SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 212
PHE A 256
VAL A 209
 None
 0.56A 1kijB-5i2tA:
undetectable		 1kijB-5i2tA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 116
ILE A 149
ALA A  60
ILE A  73
 None
 0.78A 1n49A-5i2tA:
undetectable		 1n49A-5i2tA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  19
ILE A  71
LEU A  81
VAL A  82
LEU A  30
 None
 1.20A 1r30A-5i2tA:
undetectable		 1r30A-5i2tA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  19
ILE A  71
LEU A  81
VAL A  82
LEU A  30
 None
 1.20A 1r30B-5i2tA:
undetectable		 1r30B-5i2tA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  37
PHE A  50
TYR A  52
ASN A  64
ASP A  24
 None
 1.33A 2iyfB-5i2tA:
undetectable		 2iyfB-5i2tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 10 ASN A 259
ALA A 258
GLU A 283
ALA A 261
SER A 281
 None
 1.39A 2r2vC-5i2tA:
undetectable
2r2vF-5i2tA:
undetectable
2r2vG-5i2tA:
undetectable		 2r2vC-5i2tA:
4.11
2r2vF-5i2tA:
4.11
2r2vG-5i2tA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 10 SER A 389
HIS A 386
ASN A 349
ALA A 363
SER A 404
 None
 1.31A 2r2vC-5i2tA:
undetectable
2r2vF-5i2tA:
undetectable
2r2vG-5i2tA:
undetectable		 2r2vC-5i2tA:
4.11
2r2vF-5i2tA:
4.11
2r2vG-5i2tA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 PRO A  32
GLY A  18
TYR A  15
 None
 0.75A 2vouA-5i2tA:
undetectable		 2vouA-5i2tA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 9 ILE A 541
ARG A 524
ALA A 591
VAL A 606
 None
 0.60A 2vufA-5i2tA:
undetectable		 2vufA-5i2tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 9 ILE A 541
ARG A 524
ALA A 591
VAL A 606
 None
 0.88A 2vufB-5i2tA:
undetectable		 2vufB-5i2tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 322
GLY A 282
GLY A 278
LYS A 264
 None
 1.25A 2y4nB-5i2tA:
undetectable		 2y4nB-5i2tA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 680
VAL A 684
THR A 582
 None
 0.76A 3cyxA-5i2tA:
undetectable		 3cyxA-5i2tA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 478
PRO A 475
ASP A 517
 None
 0.81A 3hlwB-5i2tA:
undetectable		 3hlwB-5i2tA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 319
GLY A 320
GLY A 282
PHE A  22
 None
 0.97A 3ko0M-5i2tA:
undetectable
3ko0P-5i2tA:
undetectable		 3ko0M-5i2tA:
6.74
3ko0P-5i2tA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 363
THR A 348
ALA A 696
THR A 682
 None
 0.99A 3mdrB-5i2tA:
undetectable		 3mdrB-5i2tA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 390
PHE A 383
ILE A 369
ALA A 413
VAL A 361
 None
 1.01A 3me6A-5i2tA:
undetectable		 3me6A-5i2tA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 390
PHE A 383
ILE A 369
ALA A 413
VAL A 361
 None
 0.98A 3me6C-5i2tA:
undetectable		 3me6C-5i2tA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 390
PHE A 383
ILE A 369
ALA A 413
VAL A 361
 None
 0.97A 3me6D-5i2tA:
undetectable		 3me6D-5i2tA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6D_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 6 TRP A 122
PHE A  93
VAL A 102
PRO A 135
 None
 1.39A 3n6dA-5i2tA:
undetectable
3n6dB-5i2tA:
undetectable		 3n6dA-5i2tA:
18.94
3n6dB-5i2tA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 145
GLY A 144
ASP A 167
PHE A 187
ALA A 170
 None
 1.29A 3sueD-5i2tA:
undetectable		 3sueD-5i2tA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 THR A 313
ASN A 311
GLU A 315
 None
 0.76A 3v4tA-5i2tA:
undetectable
3v4tC-5i2tA:
undetectable		 3v4tA-5i2tA:
19.49
3v4tC-5i2tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 432
THR A 391
ASN A 434
 None
 0.88A 3v4tE-5i2tA:
undetectable		 3v4tE-5i2tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 337
GLN A 296
TRP A 316
 None
 1.16A 4kn2C-5i2tA:
undetectable		 4kn2C-5i2tA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 SER A 533
ALA A 531
VAL A 530
 None
 0.61A 4o2bA-5i2tA:
undetectable		 4o2bA-5i2tA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 478
PRO A 475
ASP A 517
 None
 0.85A 4pm5A-5i2tA:
undetectable		 4pm5A-5i2tA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1298_1
(GERANYLTRANSTRANSFER
ASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 172
PHE A 160
GLN A 203
ASP A 157
 None
 1.25A 4umjA-5i2tA:
undetectable		 4umjA-5i2tA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 397
ARG A 359
VAL A 360
 None
 1.05A 4x3uA-5i2tA:
undetectable
4x3uB-5i2tA:
undetectable		 4x3uA-5i2tA:
6.72
4x3uB-5i2tA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 4 PHE A 433
ASP A 451
GLY A 409
SER A 449
 None
 1.50A 4xp9C-5i2tA:
undetectable		 4xp9C-5i2tA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 351
GLY A 700
ASP A 366
ASN A 349
VAL A 393
 None
 1.28A 5d0yA-5i2tA:
undetectable		 5d0yA-5i2tA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 SER A 533
ALA A 531
VAL A 530
 None
 0.58A 5eypA-5i2tA:
undetectable		 5eypA-5i2tA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 396
HIS A 386
THR A 410
PHE A 403
THR A 391
 None
 1.26A 5hfjB-5i2tA:
undetectable		 5hfjB-5i2tA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 558
GLY A 596
GLY A 595
ALA A 695
VAL A 684
 None
 1.38A 5v3cA-5i2tA:
undetectable		 5v3cA-5i2tA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 SER A 533
ALA A 531
VAL A 530
 None
 0.54A 5xiwC-5i2tA:
undetectable		 5xiwC-5i2tA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5i2t PERIODIC TRYPTOPHAN
PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  78
HIS A  54
ARG A 619
 None
 1.05A 6dwdD-5i2tA:
undetectable		 6dwdD-5i2tA:
23.95