SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5i1u GERMACRADIEN-4-OL
SYNTHASE
(Streptomyces
citricolor) 		5 / 9 GLN A 259
MET A   1
SER A 308
GLU A   8
ALA A 262
 None
 1.39A 1wrlA-5i1uA:
undetectable
1wrlB-5i1uA:
undetectable		 1wrlA-5i1uA:
15.28
1wrlB-5i1uA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5i1u GERMACRADIEN-4-OL
SYNTHASE
(Streptomyces
citricolor) 		3 / 3 PHE A 216
ARG A 240
ASN A 234
 None
 0.86A 1xzxX-5i1uA:
undetectable		 1xzxX-5i1uA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5i1u GERMACRADIEN-4-OL
SYNTHASE
(Streptomyces
citricolor) 		3 / 3 ARG A  90
GLY A  88
SER A 116
 None
 0.64A 2xctB-5i1uA:
3.2		 2xctB-5i1uA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5i1u GERMACRADIEN-4-OL
SYNTHASE
(Streptomyces
citricolor) 		4 / 8 ARG A 172
LEU A 171
TYR A 146
HIS A 150
 None
 1.27A 3zmdA-5i1uA:
undetectable
3zmdB-5i1uA:
undetectable		 3zmdA-5i1uA:
23.30
3zmdB-5i1uA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5i1u GERMACRADIEN-4-OL
SYNTHASE
(Streptomyces
citricolor) 		4 / 5 VAL A 220
ARG A 221
GLU A 307
LEU A   7
 None
 1.43A 4hojA-5i1uA:
undetectable		 4hojA-5i1uA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 5i1u GERMACRADIEN-4-OL
SYNTHASE
(Streptomyces
citricolor) 		3 / 3 VAL A  40
SER A  41
THR A  44
 None
 0.44A 4luhA-5i1uA:
2.0		 4luhA-5i1uA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5i1u GERMACRADIEN-4-OL
SYNTHASE
(Streptomyces
citricolor) 		4 / 9 ILE A 185
PHE A 182
VAL A 193
ASP A 294
 None
 1.07A 5lg3I-5i1uA:
4.3		 5lg3I-5i1uA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5i1u GERMACRADIEN-4-OL
SYNTHASE
(Streptomyces
citricolor) 		3 / 3 TYR A 303
SER A 215
TRP A 299
 None
 1.08A 5n8jB-5i1uA:
undetectable		 5n8jB-5i1uA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 5i1u GERMACRADIEN-4-OL
SYNTHASE
(Streptomyces
citricolor) 		5 / 11 TYR A 168
ASP A 212
THR A 175
GLY A 174
GLU A 179
 None
 1.50A 6mb5A-5i1uA:
undetectable		 6mb5A-5i1uA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5i1u GERMACRADIEN-4-OL
SYNTHASE
(Streptomyces
citricolor) 		4 / 8 TRP A 124
ASP A 122
HIS A  33
GLU A  64
 None
 1.27A 6mn4C-5i1uA:
undetectable		 6mn4C-5i1uA:
20.62