SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_A_RALA600_1 (ESTROGEN RECEPTOR)	5hzx	NUDIX (NUCLEOSIDE DIPHOSPHATE LINKED MOIETY X)-TYPE MOTIF 1 (Danio rerio)	5 / 12	ALA A 49 GLU A 52 LEU A 53 LEU A 7 ILE A 70	None None None 2GE A 201 ( 4.0A) None	1.09A	1errA-5hzxA: undetectable	1errA-5hzxA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JFA_B_RALB600_1 (ESTROGEN RECEPTOR)	5hzx	NUDIX (NUCLEOSIDE DIPHOSPHATE LINKED MOIETY X)-TYPE MOTIF 1 (Danio rerio)	5 / 12	ALA A 49 GLU A 52 LEU A 53 LEU A 7 GLY A 68	None None None 2GE A 201 ( 4.0A) None	1.11A	2jfaB-5hzxA: undetectable	2jfaB-5hzxA: 25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YGO_A_PCFA1213_0 (WNT INHIBITORY FACTOR 1)	5hzx	NUDIX (NUCLEOSIDE DIPHOSPHATE LINKED MOIETY X)-TYPE MOTIF 1 (Danio rerio)	5 / 12	LEU A 9 ILE A 67 ILE A 85 PHE A 133 ILE A 108	2GE A 201 (-4.0A) None None None None	1.00A	2ygoA-5hzxA: undetectable	2ygoA-5hzxA: 16.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C9W_A_VGHA1158_1 (7,8-DIHYDRO-8-OXOGUA NINE TRIPHOSPHATASE)	5hzx	NUDIX (NUCLEOSIDE DIPHOSPHATE LINKED MOIETY X)-TYPE MOTIF 1 (Danio rerio)	10 / 12	LEU A 9 ASN A 33 PHE A 72 PHE A 74 MET A 81 VAL A 83 TRP A 117 ASP A 119 ASP A 120 PHE A 139	2GE A 201 (-4.0A) 2GE A 201 ( 3.2A) 2GE A 201 (-3.5A) 2GE A 201 (-4.8A) 2GE A 201 (-3.8A) 2GE A 201 ( 4.9A) 2GE A 201 (-3.9A) 2GE A 201 (-2.8A) 2GE A 201 (-2.9A) 2GE A 201 ( 4.0A)	0.63A	4c9wA-5hzxA: 27.9	4c9wA-5hzxA: 62.86

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ERR_A_RALA600_1","ESTROGEN RECEPTOR","5hzx","NUDIX (NUCLEOSIDE DIPHOSPHATE LINKED MOIETY X)-TYPE MOTIF 1","Danio rerio",5,"ALA A  49;GLU A  52;LEU A  53;LEU A   7;ILE A  70","None;None;None;2GE A 201 ( 4.0A);None","1.09A","1errA-5hzxA:undetectable","1errA-5hzxA:20.54"],["2JFA_B_RALB600_1","ESTROGEN RECEPTOR","5hzx","NUDIX (NUCLEOSIDE DIPHOSPHATE LINKED MOIETY X)-TYPE MOTIF 1","Danio rerio",5,"ALA A  49;GLU A  52;LEU A  53;LEU A   7;GLY A  68","None;None;None;2GE A 201 ( 4.0A);None","1.11A","2jfaB-5hzxA:undetectable","2jfaB-5hzxA:25.51"],["2YGO_A_PCFA1213_0","WNT INHIBITORY FACTOR 1","5hzx","NUDIX (NUCLEOSIDE DIPHOSPHATE LINKED MOIETY X)-TYPE MOTIF 1","Danio rerio",5,"LEU A   9;ILE A  67;ILE A  85;PHE A 133;ILE A 108","2GE A 201 (-4.0A);None;None;None;None","1.00A","2ygoA-5hzxA:undetectable","2ygoA-5hzxA:16.51"],["4C9W_A_VGHA1158_1","7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE","5hzx","NUDIX (NUCLEOSIDE DIPHOSPHATE LINKED MOIETY X)-TYPE MOTIF 1","Danio rerio",10,"LEU A   9;ASN A  33;PHE A  72;PHE A  74;MET A  81;VAL A  83;TRP A 117;ASP A 119;ASP A 120;PHE A 139","2GE A 201 (-4.0A);2GE A 201 ( 3.2A);2GE A 201 (-3.5A);2GE A 201 (-4.8A);2GE A 201 (-3.8A);2GE A 201 ( 4.9A);2GE A 201 (-3.9A);2GE A 201 (-2.8A);2GE A 201 (-2.9A);2GE A 201 ( 4.0A)","0.63A","4c9wA-5hzxA:27.9","4c9wA-5hzxA:62.86"]]