SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 5i2u CELLULASE
(soil
metagenome) 		3 / 3 TRP A  63
VAL A  56
TRP A  58
 None
 1.12A 1c4dC-5i2uA:
undetectable
1c4dD-5i2uA:
undetectable		 1c4dC-5i2uA:
5.51
1c4dD-5i2uA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5i2u CELLULASE
(soil
metagenome) 		5 / 12 TYR A 199
ILE A 197
ILE A 171
TYR A 155
ALA A 119
 None
 1.29A 1jtxA-5i2uA:
undetectable		 1jtxA-5i2uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 5i2u CELLULASE
(soil
metagenome) 		3 / 3 GLU A 143
ASN A 142
TRP A  43
 GOL  A 402 (-2.9A)
GOL  A 402 (-3.5A)
GOL  A 401 (-4.3A)
 1.07A 1r15C-5i2uA:
undetectable		 1r15C-5i2uA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 5i2u CELLULASE
(soil
metagenome) 		3 / 3 GLU A 143
ASN A 142
TRP A  43
 GOL  A 402 (-2.9A)
GOL  A 402 (-3.5A)
GOL  A 401 (-4.3A)
 1.13A 1r15D-5i2uA:
undetectable		 1r15D-5i2uA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5i2u CELLULASE
(soil
metagenome) 		3 / 3 GLU A 143
ASN A 142
TRP A  43
 GOL  A 402 (-2.9A)
GOL  A 402 (-3.5A)
GOL  A 401 (-4.3A)
 1.10A 1r15E-5i2uA:
undetectable		 1r15E-5i2uA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 5i2u CELLULASE
(soil
metagenome) 		3 / 3 GLU A 143
ASN A 142
TRP A  43
 GOL  A 402 (-2.9A)
GOL  A 402 (-3.5A)
GOL  A 401 (-4.3A)
 1.07A 1r15F-5i2uA:
undetectable		 1r15F-5i2uA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 5i2u CELLULASE
(soil
metagenome) 		6 / 12 ASN A 142
GLU A 143
HIS A 202
TYR A 204
GLU A 230
TRP A 264
 GOL  A 402 (-3.5A)
GOL  A 402 (-2.9A)
None
GOL  A 402 ( 4.9A)
GOL  A 402 (-2.6A)
GOL  A 402 ( 3.9A)
 0.78A 2v3dA-5i2uA:
16.7		 2v3dA-5i2uA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 5i2u CELLULASE
(soil
metagenome) 		5 / 12 ARG A  69
GLU A 139
TYR A 204
ASN A 142
HIS A 110
 None
None
GOL  A 402 ( 4.9A)
GOL  A 402 (-3.5A)
GOL  A 402 (-4.2A)
 1.47A 3bjmA-5i2uA:
undetectable		 3bjmA-5i2uA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 5i2u CELLULASE
(soil
metagenome) 		5 / 12 ARG A  69
GLU A 139
TYR A 204
ASN A 142
HIS A 110
 None
None
GOL  A 402 ( 4.9A)
GOL  A 402 (-3.5A)
GOL  A 402 (-4.2A)
 1.44A 3bjmB-5i2uA:
undetectable		 3bjmB-5i2uA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 5i2u CELLULASE
(soil
metagenome) 		5 / 11 ARG A  69
TYR A 104
VAL A  13
PRO A 134
ILE A 171
 None
 1.35A 3ganA-5i2uA:
undetectable		 3ganA-5i2uA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 5i2u CELLULASE
(soil
metagenome) 		3 / 3 HIS A 110
PHE A 122
PHE A 123
 GOL  A 402 (-4.2A)
None
None
 0.58A 3lk0D-5i2uA:
undetectable		 3lk0D-5i2uA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5i2u CELLULASE
(soil
metagenome) 		5 / 12 VAL A  94
VAL A 266
LEU A 276
GLY A 284
ALA A  55
 None
 1.08A 3rr3C-5i2uA:
