SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 11 GLU A 440
GLY A 437
GLU A 527
LEU A 276
HIS A 283
 PGO  A 901 (-2.8A)
PGO  A 901 (-3.3A)
None
None
PGO  A 901 (-4.0A)
 1.46A 1mjqA-5i2gA:
0.1
1mjqB-5i2gA:
undetectable		 1mjqA-5i2gA:
10.49
1mjqB-5i2gA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 4 GLY A 165
VAL A 167
TRP A 450
GLY A 449
 None
 1.42A 1ng8A-5i2gA:
undetectable		 1ng8A-5i2gA:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 4 GLY A 165
VAL A 167
TRP A 450
GLY A 449
 None
 1.42A 1ng8B-5i2gA:
undetectable		 1ng8B-5i2gA:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 6 GLN A 263
VAL A 254
ALA A 259
SER A 261
 None
 0.98A 1p6kA-5i2gA:
undetectable		 1p6kA-5i2gA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 12 ILE A 558
GLY A 724
PRO A 725
TYR A 780
HIS A 746
 None
 1.45A 1s9aB-5i2gA:
undetectable		 1s9aB-5i2gA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 12 LEU A 315
ILE A 316
ILE A 319
LEU A 363
LEU A 307
 None
 0.91A 1xdkB-5i2gA:
1.4		 1xdkB-5i2gA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 8 PHE A 492
LEU A 462
LEU A 587
LEU A 583
 None
 1.01A 2bfpA-5i2gA:
undetectable		 2bfpA-5i2gA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		3 / 3 LYS A 835
ASP A 711
CYH A 459
 None
 1.07A 2br4F-5i2gA:
undetectable		 2br4F-5i2gA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 6 ALA A 312
TYR A 298
ILE A 316
ILE A   9
 None
 1.19A 2dcfA-5i2gA:
undetectable		 2dcfA-5i2gA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 7 GLN A 690
TYR A 689
TYR A 159
ILE A 514
 None
 1.02A 2ph9A-5i2gA:
undetectable
2ph9B-5i2gA:
undetectable		 2ph9A-5i2gA:
14.35
2ph9B-5i2gA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 7 TYR A 433
VAL A 439
TYR A 411
ILE A 436
 None
 1.32A 2xz5B-5i2gA:
undetectable
2xz5E-5i2gA:
undetectable		 2xz5B-5i2gA:
13.94
2xz5E-5i2gA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 8 TYR A 293
SER A 364
CYH A 367
ILE A 316
 None
 1.17A 2xz5B-5i2gA:
undetectable
2xz5E-5i2gA:
undetectable		 2xz5B-5i2gA:
13.94
2xz5E-5i2gA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 7 ILE A 436
TYR A 433
VAL A 439
TYR A 411
 None
 1.34A 2xz5D-5i2gA:
undetectable
2xz5E-5i2gA:
undetectable		 2xz5D-5i2gA:
13.94
2xz5E-5i2gA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 7 ALA A 312
TYR A 298
ILE A 316
ILE A   9
 None
 1.19A 2zm7A-5i2gA:
undetectable		 2zm7A-5i2gA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 6 GLN A 554
GLY A 692
HIS A 166
CYH A 438
 None
None
PGO  A 901 (-4.0A)
PGO  A 901 (-3.6A)
 1.40A 3ai8B-5i2gA:
undetectable		 3ai8B-5i2gA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 10 VAL A 349
ALA A 359
ILE A 416
ILE A 348
THR A 360
 None
 1.10A 3clbD-5i2gA:
undetectable		 3clbD-5i2gA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 12 LEU A 530
PHE A 271
GLN A 267
VAL A 182
ILE A 218
 None
 1.13A 3gwxB-5i2gA:
undetectable		 3gwxB-5i2gA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		3 / 3 MET A 294
CYH A 367
PRO A 287
 None
 1.26A 3h52C-5i2gA:
undetectable		 3h52C-5i2gA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 10 VAL A 349
ALA A 359
ILE A 416
ILE A 348
THR A 360
 None
 1.09A 3hbbD-5i2gA:
undetectable		 3hbbD-5i2gA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		3 / 3 ASP A 745
ARG A 668
ARG A 423
 None
 0.81A 3k37A-5i2gA:
undetectable		 3k37A-5i2gA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 10 ILE A 777
PHE A 773
ILE A 774
ILE A 383
SER A 382
 None
 1.15A 3o1cA-5i2gA:
undetectable		 3o1cA-5i2gA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 7 ALA A 419
PRO A 418
TYR A 433
ARG A 431
 None
 1.08A 3twpC-5i2gA:
undetectable		 3twpC-5i2gA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 9 ALA A 546
ASP A 532
GLY A 538
PRO A 525
LEU A 524
 None
 1.23A 3u7sB-5i2gA:
undetectable		 3u7sB-5i2gA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 12 LEU A 394
GLY A 351
ILE A 383
ILE A 348
ARG A 431
 None
 1.18A 3uj7A-5i2gA:
undetectable		 3uj7A-5i2gA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 12 CYH A 529
LEU A 530
LEU A 179
ASN A 180
ILE A 210
 None
 1.16A 3ut5B-5i2gA:
