SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5i2c GATS-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 LEU A  13
LEU A  69
VAL A  15
VAL A  55
LEU A  30
 None
 1.26A 1ie9A-5i2cA:
undetectable		 1ie9A-5i2cA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5i2c GATS-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 11 VAL A  71
PHE A  60
LEU A  63
PRO A  65
TYR A  23
 None
 1.23A 1klmA-5i2cA:
undetectable		 1klmA-5i2cA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5i2c GATS-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 LEU A 113
ALA A  72
GLN A  70
HIS A 175
ILE A 280
 ARG  A 401 ( 4.9A)
None
None
None
ARG  A 401 (-3.9A)
 1.01A 2jn3A-5i2cA:
undetectable		 2jn3A-5i2cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5i2c GATS-LIKE PROTEIN 3
(Homo
sapiens) 		3 / 3 ASP A 121
PHE A 122
LEU A 124
 None
 0.65A 2zi9A-5i2cA:
undetectable		 2zi9A-5i2cA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5i2c GATS-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 SER A 208
PHE A 228
CYH A 185
PHE A 184
 None
 0.94A 3m0wE-5i2cA:
undetectable
3m0wF-5i2cA:
undetectable
3m0wG-5i2cA:
undetectable
3m0wH-5i2cA:
undetectable		 3m0wE-5i2cA:
14.89
3m0wF-5i2cA:
14.89
3m0wG-5i2cA:
14.89
3m0wH-5i2cA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 5i2c GATS-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 VAL A  71
PHE A  60
LEU A  63
PRO A  65
TYR A  23
 None
 1.25A 3mecA-5i2cA:
undetectable		 3mecA-5i2cA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5i2c GATS-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 VAL A 133
LEU A 137
ILE A 123
MET A 114
 None
 0.83A 3u5kA-5i2cA:
undetectable		 3u5kA-5i2cA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5i2c GATS-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 VAL A 133
LEU A 137
ILE A 123
MET A 114
 None
 0.78A 3u5kC-5i2cA:
undetectable		 3u5kC-5i2cA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 5i2c GATS-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 5 LEU A  33
PHE A  32
PRO A 195
ALA A 198
 None
 0.73A 3vm4A-5i2cA:
undetectable		 3vm4A-5i2cA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 5i2c GATS-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 5 GLU A 234
HIS A   8
LEU A  79
VAL A  78
 None
 1.12A 6bc9A-5i2cA:
undetectable		 6bc9A-5i2cA:
13.40