SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		5 / 12 ILE A 236
ILE A 309
LEU A 279
ILE A 252
PHE A 304
 None
 1.14A 1bsxA-5i1tA:
undetectable		 1bsxA-5i1tA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		5 / 12 ILE A 236
ILE A 309
LEU A 279
ILE A 252
PHE A 304
 None
 1.14A 1bsxB-5i1tA:
undetectable		 1bsxB-5i1tA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		5 / 10 LEU A 191
VAL A 320
TYR A 121
GLY A 321
TYR A 213
 CTO  A 404 (-4.7A)
None
CTO  A 404 (-4.4A)
None
CTO  A 404 (-4.6A)
 1.38A 1ikwA-5i1tA:
undetectable		 1ikwA-5i1tA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		5 / 12 THR A 285
LEU A 284
ASN A 281
PHE A 300
LEU A 245
 None
 1.03A 1wsvA-5i1tA:
undetectable		 1wsvA-5i1tA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		3 / 3 LEU A 191
HIS A 128
LYS A 125
 CTO  A 404 (-4.7A)
None
CTO  A 404 ( 4.9A)
 1.05A 1y7iA-5i1tA:
undetectable		 1y7iA-5i1tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		4 / 8 TYR A 308
ASN A 238
GLU A 306
GLY A 307
 None
 1.07A 1ykiA-5i1tA:
undetectable
1ykiB-5i1tA:
undetectable		 1ykiA-5i1tA:
21.28
1ykiB-5i1tA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		4 / 8 TYR A 308
ASN A 238
GLU A 306
GLY A 307
 None
 1.06A 1ykiC-5i1tA:
undetectable
1ykiD-5i1tA:
undetectable		 1ykiC-5i1tA:
21.28
1ykiD-5i1tA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		4 / 7 ALA A 117
TYR A 194
TYR A 124
TYR A 213
 None
CTO  A 404 (-3.5A)
None
CTO  A 404 (-4.6A)
 1.18A 2ajvH-5i1tA:
undetectable
2ajvL-5i1tA:
undetectable		 2ajvH-5i1tA:
21.35
2ajvL-5i1tA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		4 / 8 MET A 330
ASP A 224
SER A 323
HIS A 343
 None
 1.24A 2bteA-5i1tA:
undetectable		 2bteA-5i1tA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		4 / 7 LEU A 279
PHE A 241
ILE A 289
PHE A 300
 None
 0.96A 2opxA-5i1tA:
undetectable		 2opxA-5i1tA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		5 / 11 LEU A  98
ALA A 110
ALA A 327
TYR A 194
GLN A 147
 None
None
None
CTO  A 404 (-3.5A)
None
 1.50A 3bszF-5i1tA:
undetectable		 3bszF-5i1tA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HVT_A_NVPA557_1
(HIV-1 REVERSE
TRANSCRIPTASE
(SUBUNIT P66))		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		5 / 9 LEU A 191
VAL A 320
TYR A 121
GLY A 321
TYR A 213
 CTO  A 404 (-4.7A)
None
CTO  A 404 (-4.4A)
None
CTO  A 404 (-4.6A)
 1.33A 3hvtA-5i1tA:
undetectable		 3hvtA-5i1tA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		5 / 12 ILE A 236
ILE A 309
LEU A 279
ILE A 252
PHE A 304
 None
 1.12A 3uvvA-5i1tA:
undetectable		 3uvvA-5i1tA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		4 / 6 THR A 202
GLY A 200
PRO A 222
GLY A 329
 None
None
GOL  A 406 ( 4.9A)
None
 0.90A 4fjpA-5i1tA:
undetectable		 4fjpA-5i1tA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		4 / 9 CYH A 146
HIS A  80
ILE A  75
MET A  88
 ZN  A 401 ( 2.3A)
None
None
None
 1.23A 4jvlA-5i1tA:
undetectable		 4jvlA-5i1tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		4 / 8 VAL A 292
PHE A 241
ILE A 254
VAL A 263
 None
 0.84A 5nujA-5i1tA:
undetectable		 5nujA-5i1tA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		5 / 12 LEU A 284
VAL A 263
GLY A 280
ASN A 281
ILE A 254
 None
 0.86A 5vopA-5i1tA:
undetectable		 5vopA-5i1tA:
20.82