SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		5 / 10 HIS A 135
VAL A 139
LEU A  85
LEU A  80
THR A  78
 None
 1.19A 1rj6A-5i2bA:
undetectable		 1rj6A-5i2bA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		5 / 10 HIS A 135
VAL A 139
LEU A  85
LEU A  80
THR A  78
 None
 1.22A 1rj6B-5i2bA:
undetectable		 1rj6B-5i2bA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		5 / 12 PRO A 152
GLY A 162
PHE A 161
GLY A  98
TYR A 151
 None
None
None
BB2  A 202 (-2.7A)
None
 1.17A 4lxzA-5i2bA:
undetectable		 4lxzA-5i2bA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		5 / 12 PRO A 152
GLY A 162
PHE A 161
GLY A  98
TYR A 151
 None
None
None
BB2  A 202 (-2.7A)
None
 1.15A 4lxzC-5i2bA:
undetectable		 4lxzC-5i2bA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		4 / 8 HIS A 145
GLU A 142
ASP A 144
ARG A 154
 ZN  A 201 ( 3.5A)
BB2  A 202 (-2.2A)
EDO  A 203 ( 4.8A)
EDO  A 203 (-2.8A)
 1.17A 4uhxA-5i2bA:
undetectable		 4uhxA-5i2bA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		4 / 8 HIS A 145
GLU A 142
ASP A 144
ARG A 154
 ZN  A 201 ( 3.5A)
BB2  A 202 (-2.2A)
EDO  A 203 ( 4.8A)
EDO  A 203 (-2.8A)
 1.17A 4uhxA-5i2bA:
undetectable		 4uhxA-5i2bA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		5 / 12 PRO A 152
GLY A 162
PHE A 161
PHE A 163
TYR A 151
 None
 1.44A 5eeiA-5i2bA:
undetectable		 5eeiA-5i2bA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		5 / 12 PRO A 152
GLY A 162
PHE A 161
PHE A 163
TYR A 151
 None
 1.44A 5eeiB-5i2bA:
undetectable		 5eeiB-5i2bA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		3 / 3 GLU A 142
HIS A 141
ARG A 137
 BB2  A 202 (-2.2A)
BB2  A 202 ( 2.4A)
None
 0.93A 5uunA-5i2bA:
undetectable		 5uunA-5i2bA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		4 / 5 PRO A  83
GLY A 119
TYR A 117
VAL A  79
 None
None
None
EDO  A 207 ( 4.3A)
 1.43A 5x80C-5i2bA:
undetectable
5x80D-5i2bA:
undetectable		 5x80C-5i2bA:
24.75
5x80D-5i2bA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		3 / 3 HIS A 145
HIS A 141
ARG A 111
 ZN  A 201 ( 3.5A)
BB2  A 202 ( 2.4A)
EDO  A 203 ( 4.7A)
 1.13A 6b58A-5i2bA:
undetectable		 6b58A-5i2bA:
17.71