undetectable		 3rr3C-5i2uA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5i2u CELLULASE
(soil
metagenome) 		5 / 12 VAL A  94
VAL A 266
LEU A 276
GLY A 284
ALA A  55
 None
 1.08A 3rr3D-5i2uA:
undetectable		 3rr3D-5i2uA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5i2u CELLULASE
(soil
metagenome) 		5 / 12 ARG A  69
GLU A 139
TYR A 204
ASN A 142
HIS A 110
 None
None
GOL  A 402 ( 4.9A)
GOL  A 402 (-3.5A)
GOL  A 402 (-4.2A)
 1.46A 3w2tA-5i2uA:
undetectable		 3w2tA-5i2uA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5i2u CELLULASE
(soil
metagenome) 		5 / 12 ARG A  69
GLU A 139
TYR A 204
ASN A 142
HIS A 110
 None
None
GOL  A 402 ( 4.9A)
GOL  A 402 (-3.5A)
GOL  A 402 (-4.2A)
 1.41A 3w2tB-5i2uA:
undetectable		 3w2tB-5i2uA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5i2u CELLULASE
(soil
metagenome) 		3 / 3 VAL A  56
TRP A  58
TRP A  63
 None
 1.43A 3zq8A-5i2uA:
undetectable
3zq8B-5i2uA:
undetectable		 3zq8A-5i2uA:
5.51
3zq8B-5i2uA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5i2u CELLULASE
(soil
metagenome) 		4 / 6 HIS A 202
GLU A 230
ASP A 108
SER A  40
 None
GOL  A 402 (-2.6A)
None
None
 1.04A 4apjA-5i2uA:
undetectable
4apjP-5i2uA:
undetectable		 4apjA-5i2uA:
18.99
4apjP-5i2uA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 5i2u CELLULASE
(soil
metagenome) 		3 / 3 GLU A 271
GLY A 238
SER A 265
 GOL  A 401 (-2.7A)
GOL  A 402 ( 4.4A)
None
 0.69A 4b53B-5i2uA:
undetectable		 4b53B-5i2uA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5i2u CELLULASE
(soil
metagenome) 		4 / 7 TRP A 179
TRP A 141
PHE A 147
GLU A 143
 None
None
None
GOL  A 402 (-2.9A)
 1.47A 4cwyA-5i2uA:
0.9
4cwyB-5i2uA:
0.8		 4cwyA-5i2uA:
21.73
4cwyB-5i2uA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5i2u CELLULASE
(soil
metagenome) 		4 / 8 TRP A 179
TRP A 141
PHE A 147
GLU A 143
 None
None
None
GOL  A 402 (-2.9A)
 1.47A 4uchA-5i2uA:
undetectable
4uchB-5i2uA:
undetectable		 4uchA-5i2uA:
19.50
4uchB-5i2uA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5i2u CELLULASE
(soil
metagenome) 		4 / 7 TRP A 179
TRP A 141
PHE A 147
GLU A 143
 None
None
None
GOL  A 402 (-2.9A)
 1.49A 4v3wA-5i2uA:
1.0
4v3wB-5i2uA:
undetectable		 4v3wA-5i2uA:
19.72
4v3wB-5i2uA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5i2u CELLULASE
(soil
metagenome) 		4 / 4 LEU A 173
ARG A 164
ILE A 197
ILE A 160
 None
 1.04A 5dzk2-5i2uA:
undetectable
5dzkM-5i2uA:
1.8
5dzkN-5i2uA:
undetectable		 5dzk2-5i2uA:
0.67
5dzkM-5i2uA:
21.56
5dzkN-5i2uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5i2u CELLULASE
(soil
metagenome) 		4 / 4 ILE A 197
ILE A 160
ARG A 164
LEU A 173
 None
 1.00A 5dzkh-5i2uA:
1.8
5dzkn-5i2uA:
undetectable
5dzkv-5i2uA:
undetectable		 5dzkh-5i2uA:
21.56
5dzkn-5i2uA:
21.56
5dzkv-5i2uA:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5i2u CELLULASE
