE A 403
ASP A 262
 None
 1.04A 4d39A-5hzwA:
undetectable		 4d39A-5hzwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 SER A 407
ARG A 409
ILE A 403
ASP A 262
 None
 1.04A 4d39B-5hzwA:
undetectable		 4d39B-5hzwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 467
LEU A 497
LEU A 518
ALA A 519
TRP A 549
 None
 1.29A 4fn9B-5hzwA:
undetectable		 4fn9B-5hzwA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 4 HIS A 517
GLU A 463
HIS A 465
LEU A 480
 None
 1.38A 4m2rA-5hzwA:
undetectable		 4m2rA-5hzwA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 177
ASN A 173
LEU A 170
ILE A 290
 None
 1.16A 4okxA-5hzwA:
undetectable		 4okxA-5hzwA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA A 319
ALA A 160
LEU A 158
LEU A 317
VAL A 316
 None
 1.14A 4or0B-5hzwA:
undetectable		 4or0B-5hzwA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 130
GLY A 124
GLN A 127
ILE A 115
PHE A 122
 None
 1.43A 4p6xI-5hzwA:
undetectable		 4p6xI-5hzwA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ASP A 113
GLU A 329
SER A 450
 NAG  A 801 ( 3.4A)
None
None
 0.82A 5bw4B-5hzwA:
undetectable		 5bw4B-5hzwA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLN A 104
ALA A 324
GLY A 109
THR A 108
ALA A 107
 None
 1.27A 5l66H-5hzwA:
undetectable
5l66I-5hzwA:
undetectable		 5l66H-5hzwA:
16.43
5l66I-5hzwA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLN A 104
ALA A 324
GLY A 109
THR A 108
ALA A 107
 None
 1.27A 5l66V-5hzwA:
undetectable
5l66W-5hzwA:
undetectable		 5l66V-5hzwA:
16.43
5l66W-5hzwA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 624
SER A 392
THR A 108
GLY A 129
LEU A 130
 None
 1.31A 5m50E-5hzwA:
undetectable		 5m50E-5hzwA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 ASP A 413
ALA A 417
LYS A 244
LEU A 247
 None
 1.03A 6ci6A-5hzwA:
2.6		 6ci6A-5hzwA:
8.25