SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		4 / 7 LEU A 624
VAL A 620
TYR A 667
GLY A 631
 None
 1.02A 1lweA-5i08A:
undetectable		 1lweA-5i08A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
immunodeficiency
virus
1;
Human
coronavirus
HKU1) 		4 / 5 ASP A 389
VAL A 388
SER A 590
ASP A 417
 None
 1.45A 1n2xB-5i08A:
undetectable		 1n2xB-5i08A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		5 / 10 THR A 109
SER A 119
LEU A 146
VAL A 139
PHE A 200
 None
 1.47A 1q23E-5i08A:
undetectable		 1q23E-5i08A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		5 / 10 THR A 109
SER A 119
LEU A 146
VAL A 139
PHE A 200
 None
 1.46A 1q23K-5i08A:
undetectable		 1q23K-5i08A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		4 / 8 ASP A 623
GLY A 380
ASP A 606
TYR A 609
 None
 0.97A 1rmtC-5i08A:
undetectable		 1rmtC-5i08A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		5 / 12 PHE A 202
GLY A 101
ASN A  99
VAL A 125
TYR A 235
 None
 1.39A 2nyrB-5i08A:
undetectable		 2nyrB-5i08A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		5 / 12 VAL A 237
ILE A 124
PHE A 103
LEU A 261
PHE A  74
 None
 1.36A 3apwB-5i08A:
undetectable		 3apwB-5i08A:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		4 / 7 GLY A 302
ASP A 305
TYR A 304
ARG A 676
 None
 1.20A 3arrA-5i08A:
undetectable		 3arrA-5i08A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		4 / 7 GLY A 302
ASP A 305
TYR A 304
ARG A 676
 None
 1.19A 3aruA-5i08A:
undetectable		 3aruA-5i08A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		4 / 7 VAL A 363
ASP A 328
LEU A 359
ILE A 588
 None
 1.04A 3avpA-5i08A:
undetectable		 3avpA-5i08A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		4 / 5 LYS A 809
SER A 914
LEU A 850
SER A 806
 None
 1.43A 3ijxH-5i08A:
undetectable		 3ijxH-5i08A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		4 / 4 LYS A 809
SER A 914
LEU A 850
SER A 806
 None
 1.47A 3ik6H-5i08A:
undetectable		 3ik6H-5i08A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		4 / 5 LYS A 809
SER A 914
LEU A 850
SER A 806
 None
 1.45A 3iluH-5i08A:
undetectable		 3iluH-5i08A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		5 / 11 ALA A 962
ASN A 859
VAL A1134
ILE A1107
THR A 963
 None
 1.21A 3jw5A-5i08A:
undetectable		 3jw5A-5i08A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		4 / 5 LEU A1142
GLN A1016
GLU A 800
HIS A1145
 None
 0.98A 3n58C-5i08A:
undetectable		 3n58C-5i08A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		4 / 5 ASN A 722
ALA A 689
PRO A 688
TYR A 746
 None
 1.34A 3twpD-5i08A:
undetectable		 3twpD-5i08A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
immunodeficiency
virus
1;
Human
coronavirus
HKU1) 		5 / 12 ALA A1005
PHE A1146
ASN A1009
ILE A1130
VAL A 983
 None
 1.25A 4azsA-5i08A:
2.7		 4azsA-5i08A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		4 / 7 LEU A1141
LYS A1109
VAL A1114
LEU A 861
 None
 1.15A 4b3qA-5i08A:
undetectable		 4b3qA-5i08A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
immunodeficiency
virus
1;
Human
coronavirus
HKU1) 		4 / 8 THR A 959
THR A 805
LEU A 861
VAL A 857
 None
 1.13A 4l4dA-5i08A:
undetectable		 4l4dA-5i08A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
immunodeficiency
virus
1;
Human
coronavirus
HKU1) 		4 / 8 THR A 959
THR A 805
LEU A 861
VAL A 857
 None
 1.08A 4l4eA-5i08A:
undetectable		 4l4eA-5i08A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		5 / 11 ILE A 137
PHE A 209
SER A 104
ILE A 102
ILE A 126
 None
 1.31A 4p68A-5i08A:
undetectable		 4p68A-5i08A:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		4 / 7 TYR A 213
PHE A 202
SER A 122
LEU A 146
 None
 0.72A 4uymA-5i08A:
undetectable		 4uymA-5i08A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		5 / 12 LEU A 829
LEU A 843
PHE A 817
ALA A1084
LEU A1043
 None
 1.16A 5iepA-5i08A:
undetectable		 5iepA-5i08A:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
coronavirus
HKU1;
Human
immunodeficiency
virus
1) 		4 / 4 VAL A 216
LEU A  46
ASN A 108
ASP A 196
 None
 1.38A 5vcyA-5i08A:
undetectable		 5vcyA-5i08A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
immunodeficiency
virus
1;
Human
coronavirus
HKU1) 		3 / 3 ASP A 837
ASN A 840
ASP A 813
 None
 0.60A 5vopA-5i08A:
undetectable		 5vopA-5i08A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA
(Human
immunodeficiency
virus
1;
Human
coronavirus
HKU1) 		3 / 3 ASP A 837
ASN A 840
ASP A 813
 None
 0.66A 5vopB-5i08A:
undetectable		 5vopB-5i08A:
12.94