SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		5 / 12 TYR A  99
LEU A 250
SER A  18
LEU A 243
ILE A 274
 OLC  A 301 ( 4.8A)
None
None
None
None
 1.39A 1fmlA-5i20A:
undetectable		 1fmlA-5i20A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		5 / 10 PHE A 225
TYR A 166
LEU A  75
THR A  39
TYR A 226
 None
 1.35A 1rmtA-5i20A:
undetectable		 1rmtA-5i20A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 7 VAL A 242
TYR A  99
TYR A 245
ILE A 105
 None
OLC  A 301 ( 4.8A)
None
None
 1.28A 2xz5B-5i20A:
undetectable
2xz5E-5i20A:
undetectable		 2xz5B-5i20A:
19.67
2xz5E-5i20A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 8 ILE A 105
VAL A 242
TYR A  99
TYR A 245
 None
None
OLC  A 301 ( 4.8A)
None
 1.27A 2xz5A-5i20A:
undetectable
2xz5C-5i20A:
undetectable		 2xz5A-5i20A:
19.67
2xz5C-5i20A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 8 ILE A 105
VAL A 242
TYR A  99
TYR A 245
 None
None
OLC  A 301 ( 4.8A)
None
 1.28A 2xz5C-5i20A:
undetectable
2xz5D-5i20A:
undetectable		 2xz5C-5i20A:
19.67
2xz5D-5i20A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 7 ILE A 105
VAL A 242
TYR A  99
TYR A 245
 None
None
OLC  A 301 ( 4.8A)
None
 1.27A 2xz5D-5i20A:
undetectable
2xz5E-5i20A:
undetectable		 2xz5D-5i20A:
19.67
2xz5E-5i20A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		5 / 11 GLY A 277
ALA A 278
LEU A 129
PRO A 248
VAL A 249
 None
 0.88A 3em4U-5i20A:
undetectable		 3em4U-5i20A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		6 / 11 ALA A 123
HIS A 121
VAL A 280
VAL A 242
GLY A 128
ALA A 130
 None
 1.49A 3sm2B-5i20A:
undetectable		 3sm2B-5i20A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		3 / 3 TRP A 101
VAL A 161
TRP A 163
 OLC  A 301 (-3.8A)
None
OLC  A 301 (-3.8A)
 1.50A 3zq8A-5i20A:
undetectable
3zq8B-5i20A:
undetectable		 3zq8A-5i20A:
5.70
3zq8B-5i20A:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		5 / 11 TYR A  78
GLY A  71
TYR A 166
TRP A 163
TYR A 226
 OLC  A 301 (-4.3A)
None
None
OLC  A 301 (-3.8A)
None
 1.47A 4ey7A-5i20A:
undetectable		 4ey7A-5i20A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		5 / 11 TYR A  78
GLY A  71
TYR A 166
TRP A 163
TYR A 226
 OLC  A 301 (-4.3A)
None
None
OLC  A 301 (-3.8A)
None
 1.48A 4ey7B-5i20A:
undetectable		 4ey7B-5i20A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		5 / 12 ILE A 223
GLY A  44
GLY A  47
ILE A  42
PHE A 184
 None
 0.99A 4kicB-5i20A:
undetectable		 4kicB-5i20A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 7 ALA A 246
GLY A 277
ALA A 278
THR A 282
 None
None
None
OLC  A 302 ( 4.4A)
 0.81A 4r1zB-5i20A:
undetectable		 4r1zB-5i20A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		5 / 9 ALA A 246
GLY A 277
ALA A 278
THR A 282
ILE A  14
 None
None
None
OLC  A 302 ( 4.4A)
None
 0.93A 4r21B-5i20A:
undetectable		 4r21B-5i20A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		5 / 12 GLY A 217
GLY A  43
GLY A  44
ALA A 212
LEU A  35
 None
 0.93A 5c0oF-5i20A:
undetectable		 5c0oF-5i20A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 6 SER A 170
GLY A 231
ILE A 105
TRP A 228
 None
 1.14A 5j4nA-5i20A:
undetectable		 5j4nA-5i20A:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 8 PRO A 248
ALA A 125
THR A 132
ALA A  98
 None
None
None
OLC  A 301 ( 3.7A)
 0.95A 5x2tI-5i20A:
undetectable
5x2tJ-5i20A:
undetectable
5x2tK-5i20A:
undetectable
5x2tL-5i20A:
undetectable		 5x2tI-5i20A:
18.79
5x2tJ-5i20A:
21.67
5x2tK-5i20A:
18.79
5x2tL-5i20A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 6 GLY A 231
ASP A 229
SER A 170
ARG A 171
 None
 1.04A 6dwdA-5i20A:
undetectable
6dwdC-5i20A:
undetectable		 6dwdA-5i20A:
20.59
6dwdC-5i20A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 6 LEU A 186
THR A  41
CYH A 185
GLY A  43
 None
 1.27A 6gtqB-5i20A:
undetectable
6gtqD-5i20A:
undetectable		 6gtqB-5i20A:
20.46
6gtqD-5i20A:
11.57