2.0		 3ut5B-5i2gA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 5 LEU A 744
LEU A 693
MET A 458
THR A 675
 None
 1.42A 4do3A-5i2gA:
undetectable		 4do3A-5i2gA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 7 TYR A  23
ILE A 812
THR A 824
GLY A 340
 None
 0.94A 4eqlA-5i2gA:
undetectable		 4eqlA-5i2gA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 7 TYR A  23
ILE A 812
THR A 824
GLY A 340
 None
 0.89A 4eqlB-5i2gA:
undetectable		 4eqlB-5i2gA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 12 GLY A  76
TYR A 220
ILE A  68
VAL A 321
ILE A  74
 None
 1.18A 4fglA-5i2gA:
undetectable
4fglB-5i2gA:
undetectable		 4fglA-5i2gA:
13.74
4fglB-5i2gA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 8 ILE A 568
ALA A 670
PRO A 710
VAL A 465
 None
 0.79A 4jltA-5i2gA:
undetectable		 4jltA-5i2gA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 6 TYR A  23
ILE A 812
THR A 824
GLY A 340
 None
 0.92A 4l39A-5i2gA:
undetectable		 4l39A-5i2gA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 7 TYR A  23
ILE A 812
THR A 824
GLY A 340
 None
 0.92A 4l39B-5i2gA:
undetectable		 4l39B-5i2gA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 9 THR A 753
LEU A 693
ALA A 749
LEU A 678
TYR A 672
 None
 1.30A 4ltwA-5i2gA:
undetectable		 4ltwA-5i2gA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 4 ASN A 756
SER A 819
ALA A 816
VAL A 696
 None
None
None
PGO  A 901 (-4.3A)
 1.16A 4x1kC-5i2gA:
undetectable		 4x1kC-5i2gA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 12 PHE A 492
ILE A 650
PHE A 489
LEU A 565
LEU A 462
 None
 1.29A 4xumA-5i2gA:
undetectable		 4xumA-5i2gA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 12 ALA A 671
LEU A 744
THR A 753
GLY A 557
ALA A 562
 None
 1.19A 4ypmA-5i2gA:
undetectable		 4ypmA-5i2gA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		3 / 3 ASP A 362
GLU A 310
SER A 390
 None
 0.70A 5bw4B-5i2gA:
undetectable		 5bw4B-5i2gA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 12 PRO A 718
GLY A 557
GLY A 703
LEU A 702
ALA A 562
 None
 0.96A 5c0oE-5i2gA:
undetectable		 5c0oE-5i2gA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 9 HIS A 283
GLY A 163
GLY A 282
ASP A 452
HIS A 166
 PGO  A 901 (-4.0A)
None
None
PGO  A 901 (-3.5A)
PGO  A 901 (-4.0A)
 1.40A 5f8yA-5i2gA:
undetectable		 5f8yA-5i2gA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 8 HIS A 283
GLY A 163
GLY A 282
ASP A 452
HIS A 166
 PGO  A 901 (-4.0A)
None
None
PGO  A 901 (-3.5A)
PGO  A 901 (-4.0A)
 1.45A 5f8yA-5i2gA:
undetectable		 5f8yA-5i2gA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 9 HIS A 283
GLY A 163
GLY A 282
ASP A 452
HIS A 166
 PGO  A 901 (-4.0A)
None
None
PGO  A 901 (-3.5A)
PGO  A 901 (-4.0A)
 1.44A 5f8yA-5i2gA:
undetectable		 5f8yA-5i2gA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 8 HIS A 283
GLY A 163
GLY A 282
ASP A 452
HIS A 166
 PGO  A 901 (-4.0A)
None
None
PGO  A 901 (-3.5A)
PGO  A 901 (-4.0A)
 1.49A 5f8yB-5i2gA:
undetectable		 5f8yB-5i2gA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 9 HIS A 283
GLY A 163
GLY A 282
ASP A 452
HIS A 166
 PGO  A 901 (-4.0A)
None
None
PGO  A 901 (-3.5A)
PGO  A 901 (-4.0A)
 1.41A 5f8yB-5i2gA:
undetectable		 5f8yB-5i2gA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 12 LEU A 829
GLY A 337
VAL A 700
PHE A 344
SER A 380
 None
None
None
PGO  A 901 (-3.4A)
None
 1.04A 5f9zA-5i2gA:
undetectable		 5f9zA-5i2gA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 12 ALA A 126
PRO A  89
SER A  40
THR A  44
GLU A  35
 None
 1.17A 5hfjD-5i2gA:
undetectable		 5hfjD-5i2gA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 4 ARG A 778
ILE A 777
TYR A 410
ILE A 383
 None
 1.29A 5odhG-5i2gA:
undetectable		 5odhG-5i2gA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		5 / 12 GLN A 442
PHE A 550
ASP A 448
SER A 286
ILE A 285
 None
 1.37A 5uacC-5i2gA:
undetectable		 5uacC-5i2gA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 5 ASP A 800
PRO A 761
GLU A 838
ARG A 795
 None
 1.29A 5uxcA-5i2gA:
1.3		 5uxcA-5i2gA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5i2g DIOL DEHYDRATASE
(Roseburia
inulinivorans) 		4 / 8 GLY A 785
GLN A 352
VAL A 415
TYR A 411
 None
 1.05A 5vlmA-5i2gA:
2.2		 5vlmA-5i2gA:
14.04