SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		5 / 12 GLY A 204
ALA A 332
SER A 235
HIS A 287
LEU A 291
 None
 1.20A 1kiaD-5i0pA:
undetectable		 1kiaD-5i0pA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		3 / 3 LEU A 246
LEU A 331
MET A 312
 None
 0.74A 1ya3B-5i0pA:
undetectable		 1ya3B-5i0pA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		4 / 7 GLU A  51
TRP A  58
ARG A  49
GLY A 193
 None
 1.21A 2hs1B-5i0pA:
undetectable		 2hs1B-5i0pA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		5 / 11 ASP A  98
HIS A  99
HIS A 205
ASP A 224
HIS A 269
 ZN  A 401 (-3.0A)
ZN  A 401 (-3.5A)
ZN  A 400 (-3.4A)
ZN  A 401 ( 2.2A)
ZN  A 401 (-3.5A)
 0.47A 2q0jB-5i0pA:
22.4		 2q0jB-5i0pA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		5 / 12 LEU A  47
VAL A  90
GLY A 101
ILE A  70
ILE A  60
 None
 0.97A 2r5pA-5i0pA:
undetectable		 2r5pA-5i0pA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		5 / 12 LEU A  47
VAL A  90
GLY A 101
ILE A  70
ILE A  60
 None
 0.97A 2r5pC-5i0pA:
undetectable		 2r5pC-5i0pA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		3 / 3 MET A 127
GLU A 208
ASP A 188
 None
 1.11A 3a25A-5i0pA:
undetectable		 3a25A-5i0pA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		3 / 3 ASN A 104
MET A 132
PHE A 100
 None
 1.01A 3g4lD-5i0pA:
undetectable		 3g4lD-5i0pA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		3 / 3 HIS A 286
ARG A 290
GLU A 329
 None
 0.69A 3qf1A-5i0pA:
undetectable		 3qf1A-5i0pA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		5 / 10 HIS A  94
HIS A  96
ASP A  98
HIS A 205
ASN A 233
 ZN  A 400 (-3.6A)
ZN  A 400 (-3.1A)
ZN  A 401 (-3.0A)
ZN  A 400 (-3.4A)
None
 1.03A 4c1dB-5i0pA:
19.5		 4c1dB-5i0pA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		5 / 10 HIS A  94
HIS A  96
ASP A  98
HIS A 205
HIS A 269
 ZN  A 400 (-3.6A)
ZN  A 400 (-3.1A)
ZN  A 401 (-3.0A)
ZN  A 400 (-3.4A)
ZN  A 401 (-3.5A)
 0.87A 4c1dB-5i0pA:
19.5		 4c1dB-5i0pA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		6 / 11 HIS A  94
HIS A  96
ASP A  98
HIS A 205
ASN A 233
HIS A 269
 ZN  A 400 (-3.6A)
ZN  A 400 (-3.1A)
ZN  A 401 (-3.0A)
ZN  A 400 (-3.4A)
None
ZN  A 401 (-3.5A)
 0.96A 4c1fA-5i0pA:
19.2
4c1fB-5i0pA:
19.0		 4c1fA-5i0pA:
19.29
4c1fB-5i0pA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		5 / 9 HIS A  94
HIS A  96
ASP A  98
ASN A 233
HIS A 269
 ZN  A 400 (-3.6A)
ZN  A 400 (-3.1A)
ZN  A 401 (-3.0A)
None
ZN  A 401 (-3.5A)
 0.69A 4c1hA-5i0pA:
19.5		 4c1hA-5i0pA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		5 / 9 HIS A  94
HIS A  96
ASP A  98
HIS A 205
HIS A 269
 ZN  A 400 (-3.6A)
ZN  A 400 (-3.1A)
ZN  A 401 (-3.0A)
ZN  A 400 (-3.4A)
ZN  A 401 (-3.5A)
 0.87A 4c1hA-5i0pA:
19.5		 4c1hA-5i0pA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		5 / 9 GLY A 101
ASP A  98
GLY A  64
VAL A  92
HIS A 269
 None
ZN  A 401 (-3.0A)
None
None
ZN  A 401 (-3.5A)
 1.19A 4c5lB-5i0pA:
undetectable		 4c5lB-5i0pA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		5 / 10 GLY A 101
ASP A  98
GLY A  64
HIS A  94
HIS A 269
 None
ZN  A 401 (-3.0A)
None
ZN  A 400 (-3.6A)
ZN  A 401 (-3.5A)
 1.07A 4c5nB-5i0pA:
undetectable		 4c5nB-5i0pA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		5 / 10 GLY A 101
ASP A  98
GLY A  64
VAL A  92
HIS A 269
 None