(soil
metagenome) 		3 / 3 MET A 201
GLN A 181
ARG A 215
 None
 1.06A 5m35B-5i2uA:
undetectable		 5m35B-5i2uA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5i2u CELLULASE
(soil
metagenome) 		3 / 3 MET A 201
GLN A 181
ARG A 215
 None
 1.04A 5m36A-5i2uA:
undetectable		 5m36A-5i2uA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5i2u CELLULASE
(soil
metagenome) 		4 / 8 PHE A 123
THR A 200
ILE A 140
GLY A 175
 None
 0.98A 5nzxA-5i2uA:
undetectable		 5nzxA-5i2uA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5i2u CELLULASE
(soil
metagenome) 		4 / 7 PHE A 123
THR A 200
ILE A 140
GLY A 175
 None
 0.93A 5nzyA-5i2uA:
2.2		 5nzyA-5i2uA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5i2u CELLULASE
(soil
metagenome) 		4 / 7 TRP A 179
TRP A 141
PHE A 147
GLU A 143
 None
None
None
GOL  A 402 (-2.9A)
 1.48A 5vv9A-5i2uA:
undetectable
5vv9B-5i2uA:
undetectable		 5vv9A-5i2uA:
21.73
5vv9B-5i2uA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5i2u CELLULASE
(soil
metagenome) 		4 / 7 TRP A 179
TRP A 141
PHE A 147
GLU A 143
 None
None
None
GOL  A 402 (-2.9A)
 1.45A 5vvdA-5i2uA:
undetectable
5vvdB-5i2uA:
undetectable		 5vvdA-5i2uA:
21.60
5vvdB-5i2uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5i2u CELLULASE
(soil
metagenome) 		4 / 7 TRP A 179
TRP A 141
PHE A 147
GLU A 143
 None
None
None
GOL  A 402 (-2.9A)
 1.49A 6auuA-5i2uA:
0.1
6auuB-5i2uA:
undetectable		 6auuA-5i2uA:
12.16
6auuB-5i2uA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5i2u CELLULASE
(soil
metagenome) 		4 / 7 TRP A 179
TRP A 141
PHE A 147
GLU A 143
 None
None
None
GOL  A 402 (-2.9A)
 1.50A 6av6A-5i2uA:
undetectable
6av6B-5i2uA:
undetectable		 6av6A-5i2uA:
11.87
6av6B-5i2uA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5i2u CELLULASE
(soil
metagenome) 		5 / 12 ARG A  69
GLU A 139
TYR A 204
ASN A 142
HIS A 110
 None
None
GOL  A 402 ( 4.9A)
GOL  A 402 (-3.5A)
GOL  A 402 (-4.2A)
 1.43A 6b1eB-5i2uA:
undetectable		 6b1eB-5i2uA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5i2u CELLULASE
(soil
metagenome) 		4 / 7 TRP A 179
TRP A 141
PHE A 147
GLU A 143
 None
None
None
GOL  A 402 (-2.9A)
 1.49A 6cieA-5i2uA:
undetectable
6cieB-5i2uA:
undetectable		 6cieA-5i2uA:
11.87
6cieB-5i2uA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5i2u CELLULASE
(soil
metagenome) 		3 / 3 MET A 201
GLN A 181
ARG A 215
 None
 1.02A 6fn9A-5i2uA:
undetectable		 6fn9A-5i2uA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5i2u CELLULASE
(soil
metagenome) 		3 / 3 MET A 201
GLN A 181
ARG A 215
 None
 1.06A 6fnaB-5i2uA:
undetectable		 6fnaB-5i2uA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5i2u CELLULASE
(soil
metagenome) 		3 / 3 MET A 201
GLN A 181
ARG A 215
 None
 1.02A 6fnbA-5i2uA:
undetectable		 6fnbA-5i2uA:
23.58