SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5i14 MUTATED AND
TRUNCATED T4
LYSOZYME
(Escherichia
virus
T4) 		5 / 12 ALA A  86
PHE A 110
LEU A  90
ALA A  87
ILE A  35
 None
 0.93A 2aclA-5i14A:
undetectable
2aclE-5i14A:
undetectable		 2aclA-5i14A:
19.67
2aclE-5i14A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5i14 MUTATED AND
TRUNCATED T4
LYSOZYME
(Escherichia
virus
T4) 		4 / 6 PHE A 110
VAL A  44
LEU A  75
ALA A  86
 None
 0.98A 2e1qA-5i14A:
undetectable		 2e1qA-5i14A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5i14 MUTATED AND
TRUNCATED T4
LYSOZYME
(Escherichia
virus
T4) 		4 / 6 PHE A 110
VAL A  44
LEU A  75
ALA A  86
 None
 0.97A 2e1qC-5i14A:
undetectable		 2e1qC-5i14A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5i14 MUTATED AND
TRUNCATED T4
LYSOZYME
(Escherichia
virus
T4) 		5 / 12 MET A  59
PHE A  71
ALA A  69
PHE A 110
GLY A  34
 None
 1.46A 3aobC-5i14A:
undetectable		 3aobC-5i14A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5i14 MUTATED AND
TRUNCATED T4
LYSOZYME
(Escherichia
virus
T4) 		5 / 10 ALA A  86
PHE A 110
LEU A  90
ALA A  87
ILE A  35
 None
 0.99A 3falC-5i14A:
undetectable		 3falC-5i14A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5i14 MUTATED AND
TRUNCATED T4
LYSOZYME
(Escherichia
virus
T4) 		5 / 11 ALA A  86
PHE A 110
LEU A  90
ALA A  87
ILE A  35
 None
 0.96A 3fc6A-5i14A:
undetectable		 3fc6A-5i14A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5i14 MUTATED AND
TRUNCATED T4
LYSOZYME
(Escherichia
virus
T4) 		5 / 9 LEU A  90
LEU A  78
ILE A  35
PHE A  71
VAL A  68
 None
 1.44A 3tmzA-5i14A:
undetectable		 3tmzA-5i14A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5i14 MUTATED AND
TRUNCATED T4
LYSOZYME
(Escherichia
virus
T4) 		4 / 7 PHE A 110
VAL A  44
LEU A  75
ALA A  86
 None
 0.97A 3uniA-5i14A:
undetectable		 3uniA-5i14A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5i14 MUTATED AND
TRUNCATED T4
LYSOZYME
(Escherichia
virus
T4) 		5 / 12 ALA A  86
PHE A 110
LEU A  90
ALA A  87
ILE A  35
 None
 0.96A 6a5zL-5i14A:
undetectable		 6a5zL-5i14A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 5i14 MUTATED AND
TRUNCATED T4
LYSOZYME
(Escherichia
virus
T4) 		4 / 4 ILE A 107
LEU A  78
HIS A  89
ALA A  77
 None
None
NI  A 202 (-3.2A)
None
 1.05A 6ck2C-5i14A:
undetectable
6ck2D-5i14A:
undetectable		 6ck2C-5i14A:
13.79
6ck2D-5i14A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5i14 MUTATED AND
TRUNCATED T4
LYSOZYME
(Escherichia
virus
T4) 		3 / 3 HIS A  73
HIS A  85
HIS A  89
 NI  A 202 (-3.3A)
NI  A 202 (-3.3A)
NI  A 202 (-3.2A)
 0.75A 6giqa-5i14A:
undetectable		 6giqa-5i14A:
12.85