SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 5i10 PROBABLE
O-METHYLTRANSFERASE
(Saccharopolyspor
a
spinosa) 		4 / 6 ILE A 236
LYS A 224
ALA A 222
MET A 193
 None
 1.09A 1hk2A-5i10A:
undetectable		 1hk2A-5i10A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5i10 PROBABLE
O-METHYLTRANSFERASE
(Saccharopolyspor
a
spinosa) 		3 / 3 GLU A  81
THR A  82
LEU A 179
 None
 0.67A 1v8bC-5i10A:
2.0		 1v8bC-5i10A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 5i10 PROBABLE
O-METHYLTRANSFERASE
(Saccharopolyspor
a
spinosa) 		5 / 12 PHE A 162
GLY A  87
GLY A  88
LEU A  16
LEU A 156
 None
 1.06A 1ya4C-5i10A:
undetectable		 1ya4C-5i10A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ATT_A_ACTA1209_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5i10 PROBABLE
O-METHYLTRANSFERASE
(Saccharopolyspor
a
spinosa) 		4 / 4 ASP A 212
ARG A  59
ASP A 185
GLU A  81
 MG  A 301 (-3.4A)
None
MG  A 301 (-3.5A)
None
 1.30A 3attA-5i10A:
0.3		 3attA-5i10A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5i10 PROBABLE
O-METHYLTRANSFERASE
(Saccharopolyspor
a
spinosa) 		4 / 8 GLY A  87
TYR A   8
LEU A  12
VAL A  15
 None
 0.90A 4fgzB-5i10A:
10.5		 4fgzB-5i10A:
18.37