SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i2q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		5 / 11 LEU A 117
MET A 121
LEU A 124
MET A 136
VAL A 140
 None
 0.77A 1dtlA-5i2qA:
11.0		 1dtlA-5i2qA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		6 / 12 ILE A 112
LEU A 117
MET A 121
LEU A 124
MET A 136
ILE A 137
 None
 1.13A 1lxfC-5i2qA:
9.9		 1lxfC-5i2qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 7 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.82A 1v54N-5i2qA:
undetectable
1v54W-5i2qA:
undetectable		 1v54N-5i2qA:
11.61
1v54W-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 7 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.82A 2dyrN-5i2qA:
undetectable
2dyrW-5i2qA:
undetectable		 2dyrN-5i2qA:
11.61
2dyrW-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 8 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.84A 2eijN-5i2qA:
undetectable
2eijW-5i2qA:
undetectable		 2eijN-5i2qA:
11.61
2eijW-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 8 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.82A 2eikN-5i2qA:
undetectable
2eikW-5i2qA:
undetectable		 2eikN-5i2qA:
11.61
2eikW-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 8 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.83A 2eilN-5i2qA:
undetectable
2eilW-5i2qA:
undetectable		 2eilN-5i2qA:
11.61
2eilW-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 8 LEU A 174
LEU A 171
LYS A 159
ALA A 160
 None
 1.04A 2wekA-5i2qA:
undetectable		 2wekA-5i2qA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 7 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.84A 3ablA-5i2qA:
undetectable
3ablJ-5i2qA:
undetectable		 3ablA-5i2qA:
11.61
3ablJ-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 8 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.89A 3ablN-5i2qA:
undetectable
3ablW-5i2qA:
undetectable		 3ablN-5i2qA:
11.61
3ablW-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 8 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.87A 3ag3N-5i2qA:
undetectable
3ag3W-5i2qA:
undetectable		 3ag3N-5i2qA:
11.61
3ag3W-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 8 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.84A 3asnN-5i2qA:
undetectable
3asnW-5i2qA:
undetectable		 3asnN-5i2qA:
11.61
3asnW-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 6 LEU A 148
SER A 149
PHE A 153
ILE A 156
 None
 0.90A 3ko0B-5i2qA:
7.4		 3ko0B-5i2qA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		5 / 12 LEU A 148
SER A 149
PHE A 153
ILE A 156
PHE A  80
 None
 1.40A 3ko0G-5i2qA:
7.0
3ko0H-5i2qA:
7.3
3ko0I-5i2qA:
7.2
3ko0J-5i2qA:
7.3		 3ko0G-5i2qA:
25.55
3ko0H-5i2qA:
25.55
3ko0I-5i2qA:
25.55
3ko0J-5i2qA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 6 LEU A 148
SER A 149
PHE A 153
ILE A 156
 None
 0.94A 3ko0S-5i2qA:
7.2		 3ko0S-5i2qA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 8 ILE A 112
LEU A 117
MET A 121
MET A 136
 None
 0.68A 4rjdA-5i2qA:
9.7		 4rjdA-5i2qA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 7 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.87A 5b1bA-5i2qA:
undetectable
5b1bJ-5i2qA:
undetectable		 5b1bA-5i2qA:
11.61
5b1bJ-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 7 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.86A 5iy5A-5i2qA:
undetectable
5iy5J-5i2qA:
undetectable		 5iy5A-5i2qA:
11.61
5iy5J-5i2qA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 7 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.85A 5xdqA-5i2qA:
undetectable
5xdqJ-5i2qA:
undetectable		 5xdqA-5i2qA:
11.61
5xdqJ-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 8 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.88A 5xdxN-5i2qA:
undetectable
5xdxW-5i2qA:
undetectable		 5xdxN-5i2qA:
11.61
5xdxW-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 8 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.86A 5zcoA-5i2qA:
undetectable
5zcoJ-5i2qA:
undetectable		 5zcoA-5i2qA:
11.61
5zcoJ-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens) 		4 / 8 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.89A 5zcqN-5i2qA:
undetectable
5zcqW-5i2qA:
undetectable		 5zcqN-5i2qA:
11.61
5zcqW-5i2qA:
21.85