ZN  A 401 (-3.0A)
None
None
ZN  A 401 (-3.5A)
 1.21A 4c5nB-5i0pA:
undetectable		 4c5nB-5i0pA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		4 / 8 HIS A  96
ASP A  98
ASN A 233
HIS A 269
 ZN  A 400 (-3.1A)
ZN  A 401 (-3.0A)
None
ZN  A 401 (-3.5A)
 0.79A 4exsB-5i0pA:
18.1		 4exsB-5i0pA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		4 / 8 HIS A  96
ASP A  98
HIS A 205
HIS A 269
 ZN  A 400 (-3.1A)
ZN  A 401 (-3.0A)
ZN  A 400 (-3.4A)
ZN  A 401 (-3.5A)
 0.93A 4exsB-5i0pA:
18.1		 4exsB-5i0pA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		3 / 3 PRO A 267
ASN A  44
HIS A  42
 None
 0.85A 4ma3H-5i0pA:
undetectable
4ma3L-5i0pA:
undetectable		 4ma3H-5i0pA:
22.41
4ma3L-5i0pA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		4 / 5 GLY A 113
ARG A 114
GLU A  75
PHE A  78
 None
 1.14A 4r82A-5i0pA:
undetectable
4r82B-5i0pA:
undetectable		 4r82A-5i0pA:
20.91
4r82B-5i0pA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		4 / 6 PHE A 237
LYS A 324
GLY A 328
ALA A 332
 None
 1.00A 4yshB-5i0pA:
undetectable		 4yshB-5i0pA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		7 / 11 HIS A  94
HIS A  96
ASP A  98
HIS A  99
HIS A 205
THR A 232
HIS A 269
 ZN  A 400 (-3.6A)
ZN  A 400 (-3.1A)
ZN  A 401 (-3.0A)
ZN  A 401 (-3.5A)
ZN  A 400 (-3.4A)
None
ZN  A 401 (-3.5A)
 0.81A 5ayaA-5i0pA:
16.9		 5ayaA-5i0pA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		4 / 7 PHE A  12
ALA A  13
PRO A 272
LEU A  16
 None
 1.15A 5dzkD-5i0pA:
undetectable
5dzkR-5i0pA:
undetectable		 5dzkD-5i0pA:
21.04
5dzkR-5i0pA:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		4 / 6 CYH A 298
LEU A 343
HIS A 333
LEU A 334
 None
 1.16A 5hpuC-5i0pA:
undetectable
5hpuD-5i0pA:
undetectable		 5hpuC-5i0pA:
6.22
5hpuD-5i0pA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		4 / 6 HIS A 347
GLU A 242
ALA A 305
LEU A 327
 None
 1.10A 5igiA-5i0pA:
undetectable		 5igiA-5i0pA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		4 / 6 ASP A  98
HIS A  99
HIS A  94
LEU A  40
 ZN  A 401 (-3.0A)
ZN  A 401 (-3.5A)
ZN  A 400 (-3.6A)
None
 1.09A 5nelB-5i0pA:
undetectable
5nelC-5i0pA:
undetectable		 5nelB-5i0pA:
19.79
5nelC-5i0pA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		4 / 6 HIS A 205
HIS A  94
LEU A  40
HIS A 269
 ZN  A 400 (-3.4A)
ZN  A 400 (-3.6A)
None
ZN  A 401 (-3.5A)
 0.95A 5nelB-5i0pA:
undetectable
5nelC-5i0pA:
undetectable		 5nelB-5i0pA:
19.79
5nelC-5i0pA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		4 / 5 LEU A 220
MET A 225
CYH A 210
ASP A  62
 None
 1.43A 5p9iA-5i0pA:
undetectable		 5p9iA-5i0pA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		4 / 8 HIS A  96
ASP A  98
HIS A 205
HIS A 269
 ZN  A 400 (-3.1A)
ZN  A 401 (-3.0A)
ZN  A 400 (-3.4A)
ZN  A 401 (-3.5A)
 1.00A 5zj8A-5i0pA:
18.1		 5zj8A-5i0pA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		3 / 3 HIS A 152
ARG A 345
ILE A 353
 None
 0.80A 6fgdA-5i0pA:
undetectable		 6fgdA-5i0pA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		3 / 3 ARG A 279
LYS A   5
TYR A  10
 None
 1.32A 6gnaA-5i0pA:
undetectable		 6gnaA-5i0pA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5i0p BETA-LACTAMASE
DOMAIN PROTEIN
(Burkholderia
ambifaria) 		3 / 3 ARG A 279
LYS A   5
TYR A  10
 None
 1.32A 6gnbA-5i0pA:
undetectable		 6gnbA-5i0pA:
22.19